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Can MRI scans reveal the hidden fluid dynamics behind chiari malformation?

NCT ID NCT06502431

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This study uses special MRI scans to measure the flow of cerebrospinal fluid and blood in the brain and spine of people with Chiari malformation. The goal is to see how these flows differ between people with symptoms and those without. Researchers will compare these measurements with a control group of healthy volunteers. The findings may help explain what causes symptoms and guide future treatment decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Phase contrast MRI sequences added to standard MRI to measure cerebrospinal fluid and blood flow
What this could lead to
If this works, it could improve understanding of Chiari malformation and help guide treatment decisions.
What could go wrong
This is an observational imaging study, not a treatment trial. It may not lead to immediate clinical changes, and MRI results may not fully explain symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients with major symptomatic or nonsymptomatic CMI * aged 18 to 50 years * no previous neurosurgical, neurological, or cardiological history. * Controls should be age-matched to symptomatic CMI group. They should not have a history of neurosurgery, neurology, or cardiology. Exclusion Criteria: * Patients who are minors or over 50 years of age * CMI invalidated by our radiological review * Neurosurgical, neurological or cardiological history * MRI contraindication * pregnant, breast-feeding and parturient women

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Conditions

The condition(s) this trial relates to.

Chiari malformation Chiari malformation type I

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral hemodynamic Cerebrospinal fluid Craniospinal hydrodynamic Phase contrast mri Type I Chiari malformation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Amiens Picardie

    RECRUITING

    Amiens, Picardie, 80054, France

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