New hope for tiniest babies: drug combo aims to prevent devastating lung disease
NCT ID NCT04545866
First seen Nov 11, 2025 · Last updated Apr 20, 2026 · Updated 17 times
Summary
This large Phase 3 trial is testing whether adding a steroid medication called budesonide to the standard lung treatment (surfactant) can help extremely premature babies. The goal is to reduce the combined risk of developing a serious chronic lung disease (Bronchopulmonary Dysplasia) or dying by 36 weeks of age. Over 600 infants born between 22 and 28 weeks will be randomly assigned to receive either the budesonide-surfactant combination or surfactant alone soon after birth.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Brown University - Women and Infants Hospital of Rhode Island
Providence, Rhode Island, 02905, United States
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Case Western Reserve University, Rainbow Babies and Children's Hospital
Cleveland, Ohio, 44106, United States
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Cincinnati Children's Medical Center
Cincinnati, Ohio, 45267, United States
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Duke University
Durham, North Carolina, 27710, United States
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Emory University
Atlanta, Georgia, 30303, United States
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Northwestern Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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RTI International
Durham, North Carolina, 27705, United States
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Research Institute at Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Sharp Mary Birch Hospital for Women & Newborns
San Diego, California, 92123, United States
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Stanford University
Palo Alto, California, 94304, United States
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University of Alabama
Birmingham, Alabama, 35249-7335, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Mississippi Medical Center - Children's of Mississippi
Jackson, Mississippi, 39216, United States
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University of New Mexico
Albuquerque, New Mexico, 87131, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
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University of Rochester
Rochester, New York, 14642, United States
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University of Texas Health Science Center at Houston
Houston, Texas, 77030, United States
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University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, 75235, United States
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University of Utah
Salt Lake City, Utah, 84108, United States
Conditions
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