New drug cocktail aims to stall Hard-to-Treat gut tumors

NCT ID NCT05048901

Recruiting now Disease control Sponsor: National Health Research Institutes, Taiwan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a combination of two drugs—cabozantinib (a daily pill) and lanreotide (a monthly injection)—in people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that have stopped responding to prior treatments. The trial has two phases: the first finds the safest dose, and the second measures how long the cancer stays under control. About 49 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cabozantinib and lanreotide
What this could lead to: If successful, this combination could offer a new treatment option for people with advanced GEP-NET whose cancer has stopped responding to other targeted therapies or chemotherapy.
What could go wrong: This is an early-phase trial with only 49 participants, so results may not apply to all patients. The combination may cause significant side effects, and it is not yet known if it will improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for NEUROENDOCRINE TUMORS,GASTROENTEROPANCREATIC are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine tumor, grade 1/2 neuroendocrine neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROENDOCRINE TUMORS,GASTROENTEROPANCREATIC

Contacts and locations

Locations

Chang Gung Medical Foundation
RECRUITING

Kaohsiung City, Taiwan
Chang Gung Medical Foundation
RECRUITING

Taoyuan, Taiwan
Changhua Christian Hospital
RECRUITING

Changhua, Taiwan
China Medical University Hospital
RECRUITING

Taichung, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung City, Taiwan
Mackay Memorial Hospital
RECRUITING

Taipei, Taiwan
National Cheng Kung University Hospita
RECRUITING

Tainan, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan
Taichung Veterans General Hospital
RECRUITING

Taichung, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, Taiwan
Tri-Service General Hospital
RECRUITING

Taipei, Taiwan