New combo therapy shows promise for Tough-to-Treat cancers

NCT ID NCT05077709

First seen Apr 14, 2026 · Last updated Apr 28, 2026 · Updated 3 times

Summary

This study tested a new combination of two immunotherapy drugs (IO102-IO103 and pembrolizumab) as a first treatment for people with advanced lung, head/neck, or bladder cancer that had spread. The goal was to see if the combo could shrink tumors and delay cancer growth. 63 patients took part. The approach aims to boost the immune system to fight cancer, but ongoing management is still needed.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Guys and St Thomas Hospital

    London, United Kingdom

  • Hospital Clínico Lozano Blesa

    Zaragoza, Zaragoza, 50009, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, Valencia, Spain

  • Hospital Universitari de Girona Doctor Josep Trueta

    Girona, 17007, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Fundación Jiménez Díaz

    Madrid, 28040, Spain

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen Macarena

    Seville, Sevilla, 41009, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Vall d'Hebron

    Barcelona, 08035, Spain

  • Institut Català d'Oncologia (ICO) Badalona (Catalan Institute of Oncology)

    Barcelona, 08916, Spain

  • Mid Florida Hematology and Oncology Center

    Orange City, Florida, 32763, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • UC Davis Cancer Center

    Sacramento, California, 95817, United States

  • University of California San Diego

    San Diego, California, 92093, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Toledo Medical Center

    Toledo, Ohio, 43614, United States

  • Velindre Cancer Center

    Cardiff, CF14 2TL, United Kingdom

  • Virginia Cancer Specialists

    Fairfax, Virginia, 22031, United States

Conditions

Explore the condition pages connected to this study.