New drug shows promise for rare blood disorder

NCT ID NCT05096403

Completed Disease control Sponsor: Swedish Orphan Biovitrum Source: ClinicalTrials.gov ↗

Summary

This study tested whether a drug called pegcetacoplan could help people with cold agglutinin disease, a rare condition where the immune system attacks red blood cells. Twenty-four adults with the disease received either the drug or a placebo via twice-weekly injections at home for 24 weeks. The main goals were to see if the drug could raise hemoglobin levels and help patients avoid needing blood transfusions.

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Contacts and locations

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Locations

"LTD Medinvest Institute of Hematology and Transfusiology "

Tbilisi, Georgia
"FOND IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Italy
A.O.R.N. S.G. Moscati di Avellino

Avellino, 83100, Italy
AOU Maggiore della Carità SCDU Ematologia

Novara, Italy
ASST degli Spedali Civili di Brescia_Presidio Ospedaliero di Brescia_U.O. Ematologia

Brescia, 25123, Italy
Aichi Medical University Hospital

Nagakute, 480-1195, Japan
Algemeen Ziekenhuis Klina

Brasschaat, 2930, Belgium
Amsterdam UMC

Amsterdam, Netherlands
Azienda Ospedaliera Ospedali Riuniti ""Villa Sofia-Cervello

Palermo, 90146, Italy
CHU de Liège

Liège, 4000, Belgium
Cancer Clinical Trials Unit, Haematology -University College London -

London, United Kingdom
Churchill Hospital

Oxford, United Kingdom
East Carolina University Division of Hematology/ Oncology

Greenville, North Carolina, 27858, United States
Fukushima Medical University Hospital

Fukushima, Japan
Grande Ospedale Metropolitano ""Bianchi - Melacrino - Morellii

Reggio Calabria, 89133, Italy
Haukeland University Hospital

Bergen, Norway
Helsinki University Hospital - Comprehensive Cancer Center

Helsinki, Finland
Hospital Clinic de Barcelona

Barcelona, Spain
Hospital Clínico Universitario de Salamanca

Madrid, Spain
Hospital Universitario Infanta Leonor

Madrid, Spain
Hospital Universitario La Paz

Madrid, Spain
Hospital Universitario Virgen del Rocio

Seville, Spain
Hospital Universitario de Gran Canaria Dr. Negrin

Las Palmas de Gran Canaria, Spain
Hospital Universitario y Politecnico La Fe

Valencia, Spain
Institut f. Transfusionsmedizin - Universität Ulm

Ulm, Germany
Ishikawa Prefectural Central Hospital

Kanazawa, 9208530, Japan
Lakes Research

Miami Lakes, Florida, 33014, United States
Ltd M. Zodelava Hematology Centre

Tbilisi, Georgia
Medical University

Vienna, Austria
Osaka University Hospital

Osaka, 5650871, Japan
Royal London Hospital

London, E1 2ES, United Kingdom
Russell Centre for Clinical Haematology

Nottingham, NG5 1PB, United Kingdom
Semmelweis Egyetem

Budapest, Hungary
Shinshu University Hospital

Nagano, Japan
St James' University Hospital

Leeds, LS9 7TF, United Kingdom
St Olavs Hospital, Avdeling for blodsykdommer

Trondheim, Norway
St. Michael's Hospital

Toronto, Canada
Sykehuset Østfold Kalnes

Grålum, Norway
The Oncology Institute of Hope and Innovation

Whittier, California, 90603, United States
UZ Gasthuisberg

Leuven, 3000, Belgium
University of Iowa Hospitals & Clinics - The Hemophilia Treatment Center (HTC)

Iowa City, Iowa, 52242, United States
University of Tsukuba Hospital

Ibaraki, Japan
Universitätsklinikum Essen Klinik f. Hämatologie - Westdeutsches Tumorzentrum

Essen, 45147, Germany
Weill Cornell Medicine / NewYork Presbyterian Hospital

New York, New York, 10021, United States

Conditions

Explore the condition pages connected to this study.

COLD AGGLUTININ DISEASE