Gene test could reveal if caffeine boosts your gym performance
NCT ID NCT06610110
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a gene called CYP1A2 affects the way caffeine influences strength and power during weightlifting. Sixty healthy, active adults took either caffeine or a placebo before exercise. Researchers measured things like bar speed, power output, and how many reps they could do. The goal was to see if genetic differences explain why some people get a bigger boost from caffeine than others.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- caffeine
- What this could lead to
- If successful, this could help personalize caffeine use for better workout performance based on a person's genetics.
- What could go wrong
- This is a small, completed study focused on acute effects, not a treatment. Results may not apply to everyone or lead to practical changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
60 people
The number who actually took part.
- Started
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Apr 2024
- Finished
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Jul 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between ≥ 18 and ≤ 35 years. * Body mass index (BMI) lower than 25 kg/m². * Physically active subjects (≥150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests. Exclusion Criteria: * History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. * Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
Alcalá de Henares, Madrid, 28805, Spain
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Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá
Alcalá de Henares, Madrid, Spain
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