New Dual-Targeting CAR T-Cells aim to outsmart tough lymphoma
NCT ID NCT04989803
First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 28 times
Summary
This study is testing two experimental treatments, KITE-363 and KITE-753, for people with B-cell lymphoma that has returned or stopped responding to standard therapy. These are personalized cell therapies made from a patient's own immune cells, engineered to attack two targets (CD19 and CD20) on lymphoma cells. The study will first check safety and find the right dose, then measure how well the treatments shrink tumors. About 247 adults will take part.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Academisch Medisch Centrum
RECRUITINGAmsterdam, 1105 AZ, Netherlands
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Banner MD Anderson Cancer Center
RECRUITINGGilbert, Arizona, 85234, United States
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City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITINGDuarte, California, 91010, United States
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
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Concord Repatriation General Hospital
RECRUITINGSydney, New South Wales, 2139, Australia
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Epworth Healthcare
RECRUITINGEast Melbourne, Victoria, 3002, Australia
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Jewish General Hospital
RECRUITINGMontreal, H3T 1E2, Canada
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King's College Hospital
COMPLETEDLondon, SE5 9RS, United Kingdom
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McGill University Health Center
RECRUITINGMontreal, H4A 0B1, Canada
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Midwestern Regional Medical Center, Inc.City of Hope Chicago
RECRUITINGPark Ridge, Illinois, 60068, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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Northside Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
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Royal North Shore Hospital
RECRUITINGSt Leonards, New South Wales, 2065, Australia
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Stanford Cancer Institute
RECRUITINGStanford, California, 94305, United States
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The Ohio State University Wexner Medical Center - James Cancer Hospital
RECRUITINGColumbus, Ohio, 43210, United States
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The University of Texas, MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Universitatsklinikum Wurzburg
RECRUITINGWürzburg, 97080, Germany
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University of MD, Greenebaum Comprehensive Cancer Center
RECRUITINGBaltimore, Maryland, 21201, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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Virginia Oncology Associates
RECRUITINGNorfolk, Virginia, 23502, United States
Conditions
Explore the condition pages connected to this study.