CAR-T therapy trial offers new hope for Tough-to-Treat lymphoma
NCT ID NCT03391466
Summary
This study tested whether a personalized immune cell therapy (called axicabtagene ciloleucel or CAR-T) works better than standard second-line treatments for patients with a fast-growing type of lymphoma that has returned or not responded to initial chemotherapy. It involved 359 adults whose cancer had relapsed within a year of first treatment. The main goal was to see if the CAR-T therapy helped patients live longer without their cancer getting worse.
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Contacts and locations
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Locations
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Academic Medical Center
Amsterdam, 1105 AZ, Netherlands
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Banner MD Anderson Cancer Center
Gilbert, Arizona, 85234, United States
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Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Barts Health NHS Trust
London, EC1A 7BE, United Kingdom
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CHRU de Lille - Hopital Claude Huriez
Lille, 59037, France
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CHU de Quebec-Universite Laval, Hopital de L'Enfante-Jesus
Québec, G1J 1Z4, Canada
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CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
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Centre Hospitalier Lyon-Sud - Service d'Hematologie clinique
Pierre-Bénite, 69495, France
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Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou
Rennes, 35033, France
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Centre Integre Universitaire de Sante et Services Sociaux de l'Est-de-l'lle-de-Montreal / Hopital Maisonneuve-Rosemont
Montreal, H1T 2M4, Canada
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Clinica Universidad de Navarra
Pamplona, 31008, Spain
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Cliniques Universiaires Saint-Luc
Brussels, Belgium
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Erasmus Medical Center
Rotterdam, 3011PL, Netherlands
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Henry-Joyce Cancer Center
Nashville, Tennessee, 37232, United States
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Hopital Saint-Louis
Paris, 75010, France
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Hospital Universitario de Salamanca
Salamanca, 37007, Spain
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IOSI, OSpedale Regionale Bellinzona e Valli
Bellinzona, 6500, Switzerland
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IRCCS Ospedale San Raffaele di Milano
Milan, 20132, Italy
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Icahn School of Medicine at Mount Sinai
New York, New York, 10029, United States
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Institut Catala d'Oncologia
Barcelona, 08908, Spain
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Instituto di Ematologia "L. e A. Seragnoli" - Dipartimento di Medicina Specialistica Diagnostica e Sperimentale
Bologna, 40138, Italy
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James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Mayo Clinic Hospital
Phoenix, Arizona, 85054, United States
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Mayo Clinic, Patient Location
Rochester, Minnesota, 55905, United States
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McGill University Health Center
Montreal, Quebec, H4A 3J1, Canada
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Medizinische Universitat Innsbruck, Innere Medizin V - Hamatologie und Onkologie
Innsbruck, 6020, Austria
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Memorial Sloan Kettering Cancer Center
New York, New York, 10021, United States
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Moffitt Cancer Center
Tampa, Florida, 12902, United States
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Northwestern University
Chicago, Illinois, 60612, United States
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Peter MacCallum Cancer Center
Melbourne, Victoria, 3000, Australia
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QEII Health Sciences Centre
Halifax, B3H 2Y9, Canada
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Sarah Cannon Research Institute
Nashville, Tennessee, 37203, United States
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Stanford Cancer Institute
Stanford, California, 94305, United States
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Swedish Cancer Institute
Seattle, Washington, 98104, United States
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Tel Aviv Sourasky Medical Center
Tel Aviv, 6423906, Israel
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The Christie NHS Foundation Trust
Manchester, M20 4BX, United Kingdom
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The Ottawa Hospital - General Campus
Ottawa, K1H 8L6, Canada
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The Royal Marsden NHS Foundation Trust
Sutton, SM2 5PT, United Kingdom
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The University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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The University of Texas, MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Thomas Jefferson University
Philadelphia, Pennsylvania, 19107, United States
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UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
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UCLA
Santa Monica, California, 90404, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15213, United States
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UZ Gasthuisberg
Leuven, Belgium
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Uninversity Health Network - Princess Margaret Cancer Center
Toronto, Ontario, M5G 2M9, Canada
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Universitatsklinikum Graz, Division of Hematology
Graz, 6020, Austria
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Universitatsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
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Universitatsmedizin Gottingen
Göttingen, 37075, Germany
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University College London Hospitals NHS Foundation Trust
London, NW3 2QG, United Kingdom
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University Hospital Zurich
Zurich, 8091, Switzerland
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University Hospitals Birmingham NHS Foundation Trust
Birmingham, B15 2GW, United Kingdom
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University Medical Center Groningen
Groningen, 9700 RB, Netherlands
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University Medical Center Utrecht
Utrecht, Netherlands
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University of Chicago Medical Center
Chicago, Illinois, 60637, United States
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University of Iowa Hospitals and Clinincs
Iowa City, Iowa, 52242, United States
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University of Maryland, Greenbaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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University of Miami Hospital and Clinics/Sylvester Comprehensive Cancer Center
Miami, Florida, 33136, United States
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University of Rochester Medical Center
Rochester, New York, 14642, United States
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University of Utah, Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
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University of Virginia Health System
Charlottesville, Virginia, 22908, United States
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Universitäts-klinikum Dresden
Dresden, 01307, Germany
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Universitäts-klinikum Würzburg
Würzburg, 97080, Germany
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Universitätsklinikum Heidelberg
Heidelberg, 69120, Germany
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Uppsala Akademiska Sjukhus
Uppsala, 75185, Sweden
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Vancouver General Hospital
Vancouver, British Columbia, Canada
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Washington University School of Medicine
St Louis, Missouri, 63130, United States
Conditions
Explore the condition pages connected to this study.