New pill combo shows promise for tough brain cancer

NCT ID NCT03328078

Recruiting now Disease control Sponsor: Curis, Inc. Source: ClinicalTrials.gov ↗

First seen Apr 25, 2026 · Last updated May 15, 2026 · Updated 4 times

Summary

This study tests an experimental oral drug called emavusertib (CA-4948), taken alone or with another drug (ibrutinib), in adults with a rare brain lymphoma that has returned or not responded to prior therapy. The goal is to find safe doses and see if the combination can shrink tumors. About 152 participants will take part across multiple centers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center
WITHDRAWN

New York, New York, 10032, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center, Duke Cancer Center
RECRUITING

Durham, North Carolina, 27710, United States
Fred and Pamela Buffett Cancer Center
RECRUITING

Omaha, Nebraska, 68198, United States
Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Hadassah Medical Center / Ein-Carem
RECRUITING

Jerusalem, Israel
Hematology Department Soroka UMC / Heanatology Department
RECRUITING

Beersheba, Israel
Hopital de la Timone
RECRUITING

Marseille, France
Hospital Pitie Salpetriere
RECRUITING

Paris, France
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Spain
Hospital of the University of Pennsylvania
COMPLETED

Philadelphia, Pennsylvania, 19104, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
IRCCS San Raffaele Scientific Institute
RECRUITING

Milan, Italy
IRST - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
RECRUITING

Meldola, Italy
Institut Bergonie
RECRUITING

Bordeaux, France
Institut Curie Hospital
RECRUITING

Paris, France
MD Anderson Cancer Center Madrid
RECRUITING

Madrid, Spain
Mayo Clinic
COMPLETED

Phoenix, Arizona, 85054, United States
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mt Sinai
RECRUITING

New York, New York, 10029, United States
NarodowyInstytutu Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytutu Badawczy
RECRUITING

Warsaw, Poland
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States
Oddzial Kliniczny Hematologii
WITHDRAWN

Krakow, Poland
Providence Neurological Specialties West
RECRUITING

Portland, Oregon, 97225, United States
Providence St. John's Health Center
RECRUITING

Santa Monica, California, 90404, United States
Rambam Medical Center
RECRUITING

Haifa, Israel
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14263, United States
SODc Ematologia Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Italy
Smilow Cancer Hospital at Yale-New Haven
COMPLETED

New Haven, Connecticut, 06510, United States
St. Joseph's Hospital and Medical Center
RECRUITING

Phoenix, Arizona, 85013, United States
Swedish Cancer Institute
COMPLETED

Seattle, Washington, 98104, United States
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UCLA Department of Medicine - Hematology/Oncology
WITHDRAWN

Santa Monica, California, 90404, United States
UPMC Hilman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75235, United States
University Hospital Vall d'Hebron
RECRUITING

Barcelona, Spain
University of Tennessee Medical Center
COMPLETED

Knoxville, Tennessee, 37920, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Università di Torino Croce e Carle
RECRUITING

Cuneo, Italy
Uniwersyteckie Centrum Kliniczne Osrodek Badan Klinicznych Wczesnych Faz
RECRUITING

Gdansk, Poland
Všeobecná fakultní nemocnice v Praze
RECRUITING

Prague, Czechia

Conditions

Explore the condition pages connected to this study.

REFRACTORY HEMATOLOGIC MALIGNANCY REFRACTORY PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA RELAPSED HEMATOLOGIC MALIGNANCY RELAPSED HEMATOLOGIC MALIGNANCY RELAPSED PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA