Common heartburn drug tested as potential lifeline for rare, painful sunlight disorder
NCT ID NCT05020184
Summary
This study tested whether cimetidine, a common heartburn medication, could help people with rare genetic disorders (EPP and XLP) that cause severe, painful reactions to sunlight. In this Phase 2 trial, 26 participants took either cimetidine or a placebo for three months to see if it reduced the harmful light-sensitive substance in their blood and improved their ability to tolerate light. The goal was to find a safe, repurposed drug to control this lifelong condition and prevent serious complications like liver damage.
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Contacts and locations
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Locations
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Atrium Health Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, 27157, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Texas Medical Branch
Galveston, Texas, 77555, United States
Conditions
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