Engineered immune cells take aim at Hard-to-Treat myeloma
NCT ID NCT07541391
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new type of immunotherapy called CAR T-cells, which are made from a patient's own immune cells and engineered to recognize and attack a protein called KMA on myeloma cells. The study will enroll 12 adults with relapsed or refractory multiple myeloma that has not responded to at least two prior treatments. The main goal is to check the safety of these cells and find the best dose, while also looking at how well they work.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CAR T-cells targeting the kappa myeloma antigen (KMA)
- What this could lead to
- If successful, this could provide a new treatment option for patients with relapsed/refractory multiple myeloma who have limited choices.
- What could go wrong
- This is a very early phase 1 trial with only 12 participants, so it is primarily testing safety. The treatment may not work, and there are risks of serious side effects like cytokine release syndrome.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Peter MacCallum Cancer Centre
RECRUITINGMelbourne, Victoria, 3000, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a lower dose of a myeloma drug keep the disease in check with fewer side effects?
- A pre-treatment pill may supercharge cancer-fighting immune cells
- New antibody combo aims to stall multiple Myeloma's return
- Real-World data may reveal best Second-Line therapy for multiple myeloma