Cannabis-Derived drug tested for brain symptoms in rare genetic disorder

NCT ID NCT05864846

Summary

This study is checking if adding the prescription CBD medication Epidiolex to existing anti-seizure drugs helps improve behavior problems, sleep, and quality of life in people with tuberous sclerosis complex (TSC). It will include up to 79 participants, aged 1 to 65, who have TSC and moderate to severe behavioral issues alongside their seizures. Researchers will track changes in behavior, sleep, family impact, and seizure frequency over time.

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Contacts and locations

Locations

  • Alberta Children's Hospital

    Calgary, Alberta, T3B 6AB, Canada

  • Atrium Health Wake Forest Baptist Medical Center

    Winston-Salem, North Carolina, 27157, United States

  • BC Children's Hospital

    Vancouver, British Columbia, V6H 3V4, Canada

  • Children's Hospital Colorado

    Aurora, Colorado, 80045, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Evelina London Children's Hospital Guys St Thomas' NHS Foundation Trust, the Guy's Hospital

    London, England, SE1 7EH, United Kingdom

  • Le Bonheur Children's Hospital

    Memphis, Tennessee, 38103, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Minnesota Epilepsy Group

    Roseville, Minnesota, 55113, United States

  • Nicklaus Children's Health, Miami

    Miami, Florida, 33155, United States

  • Sheffield Children's NHS Foundation Trust

    Sheffield, 2TH, United Kingdom

  • The Children's Memorial Health Institute

    Warsaw, 04-736, Poland

  • The Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • University Hospitals Bristol NHS Foundation Trust

    Bristol, BS1 3NU, United Kingdom

  • University of Florida Health - Department of Neurology

    Gainesville, Florida, 32608, United States

  • University of Texas Health Science Center - San Antonio

    San Antonio, Texas, 78229, United States

  • University of Texas Health Science Center at Houston - Clinical Research Unit

    Houston, Texas, 77030, United States

  • University of Virginia, Charlottesville

    Charlottesville, Virginia, 22903, United States

  • Yale University School of Medicine

    New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.