Scientists test 'Clean-Up' drugs to boost Cancer-Killing power of CAR T-Cell therapy

NCT ID NCT05633615

Recruiting now Disease control Sponsor: SWOG Cancer Research Network Source: ClinicalTrials.gov ↗

Summary

This study is for adults with aggressive B-cell lymphoma that has returned or not responded to prior treatments. After receiving a standard CAR T-cell therapy, patients whose cancer is still present but stable will be assigned to receive one of two additional drugs, both drugs, or no extra treatment. The goal is to see if these 'consolidation' therapies help control the cancer longer and prevent it from growing back.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Atrium Health Cabarrus/LCI-Concord
RECRUITING

Concord, North Carolina, 28025, United States

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Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States

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Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

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Beacon Kalamazoo Cancer Center
RECRUITING

Kalamazoo, Michigan, 49009, United States

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Bronson Battle Creek
RECRUITING

Battle Creek, Michigan, 49017, United States

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Bronson Methodist Hospital
RECRUITING

Kalamazoo, Michigan, 49007, United States

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Cancer and Hematology Centers of Western Michigan - Norton Shores
RECRUITING

Norton Shores, Michigan, 49444, United States

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Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States

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Case Western Reserve University
RECRUITING

Cleveland, Ohio, 44106, United States

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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
RECRUITING

Saint Joseph, Michigan, 49085, United States

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Corewell Health Lakeland Hospitals - Niles Hospital
RECRUITING

Niles, Michigan, 49120, United States

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Corewell Health Reed City Hospital
RECRUITING

Reed City, Michigan, 49677, United States

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Dartmouth Cancer Center - North
RECRUITING

Saint Johnsbury, Vermont, 05819, United States

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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States

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Duke University Medical Center
SUSPENDED

Durham, North Carolina, 27710, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States

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Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States

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Froedtert and MCW Moorland Reserve Health Center
RECRUITING

New Berlin, Wisconsin, 53151, United States

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Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

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Henry Ford Health Providence Southfield Hospital
ACTIVE_NOT_RECRUITING

Southfield, Michigan, 48075, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

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Highlands Oncology Group
RECRUITING

Springdale, Arkansas, 72762, United States

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Highlands Oncology Group - Fayetteville
RECRUITING

Fayetteville, Arkansas, 72703, United States

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Highlands Oncology Group - Rogers
RECRUITING

Rogers, Arkansas, 72758, United States

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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States

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Loyola University Medical Center
SUSPENDED

Maywood, Illinois, 60153, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States

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Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States

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Munson Medical Center
RECRUITING

Traverse City, Michigan, 49684, United States

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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

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NYP/Weill Cornell Medical Center
SUSPENDED

New York, New York, 10065, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

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Prisma Health Cancer Institute - Butternut
RECRUITING

Greenville, South Carolina, 29605, United States

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Prisma Health Cancer Institute - Easley
RECRUITING

Easley, South Carolina, 29640, United States

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Prisma Health Cancer Institute - Eastside
RECRUITING

Greenville, South Carolina, 29615, United States

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Prisma Health Cancer Institute - Faris
RECRUITING

Greenville, South Carolina, 29605, United States

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Prisma Health Cancer Institute - Greer
RECRUITING

Greer, South Carolina, 29650, United States

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Prisma Health Cancer Institute - Seneca
RECRUITING

Seneca, South Carolina, 29672, United States

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Prisma Health Cancer Institute - Spartanburg
RECRUITING

Boiling Springs, South Carolina, 29316, United States

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Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

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Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

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Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

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Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

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Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States

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Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States

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Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States

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Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States

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Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States

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Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Sanford Roger Maris Cancer Center
RECRUITING

Fargo, North Dakota, 58122, United States

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Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States

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The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States

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Trinity Health Grand Rapids Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States

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Trinity Health Muskegon Hospital
RECRUITING

Muskegon, Michigan, 49444, United States

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UC Irvine Health Cancer Center-Newport
RECRUITING

Costa Mesa, California, 92627, United States

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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

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UCI Health Laguna Hills
RECRUITING

Laguna Hills, California, 92653, United States

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UCSF Medical Center-Parnassus
RECRUITING

San Francisco, California, 94143, United States

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UF Health Cancer Institute - Gainesville
RECRUITING

Gainesville, Florida, 32610, United States

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University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States

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University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States

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University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

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University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States

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University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States

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University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States

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University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States

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University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States

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University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

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University of Michigan Health - West
RECRUITING

Wyoming, Michigan, 49519, United States

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University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

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University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States

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University of Pennsylvania/Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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University of Rochester
RECRUITING

Rochester, New York, 14642, United States

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University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States

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University of Vermont and State Agricultural College
RECRUITING

Burlington, Vermont, 05405, United States

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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

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UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

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VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States

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Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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Wayne State University/Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States

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Weisberg Cancer Treatment Center
RECRUITING

Farmington Hills, Michigan, 48334, United States

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West Michigan Cancer Center
RECRUITING

Kalamazoo, Michigan, 49007, United States

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Wilmot Cancer Institute at Webster
RECRUITING

Webster, New York, 14580, United States

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Conditions

Explore the condition pages connected to this study.

DIFFUSE LARGE B CELL LYMPHOMA GRADE 3B FOLLICULAR LYMPHOMA PRIMARY MEDIASTINAL (THYMIC) LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA TRANSFORMED FOLLIC LYMPH TO DIFF LARGE B-CELL LYMPHOMA TRANSFORMED MARG ZONE LYMPH TO DIFF LARGE B-CELL LYMPHOMA