Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a cheek graft rebuild a damaged ureter?

NCT ID NCT07797829

Disease control Sponsor: Mohamed Salah Abdul Mawgoud Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 04, 2026 · Updated 3 times

Summary

This trial tests a surgical technique that uses a tissue graft from the inside of the cheek to repair long strictures, or narrowings, in the upper or middle part of the ureter, the tube that carries urine from the kidney to the bladder. The procedure aims to widen the narrowed area and restore normal urine flow without the need for more invasive surgeries like ileum replacement or kidney re-implantation. Researchers will enroll 25 adults with strictures longer than 2 centimeters and track whether the repair stays open without requiring another procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Buccal mucosal graft ureteroplasty, a surgical procedure that uses a tissue graft from the inside of the cheek to widen a narrowed ureter.
What this could lead to
If successful, this technique could offer a less invasive alternative to major surgery for people with long ureter strictures, potentially reducing recovery time and complications.
What could go wrong
This is an early-phase study with only 25 participants, so results may not apply to everyone. The surgery carries standard risks like infection, bleeding, or the stricture returning.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (age ≥ 18 years) of either sex. * Confirmed diagnosis of long (\>2 cm) upper and middle ureteric strictures, either fresh or recurrent with previous open or endoscopic intervention. Exclusion Criteria: * Malignant ureteric stricture or stricture secondary to active pelvic/retroperitoneal malignancy. * Active urinary tract infection at the time of planned surgery. * Uncorrected coagulopathy or other contraindication to anesthesia/surgery. * Active oral mucosal disease, oral submucous fibrosis or previous bilateral grafting. * Solitary non-functioning kidney on the affected side with differential renal function\<15% on renogram (relative or absolute non-functioning renal unit) unless reconstruction is otherwise indicated. * Pregnancy. * Cases of ureteric avulsion where ileal ureter substitution will be used or cases with complete ureter obliteration no passing guidewire or ureteric catheter.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Ureter stricture are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

stricture or kinking of ureter

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ureter stricture

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.