Could a simple calcium injection prevent dangerous bleeding in C-Sections?

NCT ID NCT06235749

Disease control Sponsor: Rambam Health Care Campus Source: ClinicalTrials.gov ↗

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial investigates whether giving calcium gluconate intravenously after umbilical cord clamping can reduce blood loss during elective cesarean deliveries. Calcium is essential for blood clotting and uterine muscle contraction, and low calcium levels are linked to heavier bleeding. The study will compare hemoglobin drop and bleeding complications between women who receive calcium gluconate and those who receive a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: calcium gluconate 10% solution given intravenously after umbilical cord clamping
What this could lead to: If effective, this simple, low-cost intervention could become a standard preventive measure to reduce dangerous bleeding during cesarean deliveries.
What could go wrong: This is a single-center trial, and calcium's effect on bleeding in this setting is not yet proven. The benefit may be small or absent, and rare side effects like hypercalcemia or arrhythmia are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Elective Cesarean Delivery, at Gestational age of 35 weeks or more. Exclusion Criteria: * Age younger than 18 years old. * Patients treated with calcium channel blockers. * Chronic renal failure and hyperphosphatemia. * Sarcoidosis. * Hypocalcemia (ionized Ca\<1 mmol/L) or hypercalcemia (ionized Ca\> 1.3 mmol/L) before the surgery. * Any QT abnormalities as evident by ECG before Calcium Gluconate administrations or any known conduction abnormality.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Elective cesarean delivery are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Elective cesarean delivery

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

4 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a simple calcium injection prevent dangerous bleeding in C-Sections?

What the study statuses mean