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One-Shot cell therapy aims to reset immune system in Tough-to-Treat lupus

NCT ID NCT06581198

Recruiting now Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

Summary

This study is testing a single infusion of a genetically modified cell therapy called rapcabtagene autoleucel for adults with severe lupus or lupus kidney disease that hasn't responded to at least two standard treatments. The goal is to see if this one-time treatment can put the disease into remission and reduce or eliminate the need for ongoing steroids and other strong medications. Researchers will closely monitor patients for one year to check how well the treatment works and how safe it is.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Ann and Robert H Lurie Childs Hosp

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact Email: •••••@•••••

    Contact

  • Boston Medical Center

    RECRUITING

    Boston, Massachusetts, 02118, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • LDS Hospital

    RECRUITING

    Salt Lake City, Utah, 84143, United States

  • LDS Hospital

    RECRUITING

    Salt Lake City, Utah, 84143, United States

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Loma Linda University

    RECRUITING

    San Bernardino, California, 92408, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

    Contact

    Contact Email: •••••@•••••

  • Novartis Investigative Site

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Novartis Investigative Site

    RECRUITING

    Graz, 8036, Austria

  • Novartis Investigative Site

    RECRUITING

    Vienna, 1090, Austria

  • Novartis Investigative Site

    RECRUITING

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Novartis Investigative Site

    RECRUITING

    Barretos, São Paulo, 14784 400, Brazil

  • Novartis Investigative Site

    RECRUITING

    São Paulo, São Paulo, 01232-010, Brazil

  • Novartis Investigative Site

    RECRUITING

    São Paulo, São Paulo, 01308-050, Brazil

  • Novartis Investigative Site

    RECRUITING

    São Paulo, 01509-010, Brazil

  • Novartis Investigative Site

    RECRUITING

    Olomouc, 779 00, Czechia

  • Novartis Investigative Site

    RECRUITING

    Prague, 128 00, Czechia

  • Novartis Investigative Site

    RECRUITING

    Prague, 128 08, Czechia

  • Novartis Investigative Site

    RECRUITING

    Aarhus N, 8200, Denmark

  • Novartis Investigative Site

    RECRUITING

    Bordeaux, 33076, France

  • Novartis Investigative Site

    RECRUITING

    Marseille, 13005, France

  • Novartis Investigative Site

    RECRUITING

    Nantes, 44093, France

  • Novartis Investigative Site

    RECRUITING

    Paris, 75013, France

  • Novartis Investigative Site

    RECRUITING

    Paris, 75014, France

  • Novartis Investigative Site

    RECRUITING

    Strasbourg, 67091, France

  • Novartis Investigative Site

    RECRUITING

    Toulouse, 31054, France

  • Novartis Investigative Site

    RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Novartis Investigative Site

    RECRUITING

    Stuttgart, Baden-Wurttemberg, 70376, Germany

  • Novartis Investigative Site

    RECRUITING

    Frankfurt am Main, Hesse, 60528, Germany

  • Novartis Investigative Site

    RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Novartis Investigative Site

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Novartis Investigative Site

    RECRUITING

    Jena, Thuringia, 07740, Germany

  • Novartis Investigative Site

    RECRUITING

    Essen, 45147, Germany

  • Novartis Investigative Site

    RECRUITING

    Mainz, 55131, Germany

  • Novartis Investigative Site

    RECRUITING

    Nuremberg, 90419, Germany

  • Novartis Investigative Site

    RECRUITING

    Ulm, 89081, Germany

  • Novartis Investigative Site

    RECRUITING

    Debrecen, Hajdu Bihar Megye, 4032, Hungary

  • Novartis Investigative Site

    RECRUITING

    Budapest, H-1083, Hungary

  • Novartis Investigative Site

    RECRUITING

    Ramat Gan, 5265601, Israel

  • Novartis Investigative Site

    RECRUITING

    Alessandria, AL, 15121, Italy

  • Novartis Investigative Site

    RECRUITING

    Ancona, AN, 60126, Italy

  • Novartis Investigative Site

    RECRUITING

    Genova, GE, 16132, Italy

  • Novartis Investigative Site

    RECRUITING

    Milan, MI, 20122, Italy

  • Novartis Investigative Site

    RECRUITING

    Milan, MI, 20132, Italy

  • Novartis Investigative Site

    RECRUITING

    Rozzano, MI, 20089, Italy

  • Novartis Investigative Site

    RECRUITING

    Pescara, PE, 65124, Italy

  • Novartis Investigative Site

    RECRUITING

    Pisa, PI, 56126, Italy

  • Novartis Investigative Site

    RECRUITING

    Pavia, PV, 27100, Italy

  • Novartis Investigative Site

    RECRUITING

    Sapporo, Hokkaido, 0608648, Japan

  • Novartis Investigative Site

    RECRUITING

    Kobe, Hyōgo, 6500047, Japan

  • Novartis Investigative Site

    RECRUITING

    Kanazawa, Ishikawa-ken, 920 8641, Japan

  • Novartis Investigative Site

    RECRUITING

    Yokohama, Kanagawa-ku, 236-0004, Japan

  • Novartis Investigative Site

    RECRUITING

    Sendai, Miyagi, 9808574, Japan

  • Novartis Investigative Site

    RECRUITING

    Suita, Osaka, 5650871, Japan

  • Novartis Investigative Site

    RECRUITING

    Izumo, Shimane, 693 8501, Japan

  • Novartis Investigative Site

    RECRUITING

    Bunkyo Ku, Tokyo, 1138431, Japan

  • Novartis Investigative Site

    RECRUITING

    Bunkyo-ku, Tokyo, 1138519, Japan

  • Novartis Investigative Site

    RECRUITING

    Chiba, 260 8677, Japan

  • Novartis Investigative Site

    RECRUITING

    Fukuoka, 8128582, Japan

  • Novartis Investigative Site

    RECRUITING

    Kyoto, 6068507, Japan

  • Novartis Investigative Site

    RECRUITING

    Leiden, South Holland, 2333 ZA, Netherlands

  • Novartis Investigative Site

    RECRUITING

    Groningen, 9713 GZ, Netherlands

  • Novartis Investigative Site

    RECRUITING

    Utrecht, 3584 CX, Netherlands

  • Novartis Investigative Site

    RECRUITING

    Oslo, 0372, Norway

  • Novartis Investigative Site

    RECRUITING

    Bucharest, 022328, Romania

  • Novartis Investigative Site

    RECRUITING

    Riyadh, 11211, Saudi Arabia

  • Novartis Investigative Site

    RECRUITING

    Singapore, 119074, Singapore

  • Novartis Investigative Site

    RECRUITING

    Seoul, 06591, South Korea

  • Novartis Investigative Site

    RECRUITING

    Santiago Compostela, A Coruna, 15706, Spain

  • Novartis Investigative Site

    RECRUITING

    Santander, Cantabria, 39008, Spain

  • Novartis Investigative Site

    RECRUITING

    Pamplona, Navarre, 31008, Spain

  • Novartis Investigative Site

    RECRUITING

    Barcelona, 08035, Spain

  • Novartis Investigative Site

    RECRUITING

    Córdoba, 14004, Spain

  • Novartis Investigative Site

    RECRUITING

    Madrid, 28009, Spain

  • Novartis Investigative Site

    RECRUITING

    Madrid, 28041, Spain

  • Novartis Investigative Site

    RECRUITING

    Salamanca, 37007, Spain

  • Novartis Investigative Site

    RECRUITING

    Valencia, 46026, Spain

  • Novartis Investigative Site

    RECRUITING

    Stockholm, 17176, Sweden

  • Novartis Investigative Site

    RECRUITING

    Lausanne, 1011, Switzerland

  • Novartis Investigative Site

    RECRUITING

    Taichung, 407219, Taiwan

  • Novartis Investigative Site

    RECRUITING

    Taipei, 10002, Taiwan

  • Novartis Investigative Site

    RECRUITING

    Sheffield, South Yorkshire, S10 2JF, United Kingdom

  • Novartis Investigative Site

    RECRUITING

    London, W12 0HS, United Kingdom

  • Oregon Health Sciences University

    RECRUITING

    Portland, Oregon, 97239, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sutter Health Network

    RECRUITING

    San Pablo, California, 94806, United States

    Contact Email: •••••@•••••

    Contact

  • Tufts Medical Center

    RECRUITING

    Boston, Massachusetts, 02111, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • UCSF

    RECRUITING

    San Francisco, California, 94115, United States

  • UCSF

    RECRUITING

    San Francisco, California, 94115, United States

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Univ Of TX MD Anderson CC

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Email: •••••@•••••

    Contact

  • University Of Alabama

    RECRUITING

    Birmingham, Alabama, 35294, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • University Of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Kentucky

    RECRUITING

    Lexington, Kentucky, 40536-0284, United States

    Contact Email: •••••@•••••

    Contact

  • University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • WA Uni School Of Med

    RECRUITING

    St Louis, Missouri, 63110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.

LUPUS ERYTHEMATOSUS, SYSTEMIC LUPUS NEPHRITIS