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Head-to-Head: which drug works best for sudden joint pain in seniors?

NCT ID NCT03128905

Symptom relief Sponsor: Lille Catholic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two drugs, colchicine and prednisone, to see which works better for sudden, severe joint pain caused by CPPD arthritis (a type of arthritis common in older adults). The trial involved 111 hospitalized patients aged 65 and older. Researchers measured pain relief after 24 hours and tracked side effects. This is the first large, randomized trial to directly compare these treatments for this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
colchicine or prednisone
What this could lead to
If this trial shows one drug is safer or more effective, it could guide doctors in choosing the best treatment for painful CPPD arthritis in older patients.
What could go wrong
This is a relatively small study (111 people) and both drugs have known side effects, especially in elderly patients with other health issues. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

111 people

The number who actually took part.

Started

Feb 2018

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient aged 65 and older * Patient with mono/polyarticular CPPD acute arthritis * Hospitalized patient (without infectious syndrome considered insufficiently controlled by the clinicians and diabetic decompensation) * Diagnosis confirmed : * By the evidence of CPP crystals on synovial fluid examination. * By the existence of a typical clinical arthritis (joint pain, erythema, swelling, maximal intensity in less than 24h) AND presence of chondrocalcinosis signs in knee, wrists, or pubic symphysis on plain X-rays or crowned tooth in cervical rachis scan. * Pain VAS ≥ 40/100 at the enrollment * Duration of symptoms evolution for less than 36h. * No prior intake of oral steroids, colchicine or NSAIDs for this acute arthritis. * Signed patient's consent. * Affiliation to a social security scheme. Exclusion Criteria: * Contraindication to colchicine (creatinine clearance below 30ml/min, severe hepatic dysfunction, macrolide or ongoing pristinamycin or macrolid treatment, …) or corticoids utilization (uncontrolled diabetes, uncontrolled progressive infection, uncontrolled arterial hypertension…) * Severe cognitive disorders that does not allow patient to evaluate his pain. * Patient under guardianship, curatorship * Patient receiving morphinic analgesia. * Gout history or presence of monosodium urate crystals at the examination of the synovial fluid.

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Conditions

The condition(s) this trial relates to.

chondrocalcinosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chondrocalcinosis

Contacts and locations

Locations

  • CH Valenciennes

    Valenciennes, Hauts-de-France, 59322, France

  • CHRU Lille

    Lille, Hauts-de-France, 59000, France

  • Dr Nicolas SEGAUD

    Armentières, 59280, France

  • Dr Rémi LEROY

    Dunkirk, 59240, France

  • Hôpital Bichat

    Paris, Île-de-France Region, 75018, France

  • Hôpital de Lariboisière

    Paris, Île-de-France Region, 75010, France

  • Lille Catholic Hospital

    Lille, Hauts-de-France, 59462, France

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