Could a simple creatine pill replace strict diets for a rare metabolic disorder?
NCT ID NCT06495567
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests whether taking creatine supplements for a week can lower the production of homocysteine, a toxic amino acid, in healthy adult men. Homocystinuria is a rare inherited disorder where the body cannot break down homocysteine, often requiring a difficult low-protein diet. Researchers will measure changes in breath, urine, and blood to see if creatine might one day offer a more palatable treatment option for patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- creatine (dietary supplement)
- What this could lead to
- If it works, this could point toward a simpler, tastier treatment for homocystinuria that might replace strict low-protein diets.
- What could go wrong
- This is a very small, early proof-of-concept study in just 9 healthy men, not people with the disease. It only tests short-term effects, so results may not apply to patients or lead to a real treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
BC Children's Hospital Research Institute, University of British Columbia
Vancouver, British Columbia, V5Z4H4, Canada
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Other studies related to the condition(s) this trial covers.