New chemo cocktail tested to prevent colon cancer return
NCT ID NCT02967289
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a stronger chemotherapy combination (mFOLFIRINOX) works better than the standard one (mFOLFOX) for people with high-risk stage III colon cancer after surgery. About 792 patients took part across multiple countries. The goal was to see if the stronger combo could keep the cancer from coming back longer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mFOLFIRINOX (combination of 5-fluorouracil, folinic acid, irinotecan, and oxaliplatin) versus mFOLFOX (oxaliplatin, folinic acid, and 5-fluorouracil)
- What this could lead to
- If successful, this could establish a more effective chemotherapy option to reduce the risk of cancer returning after surgery for high-risk stage III colon cancer.
- What could go wrong
- This is a completed phase III trial, so results are available but may show no significant benefit or increased side effects with the more intensive regimen. The findings apply only to a specific high-risk group.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
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CHD de Vendée
La Roche-sur-Yon, France
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CHP Saint Grégoire
Saint-Grégoire, France
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Centre Hospitalier Annecy Genevois
Pringy, France
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Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
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Ch Emile Roux
Le Puy-en-Velay, France
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Clinique de la Côte d'Emeraude
St-Malo, France
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Hopital Charles LeMoyne
Greenfield Park, Quebec, Canada
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Hospices civils de Lyon - Hôpital Edouard Herriot
Lyon, France
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Hôpital Européen Georges Pompidou
Paris, France
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Hôpital Saint Antoine
Paris, France
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Hôpital privé Jean Mermoz
Lyon, France
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Icm Val D'Aurelle
Montpellier, France
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Institut Jean Godinot
Reims, France
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Institut de Cancérologie de l'Ouest -site Paul Papin
Angers, France
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Institut de Cancérologie de l'Ouest -site René Gauducheau
Nantes, France
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The PEI Cancer Treatment Centre Queen Elizabeth Hospital
Charlottetown, Prince Edward Island, Canada
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