Next-gen CART therapy targets stubborn leukemia that evades first-line treatment
NCT ID NCT04016129
First seen Apr 25, 2026 · Last updated Jun 15, 2026 · Updated 8 times
Summary
This study tests a new type of CART immunotherapy for people with B-cell acute lymphoblastic leukemia (ALL) whose cancer cells do not have the CD19 marker, either from the start or after previous CD19-targeted CART therapy. The treatment uses a patient's own immune cells, modified to attack multiple cancer markers (CD22, CD123, CD38, CD10, CD20, and TSLPR) to overcome resistance. The trial enrolls 100 participants aged 6 months and older across multiple centers to evaluate safety and anti-cancer activity.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shenzhen Geno-immune Medical Institute
RECRUITINGShenzhen, Guangdong, 518000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhongxi Children Hospital
RECRUITINGShijiazhuang, Hebei, 050006, China
Contact
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Zhujiang Hospital of Southern Medical University
RECRUITINGGuangzhou, Guangdong, 510282, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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