Major CLL trial tests three drug combos to find best control strategy

NCT ID NCT04608318

First seen May 02, 2026 · Last updated May 02, 2026

Summary

This study compares three treatment approaches for people with previously untreated chronic lymphocytic leukemia (CLL): one drug taken continuously (ibrutinib), two drugs given for a fixed time (venetoclax plus obinutuzumab), and a combination of two drugs for a fixed time (ibrutinib plus venetoclax). The goal is to see which approach best delays the cancer from growing or coming back. About 900 adults with CLL who need treatment are taking part.

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Contacts and locations

Locations

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, 20162, Italy

  • Aalborg Universitetshospital

    Aalborg, 9000, Denmark

  • Aarhus Universitetshospital

    Aarhus, 8200, Denmark

  • Akershus University Hospital

    Lørenskog, 1478, Norway

  • Albert Schweitzer Ziekenhuis

    Dordrecht, 3318AT, Netherlands

  • Algemeen Ziekenhuis Delta

    Roeselare, 8800, Belgium

  • Algemeen Ziekenhuis St. Jan

    Bruges, 8000, Belgium

  • Alrijne Ziekenhuis

    Leiderdorp, 2353GA, Netherlands

  • Amphia Ziekenhuis

    Breda, 4818CK, Netherlands

  • Amsterdam Universitair Medische Centra

    Amsterdam, 1105AZ, Netherlands

  • Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino

    Torino, 10126, Italy

  • Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele

    Catania, 9513, Italy

  • Azienda Ospedaliero Universitaria di Ferrara

    Ferrara, 44124, Italy

  • Barmherzigen Brüder Krankenhaus

    Regensburg, 93049, Germany

  • Beaumont Hospital

    Dublin, Dublin 9, Ireland

  • Bnai-Zion Medical Center

    Haifa, 31048, Israel

  • Brüderkrankenhaus St. Josef Paderborn

    Paderborn, 33098, Germany

  • Canisius-Wilhelmina Ziekenhuis

    Nijmegen, 6532SZ, Netherlands

  • Centrum für Hämatologie und Onkologie Bethanien

    Frankfurt, 60389, Germany

  • Chaim Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Charite Universitaetsmedizin - Campus Benjamin Franklin

    Berlin, 12203, Germany

  • Charite Universitätsmedizin - Campus Virchow Klinikum

    Berlin, 13353, Germany

  • Cork University Hospital

    Cork, T12DC4A, Ireland

  • Diakonessenhuis

    Utrecht, 3582 KE, Netherlands

  • Ev. Diakoniekrankenhaus

    Bremen, 28239, Germany

  • Evangelische Krankenhaus Hamm

    Hamm, 59063, Germany

  • Falu Lasarett

    Falun, 79182, Sweden

  • Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Franciscus Vlietland

    Schiedam, 3118JH, Netherlands

  • Galilee Medical Center

    Nahariya, 22100, Israel

  • Gemeinschaftspraxis Haematologie und Onkologie

    Magdeburg, 39104, Germany

  • Gemeinschaftspraxis Hämatologie Onkologie

    Dresden, 1307, Germany

  • Gemeinschaftspraxis für Hämatologie & Onkologie

    Dortmund, 44263, Germany

  • Gemeinschaftspraxis für Hämatologie und Onkologie

    Münster, 48153, Germany

  • Gemeinschaftspraxis für Hämatologie und Onkologie

    Ravensburg, 88212, Germany

  • Gmelli University Hospital

    Roma, 168, Italy

  • H.O.T Onkologie Praxis Landshut

    Landshut, 84036, Germany

  • HFR Fribourg Hôpital cantonal

    Fribourg, 1708, Switzerland

  • Hadassah Medical Center Ein Kerem University Hospital

    Jerusalem, 91120, Israel

  • Hallands Sjukhus

    Varberg, 43281, Sweden

  • Hallands Sjukhus Halmstad

    Halmstad, 30185, Sweden

  • Hanusch Krankenhaus

    Vienna, 1140, Austria

  • Haukeland University Hospital

    Bergen, 5021, Norway

  • Helios Klinikum Berlin Buch

    Berlin, 13125, Germany

  • Helsinki University Hospital

    Helsinki, 29, Finland

  • Hospital Clinic de Barcelona

    Barcelona, 8036, Spain

  • Hospital Clinico Universitario Lozano Blesa

    Zaragoza, 50009, Spain

  • Hospital Clinico Universitario Valencia

    Valencia, 46010, Spain

  • Hospital Clinico Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hospital Costa del Sol

    Málaga, 29603, Spain

  • Hospital Duran i Reynals

    Barcelona, 8908, Spain

  • Hospital Germans Trias i Pujol

    Badalona, 8916, Spain

  • Hospital Marques de Valdecilla

    Santander, 39008, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Central de Asturias

    Oviedo, 33011, Spain

  • Hospital Universitario Infanta Leonor

    Madrid, 28031, Spain

  • Hospital Universitario La Princesa

    Madrid, 28006, Spain

  • Hospital Universitario Virgen de Valme

    Seville, 41014, Spain

  • Hämatologisch Onkologische Schwerpunktpraxis

    Würzburg, 97080, Germany

  • Hôpitaux Universitaires Genève

    Geneva, 1211, Switzerland

  • IRCCS Ospedale San Raffaele

    Milan, 202132, Italy

  • ISP Erlangen Onkologische Schwerpunktpraxis

    Erlangen, 91052, Germany

  • Inselspital Bern

    Bern, 3010, Switzerland

  • Isala Zwolle

    Zwolle, 8025AB, Netherlands

  • Jeroen Bosch Ziekenhuis

    's-Hertogenbosch, 5223GZ, Netherlands

  • Kantonsspital Aarau

    Aarau, 5001, Switzerland

  • Kantonsspital Baden

    Baden, 5404, Switzerland

  • Kantonsspital Baselland

    Liestal, 4410, Switzerland

  • Kantonsspital Graubünden

    Chur, 7000, Switzerland

  • Kantonsspital Olten

    Olten, 4600, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007, Switzerland

  • Kantonsspital Winterthur

    Winterthur, 8401, Switzerland

  • Kaplan Medical Center

    Rehovot, 7610001, Israel

  • Karolinska University Hospital Solna

    Stockholm, 17176, Sweden

  • Kliniken Maria Hilf

    Mönchengladbach, 41063, Germany

  • Klinikum Lippe Lemgo

    Lemgo, 32657, Germany

  • Klinikum Oldenburg

    Oldenburg, 26133, Germany

  • Klinikum der Universitaet München - Grosshadern Campus

    München, 81377, Germany

  • Klinikum rechts der Isar - Technische Universitaet Muenchen

    München, 81675, Germany

  • LKH-Universtitätsklinikum Graz

    Graz, 8036, Austria

  • Landeskrankenhaus - Universitätskliniken Innsbruck

    Innsbruck, 6020, Austria

  • Lillebaelt Vejle Sygehus

    Vejle, 7100, Denmark

  • Luzerner Kantonsspital

    Lucerne, 6000, Switzerland

  • Lübecker Onkologische Schwerpunktpraxis

    Lübeck, 23562, Germany

  • MVZ Hämatologie Onkologie Koblenz

    Koblenz, 56727, Germany

  • MVZ Onkologische Kooperation Harz

    Goslar, 38642, Germany

  • MVZ Weiden GmbH

    Weiden, 92637, Germany

  • Maasstad Ziekenhuis

    Rotterdam, 3079DZ, Netherlands

  • Mannheimer Onkologie Praxis

    Mannheim, 68161, Germany

  • Marien Hospital Herne

    Herne, 44625, Germany

  • Marienhospital Stuttgart

    Stuttgart, 70199, Germany

  • Martini Ziekenhuis

    Groningen, 9728NT, Netherlands

  • Mater Misericordiae University Hospital

    Dublin, Dublin 7, Ireland

  • Medisch Centrum Leeuwarden

    Leeuwarden, 8934AD, Netherlands

  • Medizinische Universität Wien

    Vienna, 1090, Austria

  • Meir Medical Center

    Kfar Saba, 4428164, Israel

  • München Klinik Schwabing

    München, 80804, Germany

  • Nordwest Ziekenhuisgroep, Locatie Alkmaar

    Alkmaar, 1815JD, Netherlands

  • OLVG Amsterdam

    Amsterdam, 1091AC, Netherlands

  • Odense Universitetshospital

    Odense, 5000, Denmark

  • OncoResearch Lerchenfeld

    Hamburg, 22081, Germany

  • OnkoSaar Praxis für Hämatologie und Onkologie

    Saarbrücken, 66113, Germany

  • Onkologische Schwerpunktpraxis

    Esslingen am Neckar, 73728, Germany

  • Onkologische Schwerpunktpraxis Heidelberg

    Heidelberg, 69115, Germany

  • Onkologische Schwerpunktpraxis Kurfürstendamm

    Berlin, 10707, Germany

  • Onkologisches Ambulanzzentrum - MediProjekt

    Hanover, 30171, Germany

  • Onkopraxis Probstheida

    Leipzig, 4289, Germany

  • Oslo University Hospital

    Oslo, 372, Norway

  • Ospedale Regionale Bellinzona e Valli

    Bellinzona, 6500, Switzerland

  • Ospedale S. Maria della Misericordia

    Perugia, 6123, Italy

  • Ospedale dell'Angelo

    Mestre, 30174, Italy

  • Praxis für Haematologie und Onkologie

    Koblenz, 56068, Germany

  • Praxis für Innere Medizin - Hämatologie und Onkologie

    Marburg, 35037, Germany

  • Rabin Medical Center Beilinson Hospital

    Petah Tikva, 4941492, Israel

  • Regionshospitalet Holstebro

    Holstebro, 7500, Denmark

  • Reinier de Graaf Ziekenhuis

    Delft, 2625AD, Netherlands

  • Residencia Sanitaria La Fe - Valencia

    Valencia, 46026, Spain

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Rijnstate, Locatie Arnhem

    Arnhem, 6815AD, Netherlands

  • Robert-Bosch-Krankenhaus

    Stuttgart, 70376, Germany

  • Sahlgrenska University Hospital

    Gothenburg, 41346, Sweden

  • Sana Krankenhaus Benrath

    Düsseldorf, 40593, Germany

  • Schwerpunktpraxis für Hämatologie & Onkologie - OncoPro GbR

    Regensburg, 93053, Germany

  • Shamir Medical Center Assaf Harofeh

    Be’er Ya‘aqov, 70300, Israel

  • Skåne University Hospital

    Lund, 22185, Sweden

  • Slingeland ziekenhuis

    Doetinchem, 7009BL, Netherlands

  • Soedra Aelvsborgs Sjukhus

    Borås, 50182, Sweden

  • Soroka University Medical Center

    Beersheba, 84101, Israel

  • Spital Thun

    Thun, 3600, Switzerland

  • Spital Thurgau AG - Kantonsspital Münsterlingen

    Münsterlingen, 8596, Switzerland

  • Spitalzentrum Oberwallis

    Brig, 3900, Switzerland

  • St Vincents University Hospital

    Dublin, Dublin 4, Ireland

  • St Vincenz Krankenhaus

    Limburg, 65549, Germany

  • St. Antonius Ziekenhuis

    Nieuwegein, 3435CM, Netherlands

  • St. Georg Klinikum Eisenach

    Eisenach, 99817, Germany

  • St. James's Hospital

    Dublin, Dublin 8, Ireland

  • St. Olavs Hospital Trondheim University Hospital

    Trondheim, 7030, Norway

  • Stadtspital Triemli

    Zurich, 8063, Switzerland

  • Stauferklinikum Schwäbisch Gmünd

    Mutlangen, 73557, Germany

  • Sunderby Hospital

    Luleå, 97180, Sweden

  • Sydvestjysk Sygehus Esbjerg

    Esbjerg, 6700, Denmark

  • Tampere University Hospital

    Tampere, 33520, Finland

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906, Israel

  • Turku University Hospital

    Turku, 20521, Finland

  • Umberto I - Policlinico di Roma - Sapienza Università

    Roma, 161, Italy

  • Umeå University Hospital

    Umeå, 90185, Sweden

  • Uniklinikum Gießen und Marburg

    Giessen, 35392, Germany

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel

    Kiel, 24105, Germany

  • Universitair Ziekenhuis Leuven

    Leuven, 3000, Belgium

  • Universitetssjukhuset Linköping

    Linköping, 58185, Sweden

  • University Hospital Galway

    Galway, H91 YR71, Ireland

  • University Hospital Limerick

    Limerick, V94 F858, Ireland

  • University Hospital Waterford

    Waterford, X91 ER8E, Ireland

  • Universitätsklinik Carl Gustav Carus

    Dresden, 1307, Germany

  • Universitätsklinik Köln

    Cologne, 50924, Germany

  • Universitätsklinik Rostock

    Rostock, 18057, Germany

  • Universitätsklinik Tübingen

    Tübingen, 72076, Germany

  • Universitätskliniken des Saarlandes

    Homburg, 66424, Germany

  • Universitätsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Jena

    Jena, 7747, Germany

  • Universitätsklinikum Leipzig

    Leipzig, 4103, Germany

  • Universitätsklinikum Magdeburg

    Magdeburg, 39120, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Universitätsspital Basel

    Basel, 4031, Switzerland

  • Universitätsspital Zuerich

    Zurich, 8091, Switzerland

  • Uppsala University Hospital

    Uppsala, 75185, Sweden

  • Vall d'Hebron University Hospital

    Barcelona, 8035, Spain

  • VieCuri Medish Centrum

    Venlo, 5912BL, Netherlands

  • Westpfalz-Klinikum GmbH

    Kaiserslautern, 67655, Germany

  • Wiener Gesundheitsverbund Klinik Ottakring

    Vienna, 1160, Austria

  • Zealand University Hospital

    Roskilde, 4000, Denmark

  • Zentrum für abulante Hämatologie und Onkologie

    Siegburg, 53721, Germany

  • Ziekenhuis Gelderse Vallei

    Ede, 6716RP, Netherlands

  • Ziekenhuis Rivierenland Tiel

    Tiel, 4002WP, Netherlands

  • Ziekenhuis St Jansdal

    Harderwijk, 3844DG, Netherlands

  • Örebro University Hospital

    Örebro, 70185, Sweden

Conditions

Explore the condition pages connected to this study.