New antibiotic helper drug shows promise for cystic fibrosis lung infections

NCT ID NCT06159725

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 32 times

Summary

This study tested a new drug called CMTX-101 in 43 adults with cystic fibrosis who have a chronic lung infection. The drug is designed to break down the slimy coating bacteria make, helping standard antibiotics work better. The main goal was to see if it is safe and how the body processes it.

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Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Central Florida Pulmonary Group, PA

    Orlando, Florida, 32803, United States

  • Cystic Fibrosis Institute

    Northfield, Illinois, 60093, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Lenox Hill Hospital

    New York, New York, 10075, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • New York Medical College

    Hawthorne, New York, 10532, United States

  • PennState Health

    Hershey, Pennsylvania, 17003, United States

  • Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • St Luke's Sleep Medicine and Research Center

    Boise, Idaho, 83702, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • UPMC Children's Hospital of Pittsburgh

    Pittsburgh, Pennsylvania, 15224, United States

  • University of Alabama, Birmingham

    Birmingham, Alabama, 35294, United States

  • University of California, San Francisco

    San Franciso, California, 94143, United States

  • University of Kansas

    Kansas City, Kansas, 66160, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Utah

    Salt Lake City, Utah, 84132, United States

  • Vanderbilt University

    Nashville, Tennessee, 37235, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23219, United States

Conditions

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