Creatine supplement side effects under the microscope

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ○ Subjects must be healthy males or females, aged 18 to 60 inclusive at the time of screening. * Subjects must be able to understand the study, agree to the requirements and restrictions, and be willing to give voluntary consent to participate in the study. * Subjects are willing to have up to two (2) blood collections, one at Visit 2 and Visit 3. * Subjects are willing to provide a urine sample that is collected over 24 hours. This entails collecting all urine in a 24-hour period in a container. * Subject is willing to fast for 12 hours before the Baseline visit (second visit). Water is permitted. * Subject is willing to have waist measurements taken with calipers and willing to wear clothing that allows easy access to their waist. * Female subjects of childbearing potential must agree to one of the following methods of birth control through the duration of the study. Acceptable methods include: abstinence, same-sex partner, double barrier (condom, diaphragm, or cervical cap with spermicidal foam, gel, or cream); intra-uterine device (IUD) with or without hormones in place or hormonal contraception (oral, injectable, implantable, transdermal, or vaginal) used consecutively for at least 3 month prior to screening visit; vasectomized partner or bilateral insertion of Essure® implants (or analogous) for at least 6 months prior to the screening visit; to be considered a female of non- childbearing potential, subject must have had a bilateral tubal ligation, hysterectomy or bilateral oophorectomy; or postmenopausal status with amenorrhea (no menstruation) for at least 1 year prior to the screening visit. * Subject is willing to comply with the study restrictions. * Subjects is willing to maintain their current exercise regimen and their current diet while on the study. Exclusion Criteria: * ○ Subjects who are participating in another Clinical Trial. * Subjects who faint during blood collection, or who have a phobia of needles, or a phobia of blood. * Subjects who are weightlifters. * Females who are pregnant or lactating (verbal confirmation only). * Subject who has taken any creatine supplements in the last 30 days. * Subjects with history of cancer (except localized skin cancer without metastases) within 5 years prior to the screening visit. * Subject has diabetes (insulin dependent or not) or any immune deficiency disease such as HIV/AIDS, etc. * Subject has any medical condition whether treating with mediation or not including hypertension (high blood pressure), hepatitis, any kidney disease or disorders, or musculoskeletal disorders. Note: if there are any significantly abnormal results for the BUN/creatinine screening labs the subject will be dropped. * Subject is taking a medication that would preclude participation in the study per the Principal Investigator. * Subjects with recent or current medical condition that may significantly impact the subject or the validity of the study results in the opinion of the Investigator. * Subjects who have a known or suspected allergy or sensitivity to creatine. * Chronic use of NSAIDs (e.g., Ibuprofen, Advil), or use of NSAIDs at one-week prior to each study visit.