Experimental cell therapy tested as last hope for rare cancers
NCT ID NCT05537766
Summary
This study tested an experimental cell therapy called brexucabtagene autoleucel in adults with rare and aggressive types of B-cell blood cancers that had returned or stopped responding to standard treatments. The therapy, known as CAR-T, involves genetically modifying a patient's own immune cells to attack their cancer. The study was terminated early by the sponsor after enrolling 19 participants across several rare cancer types.
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Contacts and locations
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Locations
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ASST Grande Ospedale Metropolitano Niguarda
Milan, 20162, Italy
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Azienda Ospedale di Perugia - Ospedale S. Maria della Misericordia
Perugia, 06132, Italy
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Centre hospitalier de Toulouse - Hematology department
Toulouse, 31059, France
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City of Hope (City of Hope National Medical Center)
Duarte, California, 91010, United States
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Colorado Blood Cancer Institute
Denver, Colorado, 80218, United States
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Georgetown University Medical Centre
Washington D.C., District of Columbia, 20037, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Hopital de la Pitie Salpetriere
Paris, 75013, France
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
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Hospital Universitario de Salamanca
Salamanca, 37007, Spain
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IRCCS Azienda Ospedaliero - Universitaria di Bologna
Bologna, 40138, Italy
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Istituto Oncologico Della Svizzera Italiana (IOSI)
Bellinzona, 6500, Switzerland
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Medical University of Vienna, Department of Internal Medicine I, Div. of Hematology
Vienna, 01090, Austria
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Radboud University Nijmegen Medical Centre
Nijmegen, 6525 GA, Netherlands
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Stanford Cancer Institute
Stanford, California, 94305, United States
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Tennessee Oncology, PLLC
Nashville, Tennessee, 37203, United States
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The Ohio State University Wexner Medical Center - James Cancer HospitalS
Columbus, Ohio, 43210, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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Universitatsklinikum Heidelberg
Heidelberg, 69120, Germany
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Universitatsklinikum Koln
Cologne, 50937, Germany
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Universitatsklinikum Ulm
Ulm, 89081, Germany
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University of Iowa
Iowa City, Iowa, 52242, United States
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Vanderbilt University
Nashville, Tennessee, 37232, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
Conditions
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