Promising combo for advanced melanoma studied, but trial halted early

NCT ID NCT03957551

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 24 times

Summary

This early-phase trial tested a combination of two drugs, cabozantinib and pembrolizumab, as a first treatment for people with advanced melanoma that had spread. The goal was to see if the combination was safe and could shrink tumors. The study was stopped early, but it enrolled 28 participants to gather initial safety and effectiveness data.

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Contacts and locations

Locations

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

Conditions

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