New drug candidate takes on tough lymphoma in first human tests
NCT ID NCT05737628
First seen Jan 20, 2026 · Last updated May 05, 2026 · Updated 17 times
Summary
This study is the first time the drug BYON4228 is being tested in humans. It is for people with a type of blood cancer called B-cell non-Hodgkin lymphoma that has come back or not responded to at least two prior treatments. The study will test the drug alone and combined with another drug (rituximab) to find safe doses and see if it can shrink tumors. Only 17 participants are enrolled in this early-phase trial.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ASST Spedali Civili di Brescia
Brescia, Italy
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Centro Integral Oncológico Clara Campal (CIOCC) Hospital Universitario HM Sanchinarro
Madrid, Spain
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Hospital Universitari Vall d'Hebron
Barcelona, Spain
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IRCCS Ospedale San Raffaele
Milan, Italy
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Institut Català d'Oncologia
Barcelona, Spain
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Instituto Europeo di Oncologia
Milan, Italy
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Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRCCS IRST
Ravenna, Italy
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Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia - IRCCS
Candiolo, Italy
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Radboud UMC
Nijmegen, Netherlands
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The Christie NHS Foundation Trust
Manchester, United Kingdom
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University Hospitals Plymouth NHS Trust
Plymouth, United Kingdom
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Vrije Universiteit Medisch Centrum
Amsterdam, Netherlands
Conditions
Explore the condition pages connected to this study.