New COVID booster shows promise in trial
NCT ID NCT06181292
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a new booster vaccine called PHH-1V81, designed to target recent COVID-19 variants. About 900 adults who had already received mRNA vaccines got either the new booster or an existing one. Researchers checked for side effects and measured immune responses to see if the new booster is safe and works as well as current options.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PHH-1V81 (adapted protein booster vaccine against SARS-CoV-2)
What this could lead to
If successful, this could provide a safe and effective booster option that protects against newer COVID-19 variants.
What could go wrong
This is a mid-stage trial with 913 participants, so results may not apply to everyone. The vaccine may not work as well as existing boosters or could cause side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CAP Centelles
Centelles, Barcelona, 08540, Spain
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Hospital Clínico Universitario de Valencia
Valencia, Valencia, 46010, Spain
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Hospital Germans Trias i Pujol
Badalona, Barcelona, 08916, Spain
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Hospital HM Delfos
Barcelona, Barcelona, 08023, Spain
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Hospital HM Puerta del Sur
Móstoles, Madrid, 28938, Spain
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Hospital HM Sanchinarro
Madrid, Madrid, 28050, Spain
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Hospital Josep Trueta
Girona, Girona, 17001, Spain
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Hospital Quironsalud Madrid
Madrid, Madrid, 28223, Spain
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Hospital Regional de Málaga
Málaga, Málaga, 29010, Spain
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Hospital Universitario de Cruces
Barakaldo, Vizcaya, 48903, Spain