New hope to tame CAR-T's dangerous brain side effects

NCT ID NCT04150913

Summary

This study tested whether adding a drug called anakinra to a powerful cell therapy (CAR-T) could reduce severe brain-related side effects in patients with lymphoma that has returned or resisted treatment. The main goal was to see if this combination made the CAR-T treatment safer by lowering the rates of confusion, seizures, and other nervous system problems. Researchers enrolled 15 adults to receive both treatments and monitored them closely.

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Contacts and locations

Locations

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02115, United States

Conditions

Explore the condition pages connected to this study.