New radiation technique aims to spare cervical cancer patients from gut woes

NCT ID NCT05197881

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This trial tests a new type of radiation therapy for cervical cancer that adjusts the beam daily based on the patient's anatomy. The goal is to reduce acute bowel side effects like diarrhea and urgency. About 125 patients with advanced cervical cancer will receive this treatment, and their reported side effects will be compared to historical rates from standard radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Daily adaptive external beam radiation therapy delivered via Varian Ethos system
What this could lead to
If successful, this approach could reduce acute gastrointestinal side effects like diarrhea and urgency during radiation for cervical cancer, making treatment more tolerable.
What could go wrong
This is an early-phase, single-arm study comparing results to historical data, not a randomized trial. The new technique may not significantly reduce side effects or could have unforeseen issues.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Moores Cancer Center at UC San Diego Health

    RECRUITING

    La Jolla, California, 92037, United States

  • University of Alabama Birmingham

    RECRUITING

    Burmingham, Alabama, 35233, United States

  • University of Arkansas Medical Sciences

    RECRUITING

    Little Rock, Arkansas, 72205, United States

  • University of Texas Southwestern

    RECRUITING

    Dallas, Texas, 75390, United States

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