Race for better fungal infection treatment halted early

NCT ID NCT05178862

Terminated Disease control Sponsor: Scynexis, Inc. Source: ClinicalTrials.gov ↗

Summary

This study aimed to compare two different oral antifungal treatments for patients with serious Candida bloodstream or tissue infections. After receiving initial intravenous treatment, participants were randomly assigned to receive either oral ibrexafungerp or oral fluconazole. The trial was designed to see which treatment combination worked better but was terminated before completion.

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Contacts and locations

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Locations

Augusta University Medical Center

Augusta, Georgia, 30912, United States
Banner University Medical Center-Tucson

Tucson, Arizona, 85719, United States
Big Metropolitan Hospital Niguarda Regional Health Authority

Milan, 20162, Italy
CHA Bundang Medical Center, CHA University

Gyeonggi-do, South Korea
Central Friuli University Healthcare Company

Udine, Italy
Chaim Sheba Medical Center

Tel Litwinsky, Israel
Chinese Academy of Medical Sciences

Jinghai, Tianjin Municipality, 301617, China
Duke University

Durham, North Carolina, 27710, United States
FCRN Clinical Trials Centre

Vereeniging, Gauteng, 1935, South Africa
Frankfurt University Clinic

Frankfurt, 60596, Germany
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Gangnam Severance Hospital

Seoul, South Korea
General Hospital of Athens "Evangelismos"

Athens, Greece
General Hospital of Athens "Evangelismos", 1st Department of Critical Care

Athens, Greece
General Hospital of Thessaloniki "Ippokratio"

Thessaloniki, Greece
General University Hospital Gregorio Maranon

Madrid, Spain
Hainan General Hospital

Haikou, Hainan, 572000, China
Helios Clinic Wuppertal

Wuppertal, Germany
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hospital Clínic de Barcelona

Barcelona, Catalonia, 08036, Spain
Hospital del Mar Medical Research Institute (IMIM)

Barcelona, Catalonia, Spain
Houston Methodist Hospital

Houston, Texas, 77030, United States
Huashan Hospital, Institute of Antibiotics

Shanghai, Shanghai Municipality, 200040, China
IRCCS- University Hospital San Martino-IST

Genoa, Liguria, 16132, Italy
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Keimyung University - Dongsan Medical Center

Daegu, South Korea
LAIKO General Hospital

Athens, Greece
LSU Health Sciences Center

Shreveport, Louisiana, 71103, United States
Lady Davis Carmel Medical Center, Infectious Diseases Unit

Haifa, Israel
Lakeview Hospital

Benoni, Gauteng, 1500, South Africa
Life Groenkloof Hospital

Pretoria, Gauteng, 0181, South Africa
Lishui People's Hospital

Lishui, Zhejiang, 323000, China
Liuzhou People's Hospital

Liuchow, Liuzhou, 530021, China
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
Mediclinic Victoria

Tongaat, KwaZulu-Natal, 4400, South Africa
Mercury Street Medical Group, PLLC

Butte, Montana, 59701, United States
Municipal Hospital Munich GMbH/Hospital Neuperlach

Munich, Germany
Nanfang Hospital of Southern Medical University

Guangdong, Guangzhou, 510420, China
Nantes University Hospital Center

Nantes, 44093, France
Netcare Jakaranda Hospital

Pretoria, Gauteng, 0002, South Africa
Ochsner Medical Center

New Orleans, Louisiana, 70121, United States
Paris University Hospitals Center- Cochin Hospital

Paris, France
Princess Margaret Hospital

Toronto, Ontario, Canada
Qingyuan People's Hospital

Qingyuan, Guangdong, 511518, China
Rambam Health Care Campus, Institute of Infectious Diseases

Haifa, Israel
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Ruijin Hospital

Shanghai, Shanghai Municipality, 200025, China
Saint Luc University Hospital

Brussels, Belgium
Saint-Louis Hospital

Paris, France
Severance Hospital, Yonsei University Health System

Seoul, South Korea
Shanghai 10th People's Hospital

Shanghai, Shanghai Municipality, 200072, China
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The First Affiliated Hospital of Chongqing Medical University

Chongqing, Yuzhong, 400042, China
The First Affiliated Hospital of Guangzhou Medical University

Guandong, Guangzhou, 510230, China
The First Affiliated Hospital of Jinan University

Guandong, Guangzhou, 510630, China
The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510080, China
The First Hospital of Kunming

Kunming, Yunnan, 650034, China
The Miriam Hospital

Providence, Rhode Island, 02906, United States
The Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel
The Third Affiliated Hospital Of Sun Yat-Sen University (ZSSY)

Guangdong, Guangzhou, 510630, China
The first affiliated hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310003, China
Tianjin Medical University General Hospital

Xiaobailou, Tianjin Municipality, 300052, China
UC Davis Medical Center

Sacramento, California, 95817, United States
UCSF School of Medicine

San Francisco, California, 94143, United States
Univeristy Hospital Jena

Jena, Thuringia, Germany
University Clinical Hospital of Valencia

Valencia, Spain
University General Hospital "Attikon"

Athens, Greece
University Health Network- Toronto General Hospital

Toronto, Ontario, Canada
University Hospital Center of Poitiers

Poitiers, France
University Hospital Cologne

Cologne, 50937, Germany
University Hospital Freiburg

Freiburg im Breisgau, Baden-Wurttemberg, Germany
University Hospital Ghent

Ghent, Belgium
University Hospital Puerta de Hierro Majadahonda

Madrid, Spain
University Hospital Ramon y Cajal

Madrid, 28034, Spain
University Hospital Virgen Macarena

Seville, Andalusia, Spain
University Hospital de La Princesa

Madrid, Spain
University Hospitals Leuven, Campus Gasthuisberg

Leuven, Belgium
University Multiprofile Hospital for Active Treatment "Eurohospital Plovdiv", Plovdiv, Department of Surgery

Plovdiv, Bulgaria
University Multiprofile Hospital for Active Treatment "Prof. Dr. Stoyan Kirkovich"

Stara Zagora, Bulgaria
University Multiprofile Hospital for Active Treatment and Emergency Medicine "N.I. Pirogov", Sofia, Clinic of Purulent-Septic Surgery

Sofia, Bulgaria
University Polyclinic Hospital of Modena

Modena, 41124, Italy
University and Polytechnic Hospital La Fe

Valencia, Spain
University of Alabama at Birmingham School of Medicine

Birmingham, Alabama, 70121, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Colorado Anschutz Medical Campus

Denver, Colorado, 80291, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Michigan Hospital

Ann Arbor, Michigan, 48109, United States
University of Minnesota Medical Center

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania School of Medicine

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15260, United States
University of Pretoria and Steve Biko Academic Hospital

Pretoria, South Africa
University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Victor Dupouy Hospital Center Argenteuil

Argenteuil, 95107, France
Washington University School of Medicine

St Louis, Missouri, 63110, United States
West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China
Wonju Severance Christian Hospital

Wŏnju, South Korea
Xiangya Hospital, Central South University

Changsha, Hunan, 410008, China
Zhejiang Provincal Hospital of Chinese Medicine

Hangzhou, Zhejiang, 310006, China
Zuid-Afrikaans Hospital

Pretoria, Gauteng, 0002, South Africa

Conditions

Explore the condition pages connected to this study.

CANDIDEMIA CANDIDIASIS, INVASIVE