New COVID booster shows promise in trial

NCT ID NCT06181292

Completed ⭐️ VACCINE ⭐️ Sponsor: Hipra Scientific, S.L.U Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new booster vaccine called PHH-1V81, designed to target recent COVID-19 variants. About 900 adults who had already received mRNA vaccines got either the new booster or an existing one. Researchers checked for side effects and measured immune responses to see if the new booster is safe and works as well as current options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PHH-1V81 (adapted protein booster vaccine against SARS-CoV-2)
What this could lead to: If successful, this could provide a safe and effective booster option that protects against newer COVID-19 variants.
What could go wrong: This is a mid-stage trial with 913 participants, so results may not apply to everyone. The vaccine may not work as well as existing boosters or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

COVID-19 prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARS-COV2 INFECTION

Contacts and locations

Locations

CAP Centelles

Centelles, Barcelona, 08540, Spain
Hospital Clínico Universitario de Valencia

Valencia, Valencia, 46010, Spain
Hospital Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
Hospital HM Delfos

Barcelona, Barcelona, 08023, Spain
Hospital HM Puerta del Sur

Móstoles, Madrid, 28938, Spain
Hospital HM Sanchinarro

Madrid, Madrid, 28050, Spain
Hospital Josep Trueta

Girona, Girona, 17001, Spain
Hospital Quironsalud Madrid

Madrid, Madrid, 28223, Spain
Hospital Regional de Málaga

Málaga, Málaga, 29010, Spain
Hospital Universitario de Cruces

Barakaldo, Vizcaya, 48903, Spain

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