New combo therapy aims to deepen remission in CML patients
NCT ID NCT03578367
First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 23 times
Summary
This study tested whether adding the experimental drug asciminib to the standard treatment imatinib helps people with chronic myeloid leukemia (CML) achieve a deeper molecular response (very low cancer levels). It included 104 adults who had been on imatinib for at least a year but still had detectable cancer. Participants were randomly assigned to add asciminib, continue imatinib alone, or switch to nilotinib. The goal was to see if the combination leads to better cancer control without needing lifelong medication changes.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Georgia Regents University
Augusta, Georgia, 30912, United States
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Novartis Investigative Site
Vienna, 1140, Austria
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Novartis Investigative Site
Montreal, Quebec, H1T 2M4, Canada
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Novartis Investigative Site
Brno, 625 00, Czechia
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Novartis Investigative Site
Copenhagen, DK-2100, Denmark
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Novartis Investigative Site
Bordeaux, 33076, France
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Novartis Investigative Site
Dresden, 01307, Germany
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Novartis Investigative Site
Milan, MI, 20162, Italy
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Novartis Investigative Site
Roma, RM, 00161, Italy
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Novartis Investigative Site
Krakow, 31 531, Poland
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Novartis Investigative Site
Warsaw, 00-791, Poland
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Novartis Investigative Site
Wroclaw, 50 367, Poland
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Novartis Investigative Site
Lisbon, 1099-023, Portugal
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Novartis Investigative Site
Porto, 4200-072, Portugal
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Novartis Investigative Site
Moscow, 125167, Russia
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Novartis Investigative Site
Moscow, 125284, Russia
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Novartis Investigative Site
Saint Petersburg, 191024, Russia
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Novartis Investigative Site
Saint Petersburg, 197341, Russia
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Novartis Investigative Site
Uijeongbu-si, Gyeonggi-do, 11759, South Korea
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Novartis Investigative Site
Seoul, 06591, South Korea
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Novartis Investigative Site
Badalona, Barcelona, 08916, Spain
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Novartis Investigative Site
Madrid, 28034, Spain
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Novartis Investigative Site
Seville, 41009, Spain
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Novartis Investigative Site
Valencia, 46026, Spain
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Novartis Investigative Site
Changhua, 50006, Taiwan
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Novartis Investigative Site
Taoyuan District, 33305, Taiwan
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Novartis Investigative Site
Liverpool, CH63 4JY, United Kingdom
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Novartis Investigative Site
London, W12 0HS, United Kingdom
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Novartis Investigative Site
Oxford, OX3 7LE, United Kingdom
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Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland, 21205, United States
Conditions
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