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New drug trial offers hope for teens battling genetic high cholesterol

NCT ID NCT04652726

Completed Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study tested a drug called inclisiran in teenagers with a genetic condition that causes very high cholesterol. For the first year, some participants received the drug and others received a placebo, while all continued their standard cholesterol medications. The main goal was to see if inclisiran was safe and more effective than a placebo at lowering 'bad' LDL cholesterol over nearly a year.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Childrens Hospital Pittsburgh of UPMC

    Pittsburgh, Pennsylvania, 15224, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229-3039, United States

  • Far Eastern Memorial Hospital

    New Taipei City, 22060, Taiwan

  • Gazi University Medical Faculty

    Ankara, 06500, Turkey (Türkiye)

  • Heart Institute (InCOr) HCMFUSP

    São Paulo, São Paulo, 05403 000, Brazil

  • Hippokrateion General Hospital of Athens Greece

    Athens, 115 27, Greece

  • Hospital Abente y Lago

    A Coruña, 15001, Spain

  • Hospital Central de Asturias

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Reina Sofia

    Córdoba, Andalusia, 14004, Spain

  • Hospital Virgen de la Vcitoria

    Málaga, Andalusia, 29010, Spain

  • Hotel Dieu de France Hospital

    El Achrafiyé, 166830, Lebanon

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Institute of Internal Prev. Med.

    Novosibirsk, 630090, Russia

  • Institute of the complex problems of cardiovascular disease

    Kemerovo, 650002, Russia

  • KKIM UK Frankfurt/Main

    Frankfurt, 60590, Germany

  • Lipid Research

    Jerusalem, 9112001, Israel

  • Lipids Center Sheba Medical Center, Israel

    Ramat Gan, 52621, Israel

  • Metropolitan Hospital

    Athens, 18547, Greece

  • Novartis Investigative Site

    Formosa, Formosa Province, P3600, Argentina

  • Novartis Investigative Site

    Québec, Quebec, G1V 4W2, Canada

  • Novartis Investigative Site

    Prague, 12808, Czechia

  • Novartis Investigative Site

    Prague, 150 06, Czechia

  • Novartis Investigative Site

    Besançon, 25030, France

  • Novartis Investigative Site

    Bron, 69677, France

  • Novartis Investigative Site

    Toulouse, 31059, France

  • Novartis Investigative Site

    Pécs, 7623, Hungary

  • Novartis Investigative Site

    Milan, MI, 20162, Italy

  • Novartis Investigative Site

    Modena, MO, 41124, Italy

  • Novartis Investigative Site

    Roma, RM, 00161, Italy

  • Novartis Investigative Site

    Roma, RM, 00165, Italy

  • Novartis Investigative Site

    Irbid, 22110, Jordan

  • Novartis Investigative Site

    Rotterdam, South Holland, 3015 GD, Netherlands

  • Novartis Investigative Site

    Amsterdam, 1105 AZ, Netherlands

  • Novartis Investigative Site

    Oslo, 0514, Norway

  • Novartis Investigative Site

    Gdansk, 80 952, Poland

  • Novartis Investigative Site

    Lodz, 93-338, Poland

  • Novartis Investigative Site

    Moscow, 127412, Russia

  • Novartis Investigative Site

    Poprad, 058 01, Slovakia

  • Novartis Investigative Site

    Bloemfontein, Free State, 9301, South Africa

  • Novartis Investigative Site

    Somerset West, Western Cape, 7130, South Africa

  • Novartis Investigative Site

    Cape Town, 7925, South Africa

  • Novartis Investigative Site

    Pamplona, Navarre, 31008, Spain

  • Novartis Investigative Site

    Geneva, 1211, Switzerland

  • Novartis Investigative Site

    Istanbul, TUR, 34098, Turkey (Türkiye)

  • Novartis Investigative Site

    Adana, 01330, Turkey (Türkiye)

  • Novartis Investigative Site

    Izmir, 35100, Turkey (Türkiye)

  • Novartis Investigative Site

    Middlesex, UB9 6JH, United Kingdom

  • Nucleo de Pesquisa Clinica do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

  • Primary Children's Medical Center

    Salt Lake City, Utah, 84113, United States

  • Setor de Lípides, Aterosclerose e Biologia

    São Paulo, São Paulo, 04023-900, Brazil

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Tucson Medical Center

    Tucson, Arizona, 85712, United States

  • UiTM Sungai Buloh

    Sungai Buloh, Selangor, 47000, Malaysia

  • Unidade de pesquisa clinica - Hospital Universitario Walter Cantidio

    Fortaleza, Ceará, 60430275, Brazil

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitaetsmedizin Mannheim

    Mannheim, Baden-Wurttemberg, 68305, Germany

  • University General Hospital of Ioannina

    Ioannina, GR, 455 00, Greece

  • University Medical Centre Ljubljana, Div. of Pediatric Dept. of Endocrinology, Diabetes and Metabolic Diseases

    Ljubljana, 1000, Slovenia

  • Wake Forest U of Health Sciences

    Winston-Salem, North Carolina, 27157, United States

Conditions

Explore the condition pages connected to this study.

FAMILIAL HYPERCHOLESTEROLEMIA - HETEROZYGOUS