New drug combo trial aims to control blood cancer longer

NCT ID NCT03462719

Summary

This study is comparing two different treatment approaches for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who have not received prior treatment. It tests whether a combination of two newer targeted drugs (ibrutinib and venetoclax) works better at keeping the cancer from progressing than a standard chemotherapy-based combination. The goal is to see which treatment helps patients live longer without their cancer getting worse.

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Contacts and locations

Locations

  • Aalborg University Hospital

    Aalborg, 9000, Denmark

  • Aarhus Universitetshospital

    Aarhus, 8200, Denmark

  • Academic Medical Center

    Amsterdam, 1105 AZ, Netherlands

  • Addenbrookes Hospital

    Cambridge, CB2 0QQ, United Kingdom

  • Albert Schweitzer Ziekenhuis

    Dordrecht, 3318 AT, Netherlands

  • Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi

    Ankara, 06620, Turkey (Türkiye)

  • Antonius hospital

    Sneek, 8601 ZK, Netherlands

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Barking Havering and Redbridge University Hospitals NHS Trust

    Romford, RM7 0AG, United Kingdom

  • Birmingham Heartlands Hospital

    Birmingham, B9 5ST, United Kingdom

  • Bnai Zion Medical Center

    Haifa, 31048, Israel

  • CHU Bretonneau

    Tours, 37044, France

  • CHU Montpellier

    Montpellier, 34295, France

  • CHU de Clermont Ferrand

    Clermont-Ferrand, 63000, France

  • CHU-Nancy

    Vandœuvre-lès-Nancy, 54511, France

  • CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Carmel Medical Center

    Haifa, 34362, Israel

  • Catharinaziekenhuis

    Eindhoven, 5623 EJ, Netherlands

  • Centre Hospitalier Universitaire de Reims, Hôpital Robert Debré

    Reims, 51100, France

  • Clinica Univ. de Navarra

    Pamplona, 31008, Spain

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Derriford Hospital

    Plymouth, PL6 8DH, United Kingdom

  • Dokuz Eylul Universitesi Tip Fakultesi

    Izmir, 35340, Turkey (Türkiye)

  • Elisabeth zkh

    Tilburg, 5022 GC, Netherlands

  • FSBIFederal Centre of Heart, Blood and Endocrinology named after V.A.Almazov MoH of the RF

    Saint Petersburg, 197341, Russia

  • Fakultni Nemocnice Ostrava

    Ostrava, 708 52, Czechia

  • Fakultni nemocnice Brno, Interni hematologicka a onkologicka klinika

    Brno, 625 00, Czechia

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • Fakultni nemocnice Plzen, Hemato-onkologicke oddeleni

    Pilsen, 323 00, Czechia

  • Flevoziekenhuis

    Almere Stad, 1315RA, Netherlands

  • Gazi Universitesi Tip Fakultesi

    Ankara, 06500, Turkey (Türkiye)

  • Hadassah Medical Center

    Jerusalem, 9112001, Israel

  • Hopital Claude Huriez

    Lille, 59000, France

  • Hopital Haut Leveque Service Maladie Du Sang

    Pessac, 33604, France

  • Hosp Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp Univ Fund Jimenez Diaz

    Madrid, 28040, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Gral. Univ. Gregorio Maranon

    Madrid, 28007, Spain

  • Hosp. Univ. Infanta Leonor

    Madrid, 28031, Spain

  • Hosp. Univ. de La Princesa

    Madrid, 28006, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Hosp. de La Santa Creu I Sant Pau

    Barcelona, 08041, Spain

  • Hospital Clinico Universitario Salamanca

    Salamanca, 37007, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Institut - Jules Bordet

    Anderlecht, 1070, Belgium

  • Institut Gustave Roussy

    Villejuif, 94805, France

  • Institut Universitaire du Cancer Toulouse Oncopole

    Toulouse, 31059, France

  • Instytut Hematologii i Transfuzjologii

    Warsaw, 02 776, Poland

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • John Theurer Cancer Center

    Hackensack, New Jersey, 07601, United States

  • Juravinski Cancer Centre

    Hamilton, Ontario, L8V 5C2, Canada

  • Karolinska Universitetssjukhuset Solna, Centrum för Hematologi, Stockholm

    Stockholm, 171 76, Sweden

  • MC Haaglanden

    The Hague, 2512 VA, Netherlands

  • Moscow Multidisciplinary Scientific and Clinical Center named after S P Botkin

    Moscow, 125284, Russia

  • New Victoria Hospital

    Glasgow, G42 9LF, United Kingdom

  • Nizhniy Novgorod Region Clinical Hospital

    Nizhny Novgorod, 603126, Russia

  • Norton Cancer Institute

    Louisville, Kentucky, 40207, United States

  • Novant Health

    Charlotte, North Carolina, 28204, United States

  • OLVG

    Amsterdam, 1091AC, Netherlands

  • Odense Universitetshospital

    Odense C, 5000, Denmark

  • Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi

    Samsun, 55280, Turkey (Türkiye)

  • Queen Mary University of London

    Charterhouse Square, EC1M 6BQ, United Kingdom

  • Reinier de Graaf Gasthuis

    Delft, 2625 AD, Netherlands

  • Rigshospitalet

    Copenhagen, 2100, Denmark

  • Roskilde Sygehus

    Roskilde, DK- 4000, Denmark

  • Royal Hallamshire Hospital

    Sheffield, S10 2JF, United Kingdom

  • Ryazan Regional Clinical Hospital

    Ryazan, 390039, Russia

  • S.P. Botkin Moscow City Clinical Hospital

    Moscow, 125284, Russia

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespol Szpitali Miejskich

    Chorzów, 41-500, Poland

  • Sheba Medical Center

    Ramat Gan, 52621, Israel

  • Spaarne Gasthuis

    Hoofddorp, 2134 TM, Netherlands

  • St James's Hospital

    Leeds, LS9 7T, United Kingdom

  • St.-Petersburg Clinical Research Institute of Hematology and Transfusiology

    Saint Petersburg, 193024, Russia

  • Sunderby Sjukhus Medicinkliniken

    Luelå, 97180, Sweden

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 64239, Israel

  • The Ottawa Hospital - General Campus

    Ottawa, Ontario, K1H 8L6, Canada

  • UZ Leuven Gasthuisberg

    Leuven, 3000, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie

    Lublin, 20-081, Poland

  • V K V Amerikan Hastanesi

    Istanbul, 34365, Turkey (Türkiye)

  • Virga Jessa Ziekenhuis

    Hasselt, 3500, Belgium

  • Vseobecna fakultni nemocnice v Praze - I. interni klinika - klinika hematologie

    Prague, 128 08, Czechia

  • Western Galilee Medical Center

    Nahariya, 22100, Israel

  • Wojewodzki Szpital Specjalistyczny im Janusza Korczaka

    Słupsk, 76-200, Poland

  • Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im M Kopernika w Lodzi

    Lodz, 93 510, Poland

  • ZNA Stuivenberg

    Antwerp, 2060, Belgium

  • Zuyderland Medical Center

    Sittard-Geleen, 6162 BG, Netherlands

Conditions

Explore the condition pages connected to this study.