New drug cocktail aims to stall Hard-to-Treat gut tumors

NCT ID NCT05048901

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a combination of two drugs—cabozantinib (a daily pill) and lanreotide (a monthly injection)—in people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) that have stopped responding to prior treatments. The trial has two phases: the first finds the safest dose, and the second measures how long the cancer stays under control. About 49 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cabozantinib and lanreotide

What this could lead to

If successful, this combination could offer a new treatment option for people with advanced GEP-NET whose cancer has stopped responding to other targeted therapies or chemotherapy.

What could go wrong

This is an early-phase trial with only 49 participants, so results may not apply to all patients. The combination may cause significant side effects, and it is not yet known if it will improve survival.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

digestive system neuroendocrine tumor, grade 1/2 neuroendocrine neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Chang Gung Medical Foundation

    RECRUITING

    Kaohsiung City, Taiwan

    Contact

  • Chang Gung Medical Foundation

    RECRUITING

    Taoyuan, Taiwan

    Contact

  • Changhua Christian Hospital

    RECRUITING

    Changhua, Taiwan

    Contact

  • China Medical University Hospital

    RECRUITING

    Taichung, Taiwan

    Contact

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, Taiwan

    Contact

  • Mackay Memorial Hospital

    RECRUITING

    Taipei, Taiwan

    Contact

  • National Cheng Kung University Hospita

    RECRUITING

    Tainan, Taiwan

    Contact

  • National Taiwan University Hospital

    RECRUITING

    Taipei, Taiwan

    Contact

    Contact

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, Taiwan

    Contact

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, Taiwan

    Contact

  • Tri-Service General Hospital

    RECRUITING

    Taipei, Taiwan

    Contact