New drug combo could replace chemo for lymphoma patients

NCT ID NCT03474744

First seen May 13, 2026 · Last updated May 16, 2026 · Updated 1 time

Summary

This study tests a chemotherapy-free combination of two drugs, Copanlisib and Rituximab, in 36 people with marginal zone lymphoma (MZL) who need treatment but cannot have or have failed local therapy. The goal is to see if this combo works as well as standard chemo but with fewer side effects, especially for older patients. The main measure is complete response rate 12 months after starting treatment.

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Contacts and locations

Locations

  • Elblandkliniken Stiftung & Co. KG, Innere Medizin II

    Riesa, 01589, Germany

  • Gemeinschaftspraxis, Fachärzte für Innere Medizin

    Mannheim, 68161, Germany

  • Johanniter GmbH, Johanniter-Krankenhaus

    Bonn, 53113, Germany

  • Kath. Karl-Leisner-Klinikum gGmbH, Betriebsstätte Wilhelm-Anton-Hospital

    Goch, 47574, Germany

  • Kliniken Ostalb Stauferklinikum Schwäbisch Gmünd, Zentrum für Innere Medizin

    Mutlangen, 73557, Germany

  • Klinikum der Universität München, Medizinische Klinik und Poliklinik III

    München, 83177, Germany

  • MVZ Goslar, MVZ Onkologische Kooperation Harz

    Goslar, 38642, Germany

  • Med. Uni Wien AKH, Klinische Abteilung für Onkologie, Innere Medizin I

    Vienna, 1190, Austria

  • Rotes Kreuz Krankenhaus, Klinik für Interdisziplinäre Onkologie

    Kassel, 34121, Germany

  • Sana Klinikum Offenbach GmbH

    Offenbach, 63069, Germany

  • St. Josef-Hospital, Medizinische Klinik I

    Bochum, 44791, Germany

  • University Hospital Ulm

    Ulm, 89081, Germany

  • Universitätsklinik PIUS Hospital, Innere Medizin

    Oldenburg, 26121, Germany

  • Universitätsklinikum Halle, Klinik und Poliklinik für Innere Medizin

    Halle, 06120, Germany

  • Universitätsmedizin Mannheim, III. Medizinische Klinik

    Mannheim, 68167, Germany

  • Universitätsmedizin Rostock

    Rostock, 18051, Germany

  • ÜBAG MVZ Dr. Vehling-Kaiser GmbH

    Landshut, 84036, Germany

  • ÜBAG MVZ Dr. Vehling-Kaiser GmbH Dingolfing

    Dingolfing, 84113, Germany

Conditions

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