Gene-Edited immune cells take on Hard-to-Treat blood cancer

NCT ID NCT05722418

Recruiting now Disease control Sponsor: Caribou Biosciences, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new treatment called CB-011 for people with multiple myeloma that has returned or stopped responding to other therapies. CB-011 uses CRISPR gene editing to create donor immune cells that target and attack cancer cells. The study aims to find the safest dose and check if the treatment shrinks tumors, involving about 50 participants.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY MULTIPLE MYELOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

CU Anschutz Medical Campus, Anshutz Cancer Pavillion
RECRUITING

Aurora, Colorado, 80045, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States

Contact Email: •••••@•••••
Duke University Health System (DUHS)
RECRUITING

Durham, North Carolina, 27705, United States
Froedtert and the Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Hackensack Meridian John Theurer Cancer Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Oncology Hematology Care, Inc
RECRUITING

Cincinnati, Ohio, 45236, United States
Sylvester Comprehensive Cancer Center, University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of Kentucky/ Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23235, United States

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