Immunotherapy combo shows promise in advanced cervical cancer trial

NCT ID NCT03556839

Completed Disease control Sponsor: Grupo Español de Investigación en Cáncer de Ovario Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and bevacizumab helps women with advanced, persistent, or recurrent cervical cancer live longer. The study enrolled 410 participants and compared the new combination against the current standard treatment. Researchers measured progression-free and overall survival to see if the added drug makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Atezolizumab (Tecentriq) plus bevacizumab (Avastin) and chemotherapy (cisplatin or carboplatin with paclitaxel)

What this could lead to

If successful, this combination could become a new standard treatment option for women with advanced or recurrent cervical cancer, potentially improving survival.

What could go wrong

This trial is completed, but results may not show a significant benefit over the current standard. Adding immunotherapy also increases the risk of immune-related side effects.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

carcinoma cervical cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA OF THE CERVIX, STAGE IVB

Contacts and locations

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Locations

AOU Città della Salute e della Scienza di Torino, Presidio Sant'Anna

Torino, Italy
ASST Lecco

Lecco, Italy
AUSL Romagna - P.O. di Ravenna, Lugo, Faenza, Rimini e Cattolica

Ravenna, Italy
Azienda Ospedaliero Universitaria Pisana

Pisa, Italy
Azienda Ospedaliero-Universitaria Di Ferrara

Ferrara, Italy
Azienda Sanitaria Universitaria Integrata Di Udine

Udine, Italy
Azienda Usl - Irccs Di Reggio Emilia

Reggio Emilia, Italy
CHU Jean Minjoz

Besançon, France
Cancer Institute Hospital

Kōtoku, Japan
Centre Antoine Lacassagne

Nice, France
Centre CARIO-HPCA

Plérin, France
Centre François Baclesse

Caen, France
Centre Hospitalier Lyon Sud

Pierre-Bénite, France
Centre Léon Bérard

Lyon, France
Centre Oscar Lambret

Lille, 59000, France
Complejo Hospitalario Regional de Málaga

Málaga, Málaga, 29010, Spain
Fondazione Del Piemonte Per L'Oncologia

Candiolo, Italy
Groupe Hospitalier Diaconesses-Croix Saint-Simon

Paris, France
Gustave Roussy

Villejuif, France
H. Clínic Barcelona

Barcelona, Barcelona, 08036, Spain
HEGP

Paris, France
Haukeland University Hospital

Bergen, Norway
Helios-Klinikum Wuppertal

Wuppertal, 42283, Germany
Hokkaido Cancer Center

Hokkaido, Japan
Hospital Clinico Universitario Virgen Arrixaca

Murcia, Murcia, 30120, Spain
Hospital Clínico Universitario de Valencia

Valencia, Valencia, 46010, Spain
Hospital Miguel Servet

Zaragoza, Zaragoza, 50009, Spain
Hospital Quirón de Valencia

Valencia, 46010, Spain
Hospital Ramon y Cajal

Madrid, Madrid, 28034, Spain
Hospital Reina Sofía Cordoba

Córdoba, Cordoba, 14004, Spain
Hospital Universitario 12 de Octubre

Madrid, Madrid, 28041, Spain
Hospital Universitario Donostia- Donostia Unibertsitate Ospitalea

Donostia / San Sebastian, Gipuzkoa, 20014, Spain
Hospital Universitario La Paz

Madrid, Madrid, 28046, Spain
Hospital Universitario Son Espases

Palma de Mallorca, Balearic Islands, 07120, Spain
Hospital Virgen de la Salud

Toledo, 45004, Spain
Hospital de la Vall d'Hebron

Barcelona, Barcelona, 08035, Spain
Hosptial Clinico Universitario de Santiago de Compostela

Santiago de Compostela, Santiago de Compostela, 15706, Spain
Hyogo Cancer Center

Hyōgo, Japan
Hôpital Privé du Confluent S.A.S.

Nantes, France
Hôpitaux Universitaires

Strasbourg, France
ICM Val d'Aurelle

Montpellier, France
ICO Centre René Gauducheau

Saint-Herblain, France
ICO Girona

Girona, Girona, 17007, Spain
ICO Paul Papin

Angers, 49055, France
Institut Bergonié

Bordeaux, France
Institut Claudius Régaud

Toulouse, France
Instituto Valenciano de Oncología

Valencia, Valencia, 46009, Spain
Intitut Català d' Oncolgia L' Hospitalet

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Irccs S. Raffaele - Milano

Milan, Italy
Irst Irccs

Meldola FC, Italy
Istituto Europeo di Oncologia

Milan, Italy
Istituto Nazionale Tumori Di Napoli Irccs Pascale

Naples, Italy
Istituto Oncologico Veneto (IOV) IRCCS

Padova, Italy
Karolinska University Hospital

Stockholm, Sweden
Keio University Hospital

Tokyo, Japan
Kurume University Hospital

Fukuoka, Japan
Lindköping University Hospital

Linköping, Sweden
Massey Cancer Center

Richmond, Virginia, 980037, United States
Niigata University Medical & Dental Hospital

Niigata, Japan
Oslo University Hospital

Oslo, Norway
Ospedale Lecce 'Vito Fazzi'

Lecce, Italy
Ospedale Ordine Mauriziano

Torino, Italy
Ospedale San Gerardo

Monza, Italy
Parc Taulí

Sabadell, Barcelona, 08208, Spain
Policlinico Universitario A. Gemelli

Roma, Italy
Saitama medical university international medical center

Hidaka, Japan
Shizuoka Cancer Center

Shizuoka, Japan
Skane University Hospital

Lund, Sweden
University Hospital of North Norway

Tromsø, Norway
Universitätsmedizin Mainz

Mainz, 55131, Germany
Uppsala University Hospital

Uppsala, Sweden
Willis Knighton Cancer Center

Shreveport, Louisiana, 71103, United States