New study to track brain health after CAR-T cancer treatment

NCT ID NCT07463781

Not yet recruiting Knowledge-focused Sponsor: Fondazione Italiana Linfomi - ETS Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study follows 100 adults with certain types of lymphoma who are receiving CAR-T cell therapy. Researchers will test memory, attention, and other thinking skills before treatment and at 6, 12, and 24 months after. The goal is to learn how CAR-T therapy affects brain function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CAR-T cell therapy
What this could lead to: If successful, this could help doctors better understand and manage memory and thinking problems that may occur after CAR-T therapy.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly improve outcomes. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma high grade B-cell lymphoma primary mediastinal large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIFFUSE-LARGE B-CELL LYMPHOMA (DLBCL) HIGH-GRADE B-CELL LYMPHOMA PRIMARY MEDIASTINAL B-CELL LYMPHOMA (PMBCL)

Contacts and locations

Locations

Clinica di Ematologia, AOU Ospedali Riuniti

Ancona, Italy
Divisione di Ematologia - A.O. Ospedali Riuniti Villa Sofia-Cervello

Palermo, Italy
Ematologia - Grande Ospedale Metropolitano Bianchi Melacrino Morelli

Reggio Calabria, Italy
Ematologia - Università Cattolica S. Cuore

Roma, Italy
SC Ematologia - Ospedale "S.G. Moscati"

Taranto, Italy
SCDU Ematologia - AOU SS. Antonio e Biagio e Cesare Arrigo di Alessandria

Alessandria, Italy
SOC Clinica Ematologica - Azienda Sanitaria Universitaria Friuli Centrale (ASU FC)

Udine, Italy
USD-TMO Adulti - ASST Spedali Civili di Brescia

Brescia, Italy

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