Could a simple creatine pill replace strict diets for a rare metabolic disorder?
NCT ID NCT06495567
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tests whether taking creatine supplements for a week can lower the production of homocysteine, a toxic amino acid, in healthy adult men. Homocystinuria is a rare inherited disorder where the body cannot break down homocysteine, often requiring a difficult low-protein diet. Researchers will measure changes in breath, urine, and blood to see if creatine might one day offer a more palatable treatment option for patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
creatine (dietary supplement)
What this could lead to
If it works, this could point toward a simpler, tastier treatment for homocystinuria that might replace strict low-protein diets.
What could go wrong
This is a very small, early proof-of-concept study in just 9 healthy men, not people with the disease. It only tests short-term effects, so results may not apply to patients or lead to a real treatment.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BC Children's Hospital Research Institute, University of British Columbia
Vancouver, British Columbia, V5Z4H4, Canada