Creatine supplement may offer new hope for rare metabolic disorder

This study tests whether creatine supplements can lower harmful homocysteine levels in healthy men, as a first step toward a new treatment for homocystinuria. Homocystinuria is a rare genetic disorder where the body cannot break down homocysteine, leading to heart, brain, and bone damage. Current treatment requires a strict low-protein diet, which is hard to follow. Nine healthy adult men will take creatine for a week and provide breath, urine, and blood samples to measure changes in homocysteine production.