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CAR-T therapy trial offers new hope for patients with stubborn blood cancer

NCT ID NCT05371093

Ongoing Disease control Sponsor: Kite, A Gilead Company Source: ClinicalTrials.gov ↗

Summary

This study is testing a personalized immune cell therapy called axicabtagene ciloleucel (a type of CAR-T therapy) against standard treatments for follicular lymphoma that has come back or stopped responding to previous therapies. It involves about 230 participants and aims to see if this advanced therapy can better control the cancer and help patients live longer without their disease getting worse. The study is in its final Phase 3 stage, which means it's directly comparing this new approach to current best practices.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • ASST Papa Giovanni XXIII

    Bergamo, 24128, Italy

  • Arcispedale Santa Maria Nuova

    Reggio Emilia, 42123, Italy

  • Azienda Ospedallero-Universitaria di Bologna Policlinico Sant'Orsola-Malpighi

    Bologna, 40138, Italy

  • CHU Bordeaux - Hospital Haut-Leveque - Centre Francois Magendie

    Pessac, 33604, France

  • CHU de Dijon

    Dijon, 21079, France

  • CHU de Poitiers

    Poitiers, 86021, France

  • Cambridge University Hospitals NHS Foundation Trust

    Cambridge, CB2 2QQ, United Kingdom

  • Centre Henri Becquerel

    Rouen, 76038, France

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center)

    Duarte, California, 91010, United States

  • Dana-Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Fondazione IRCCS - Istituto Nazionale Tumori

    Milan, 20100, Italy

  • Henry-Joyce Cancer Clinic

    Nashville, Tennessee, 37232, United States

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Pitie-Salpetriere

    Paris, 75013, France

  • Hopital Pontchaillou - CHU Rennes

    Rennes, 35033, France

  • Hopital Saint Eloi

    Montpellier, 34295, France

  • Hospital 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Universitario Gregorio Maranon

    Madrid, 28009, Spain

  • Hospital Universitari Vall d'Hebrón

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital Universitario de Salamanca

    Salamanca, 37007, Spain

  • Hyogo Medical University Hospital

    Hyōgo, 663-8501, Japan

  • Hôpital Claude Huriez-CHU de Lille

    Lille, 59037, France

  • Institut Paoli-Calmettes

    Marseille, 13273, France

  • Instituto Catalan de Oncologia - Hospital Duran i Reynolds (ICO L'Hospitalet)

    Barcelona, 08908, Spain

  • Istituto Clinico Humanitas-IRCCS

    Rozzano, 20089, Italy

  • King's College Hospital NHS Foundation Trust

    London, SE5 9RS, United Kingdom

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Novant Health Cancer Institute Hematology - Charlotte

    Charlotte, North Carolina, 28204, United States

  • Okayama University Hospital

    Okayama, 700-8558, Japan

  • Osaka University Hospital

    Osaka, 565-0871, Japan

  • Ospedale San Raffaele

    Milan, 20132, Italy

  • Oxford University Hospitals NHS Foundation Trust

    Oxford, OX3 7LE, United Kingdom

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

  • Stanford Health Care

    Stanford, California, 94305, United States

  • The Christie NHS Foundation Trust

    Manchester, M20 4BX, United Kingdom

  • The Royal Marsden NHS Foundation Trust

    Sutton, SM2 5PT, United Kingdom

  • The University Hospital Southampton NHS Foundation Trust

    Southampton, SO16 6YD, United Kingdom

  • The University of Kansas Hospital

    Westwood, Kansas, 66205, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Tohoku University Hospital

    Miyagi, 980-8574, Japan

  • TriStar Centennial Medical Center - Cell Processing

    Nashville, Tennessee, 37203, United States

  • Universitatsklinikum Koln Klinik I fur Innere Medizin

    Würzburg, 97080, Germany

  • Universitatsmedizin Gottingen

    Göttingen, 37075, Germany

  • University College London Hospitals NHS Foundation Trust

    London, NW2 2QG, United Kingdom

  • University Hospital Birmingham NHS Foundation Trust

    Birmingham, B15 2GW, United Kingdom

  • University Hospital Kyoto Prefectural University of Medicine

    Kyoto, 602-8566,, Japan

  • University of Maryland Greenebaum Comprehensive Cancer Center

    Baltimore, Maryland, 21201, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

Conditions

Explore the condition pages connected to this study.

RELAPSED/REFRACTORY FOLLICULAR LYMPHOMA