New drug COM503 enters first human trial for advanced cancers

NCT ID NCT06759649

Recruiting now Disease control Sponsor: Compugen Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This early-stage trial tests a new drug called COM503, alone or with another drug zimberelimab, in 200 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the right dose. It is a first-in-human study, so effectiveness is not yet known.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: COM503 (a drug given by IV) and zimberelimab (another drug given by IV)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced solid tumors who have run out of standard therapies.
What could go wrong: This is a very early Phase 1 trial, so the main goal is safety, not effectiveness. It may not work, and side effects are unknown. Only 200 people are enrolled, so results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER, MALIGNANT TUMORS NEOPLASM

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 0221502215, United States
Hadassah University Medical Center- Ein Kerem
RECRUITING

Jerusalem, Israel, 9112001, Israel
NEXT Oncology San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
NEXT Oncology Virginia
RECRUITING

Fairfax, Virginia, 22031, United States
Rabin Medical Center
RECRUITING

Petah Tikva, Israel, 4941492, Israel
Rambam Health Care Campus
RECRUITING

Haifa, Israel, 3109601, Israel
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
START- San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
The Chaim Sheba Medical Center
RECRUITING

Ramat Gan, Israel, 5465601, Israel
The West Clinic, PLCC dba West Cancer Center
RECRUITING

Germantown, Tennessee, 38138, United States
Yale- New Haven Hospital- Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

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