Supercharged immune cells take on pancreatic cancer in new trial
NCT ID NCT07480928
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new type of immunotherapy for people with advanced pancreatic cancer that has spread or cannot be removed. The treatment uses specially engineered natural killer (NK) cells that target two cancer-related proteins at once. Up to 42 participants will receive these cells along with chemotherapy to prepare the body, and researchers will monitor safety and whether tumors shrink.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Dual-targeting CAR-NK cells (engineered immune cells) targeting MSLN and MUC1 or CLDN18.2 and MUC1, plus lymphodepleting chemotherapy
- What this could lead to
- If successful, this could point toward a new treatment option for advanced pancreatic cancer that is hard to treat with current therapies.
- What could go wrong
- This is an early phase 1/2 trial with only 42 participants, so results may not apply broadly. CAR-NK therapy can cause serious side effects like cytokine release syndrome or organ damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Peking University Shenzhen Hospital
RECRUITINGShenzhen, Guangdong, 518036, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Scientists hunt for biomarkers to catch pancreatic cancer before it strikes
- New PET tracer aims to spot hidden cancer spread in the abdomen
- Experimental drug inavolisib targets Hard-to-Treat pancreatic cancer
- Mini-Tumors in a dish may guide pancreatic cancer treatment
- New drug cocktail aims to tackle tough pancreatic cancer