New combo therapy aims to shrink Hard-to-Treat cancers

NCT ID NCT05155033

First seen Jan 27, 2026 · Last updated Apr 25, 2026 · Updated 8 times

Summary

This study tests whether combining two drugs—pembrolizumab (an immunotherapy) and aldesleukin (a protein that boosts immune cells)—can shrink tumors in people with advanced melanoma or kidney cancer that has not responded to prior treatments. About 78 adults will receive the drugs through an IV during two hospital stays, followed by additional pembrolizumab alone. The goal is to see if the combination leads to tumor shrinkage and how long that effect lasts.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.