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Which mouthwash fights plaque better: chlorhexidine or essential oils?

NCT ID NCT07822256

Disease control Sponsor: Rehman Medical Institute - RMI Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers compare two common mouthwashes to see which reduces dental plaque more effectively in young patients with gum inflammation. Sixty patients aged 15 to 25 use either a chlorhexidine rinse or an essential oil rinse twice daily for three months. The team measures plaque on six teeth at the start and after three months, and tracks side effects like taste changes, tooth staining, or mouth burning. The goal is to help patients and dentists weigh stronger plaque control against comfort for longer-term use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
chlorhexidine gluconate mouthwash and essential oil mouthwash
What this could lead to
If one mouthwash controls plaque better with fewer side effects, dentists could give clearer guidance on which rinse suits short-term gum care.
What could go wrong
This is a small, single-center study of 60 young patients with mild gum inflammation, so the results may not apply to older adults or people with more advanced gum disease. Chlorhexidine can stain teeth and alter taste, while essential oils may irritate the mouth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Feb 2026

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 15-25 years 2. Diagnosis of gingivitis (inflammatory condition of the gums without attachment or bone loss) 3. Willingness to provide written informed consent (or parental/guardian consent plus assent, for minors) Exclusion Criteria: 1. Periodontitis 2. Known allergy or hypersensitivity to chlorhexidine 3. Any systemic disease that could affect periodontal health 4. Current antibiotic therapy 5. Presence of anterior composite restorations 6. Visible enamel decalcification

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Conditions

The condition(s) this trial relates to.

Dental Plaque gingivitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental plaque Gingivitis infection

Contacts and locations

Locations

  • Rehman Medical Institute - RMI

    Peshawar, Pakistan

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