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Can a daily capsule keep knees happy? a supplement blend puts joint health to the test

NCT ID NCT07729657

Symptom relief Sponsor: Bloomage Biotechnology Corp., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time

Summary

This trial is testing whether a dietary supplement containing N-acetylglucosamine (NAG), hyaluronic acid (HA), and pyrroloquinoline quinone (PQQ) can reduce knee pain and improve physical function in healthy Japanese adults with low muscle mass and mild knee discomfort. Participants take three capsules daily for 12 weeks and complete questionnaires, strength tests, and walking assessments. Researchers compare the supplement blend against a placebo to see if it truly helps.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a dietary supplement containing N-acetylglucosamine (NAG), hyaluronic acid (HA), and pyrroloquinoline quinone (PQQ)
What this could lead to
If the supplements prove effective, they could offer a simple, non-drug option for supporting joint health and mobility in people with early knee discomfort.
What could go wrong
This is an early-stage trial with a small number of participants. The supplements may show no meaningful benefit over placebo, and individual results may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Japanese 2. Men or women 3. Adults 4. Healthy individuals 5. Individuals whose body mass index is ≥18.5 and \<30 kg/m2 6. Individuals who have low whole-body muscle mass 7. Individuals with KL grades of 0 or I on radiographic examination 8. Individuals with high knee pain intensity using the JKOM, as measured by VAS Exclusion Criteria: 1. Individuals receiving treatment for or have a history of malignant tumors, heart failure, or myocardial infarction 2. Individuals with an implanted pacemaker or implantable cardioverter-defibrillator 3. Individuals undergoing treatment for any of the following chronic diseases: cardiac arrhythmia, liver disorder, chronic kidney disease, cerebrovascular disorder, rheumatic disease, diabetes mellitus, dyslipidemia, hypertension, or any other chronic diseases 4. Individuals consuming Foods for Specified Health Uses (FOSHU) or FFC 5. Individuals taking or using medications (including herbal medicines) or supplements 6. Individuals who are allergic to medications or foods related to the test product 7. Individuals engaging at least 60 minutes per week in physical activity that induces heavy breathing and sweating 8. Individuals engaging in strength training (including bodyweight exercises such as push-ups), running, walking, cycling, or swimming at least twice a week 9. Individuals who are pregnant, lactating, or planning to become pregnant during the study period 10. Individuals usually taking FOSHU or FFC, e.g., NAG, proteoglycan from salmon nasal cartilage (SNC), undenatured type II collagen from SNC, glucosamine hydrochloride, curcumin, elastin peptide from skipjack, or collagen peptide 11. Individuals engaging in intense knee joint-loading exercise (e.g., ball sports, such as soccer, baseball, and basketball, jogging, running, skiing, or snowboarding) 12. Individuals who use a cane or joint support, or may use them during this study 13. Individuals deemed unsuitable to participate in this study by the principal investigator

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy japanese individuals

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical Corporation Seishinkai, Takara Clinic

    Shinagawa-ku, Tokyo, 141-0022, Japan

  • Nerima Medical Association Minami-machi Clinic

    Nerima-ku, Tokyo, 176-0002, Japan