New hope for kids with Tough-to-Treat leukemia: experimental immune therapy trial
NCT ID NCT03876769
Summary
This study is testing an experimental immune therapy called tisagenlecleucel (a type of CAR-T cell therapy) in children and young adults (ages 1-25) with high-risk B-cell acute lymphoblastic leukemia (B-ALL). The treatment is for patients who still show small amounts of cancer cells after completing their initial chemotherapy. Researchers want to see if this one-time infusion of genetically modified immune cells can help keep the cancer from coming back and improve survival without needing a stem cell transplant.
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Contacts and locations
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Locations
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Children s Hospital of Alabama
Birmingham, Alabama, 35233, United States
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Children s Mercy Hospital
Kansas City, Missouri, 64108, United States
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Childrens Healthcare of Atlanta
Atlanta, Georgia, 30342, United States
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Childrens Hospital Colorado
Aurora, Colorado, 80045, United States
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Childrens Hospital Los Angeles
Los Angeles, California, 90027, United States
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Childrens Hospital of Orange County
Orange, California, 92868-3874, United States
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Childrens Hospital of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Childrens National Hospital
Washington D.C., District of Columbia, 20010, United States
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Cinn Children Hosp Medical Center
Cincinnati, Ohio, 45229-3039, United States
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City of Hope National Medical
Duarte, California, 91010, United States
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Columbia University Medical Center
New York, New York, 110032, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Hackensack Uni Medical Center
Hackensack, New Jersey, 07601, United States
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James Whitcomb Riley Hospital For Children
Indianapolis, Indiana, 46202, United States
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Johns Hopkins All Childrens
St. Petersburg, Florida, 33701, United States
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Johns Hopkins Oncology Center
Baltimore, Maryland, 21231, United States
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Mattel Childrens Hospital UCLA
Los Angeles, California, 90095, United States
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Memorial Sloan Kettering Cancer Ctr
New York, New York, 10065, United States
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Methodist Childrens Hospital
San Antonio, Texas, 78229, United States
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Novartis Investigative Site
Ghent, 9000, Belgium
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Novartis Investigative Site
Calgary, Alberta, T3B6A8, Canada
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Novartis Investigative Site
Toronto, Ontario, M5G 1X8, Canada
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Novartis Investigative Site
Montreal, Quebec, H3T 1C5, Canada
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Novartis Investigative Site
Copenhagen, DK-2100, Denmark
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Novartis Investigative Site
Paris, 75019, France
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Novartis Investigative Site
Roma, RM, 00165, Italy
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Novartis Investigative Site
Utrecht, 3584 CS, Netherlands
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Novartis Investigative Site
Oslo, 0424, Norway
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Novartis Investigative Site
Esplugues, Barcelona, 08950, Spain
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Novartis Investigative Site
Gothenburg, SE 416 85, Sweden
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Novartis Investigative Site
London, NW1 2BU, United Kingdom
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Novartis Investigative Site
London, WC1N 3JH, United Kingdom
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Oregon Health and Science University
Portland, Oregon, 97239-3098, United States
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Phoenix Childrens Hospital
Phoenix, Arizona, 85016, United States
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Prinses Maxima Centrum voor Kinderoncologie
Utrecht, CS, 3584, Netherlands
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Rady Children s Hospital
San Diego, California, 92123, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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Stanford University Medical Center
Stanford, California, 94304, United States
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Texas Childrens Cancer and Hematology Center
Houston, Texas, 77030, United States
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The Childrens Hosp of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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UCSF Medical Center
San Francisco, California, 94143, United States
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Univ of Texas Southwest Med Center
Dallas, Texas, 75390-9034, United States
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University of Utah Clinical Trials Office
Salt Lake City, Utah, 84108, United States
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University of Wisconsin Hospital and Clinics Pharmacy/Drug Shipping Address
Madison, Wisconsin, 53792, United States
Conditions
Explore the condition pages connected to this study.