CAR-T therapy trial aims to tame devastating autoimmune attack

NCT ID NCT06868290

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing a new type of treatment called rapcabtagene autoleucel, a CAR-T cell therapy, for people with severe forms of two autoimmune diseases that cause blood vessel inflammation (GPA and MPA). It will compare this one-time cell therapy to standard treatments to see if it is better at controlling the disease and reducing the need for steroids. The study will enroll about 126 adults with active, severe disease and follow some participants for up to 15 years to monitor long-term safety.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States

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LDS Hospital
RECRUITING

Salt Lake City, Utah, 84143, United States

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Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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Mayo Clinic Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States

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Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States

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Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

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Novartis Investigative Site
RECRUITING

Salvador, Estado de Bahia, 41253-190, Brazil
Novartis Investigative Site
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Barretos, São Paulo, 14784 400, Brazil
Novartis Investigative Site
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São Paulo, São Paulo, 01308-050, Brazil
Novartis Investigative Site
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São Paulo, 01509-010, Brazil
Novartis Investigative Site
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Haifa, 3109601, Israel
Novartis Investigative Site
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Ramat Gan, 5265601, Israel
Novartis Investigative Site
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Sapporo, Hokkaido, 0608648, Japan
Novartis Investigative Site
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Kobe, Hyōgo, 6500047, Japan
Novartis Investigative Site
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Kanazawa, Ishikawa-ken, 920 8641, Japan
Novartis Investigative Site
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Sendai, Miyagi, 9808574, Japan
Novartis Investigative Site
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Suita, Osaka, 5650871, Japan
Novartis Investigative Site
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Bunkyo Ku, Tokyo, 1138431, Japan
Novartis Investigative Site
RECRUITING

Shinjuku-ku, Tokyo, 1608582, Japan
Novartis Investigative Site
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Chiba, 260 8677, Japan
Novartis Investigative Site
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Fukuoka, 8128582, Japan
Novartis Investigative Site
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Kyoto, 6068507, Japan
Novartis Investigative Site
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Riyadh, 11211, Saudi Arabia
Novartis Investigative Site
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Singapore, 119074, Singapore
Novartis Investigative Site
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Singapore, S308433, Singapore
Novartis Investigative Site
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Basel, 4031, Switzerland
Novartis Investigative Site
RECRUITING

Bern, 3010, Switzerland
Novartis Investigative Site
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Novartis Investigative Site
RECRUITING

London, W12 0HS, United Kingdom
Oregon Health Sciences University
RECRUITING

Portland, Oregon, 97239, United States

Contact

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University Of Colorado
RECRUITING

Aurora, Colorado, 80045, United States

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Conditions

Explore the condition pages connected to this study.

ANCA ASSOCIATED VASCULITIS (AAV)