New drug shows promise in reducing dangerous lung infections

NCT ID NCT04594369

Completed Disease control Sponsor: Insmed Incorporated Source: ClinicalTrials.gov ↗

Summary

This large Phase 3 trial tested whether a daily pill called brensocatib could reduce the frequency of serious lung flare-ups in people with bronchiectasis, a chronic lung condition. Over 1,700 participants took either the drug or a placebo for one year to see if it lowered their rate of pulmonary exacerbations. The study aimed to provide better disease control for patients who experience recurrent infections and breathing problems.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

ARG001

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1425AZB, Argentina
ARG002

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1414AIF, Argentina
ARG003

Ciudad Autónoma de BuenosAires, Buenos Aires, C1425BEN, Argentina
ARG004

Ciudad Autónoma de BuenosAires, Buenos Aires, C1426ABP, Argentina
ARG005

Córdoba, X5003DCE, Argentina
ARG006

La Plata, Buenos Aires, B1902COS, Argentina
ARG007

Mendoza, M5500CCG, Argentina
ARG009

Villa Vatteone, Buenos Aires, B1853AIK, Argentina
ARG010

Rosario, Santa Fe Province, S2000DTC, Argentina
ARG011

Rosario, S2000JKR, Argentina
ARG012

Buenos Aires, Ciudad Autónoma de BuenosAires, C10227AAP, Argentina
ARG013

Mar del Plata, Buenos Aires, B7600FYK, Argentina
ARG014

Vistalba, Mendoza Province, M5544, Argentina
ARG015

San Miguel de Tucumán, Tucumán Province, T4000IFL, Argentina
ARG017

Mar del Plata, Buenos Aires, CP 7600, Argentina
ARG018

Buenos Aires, Ciudad Autónoma de BuenosAires, C1060, Argentina
ARG019

Santa Fe, 3000, Argentina
ARG021

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1121ABE, Argentina
ARG022

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1122AAK, Argentina
ARG023

Río Cuarto, Córdoba Province, 5800, Argentina
ARG025

San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina
ARG026

Recoleta, Ciudad Autónoma de BuenosAires, C1425EFD, Argentina
ARG027

Bahía Blanca, Buenos Aires, 8000, Argentina
AUS001

Chermside, Queensland, 4032, Australia
AUS002

Box Hill, Victoria, 3128, Australia
AUS003

Concord, NSW 2139, Australia
AUS005

Nedlands, Western Australia, 6009, Australia
AUS006

South Brisbane, Queensland, 4101, Australia
AUS007

Westmead, New South Wales, 2145, Australia
AUS008

New Lambton Heights, New South Wales, 2305, Australia
AUS009

Woodville South, South Australia, 5011, Australia
AUS010

Greenslopes, Queensland, 4120, Australia
AUS011

Adelaide, South Australia, 5000, Australia
AUS012

Cairns North, Queensland, 4870, Australia
AUS013

Kogarah, New South Wales, 2217, Australia
AUS014

Clayton, Victoria, 3168, Australia
AUS015

Spearwood, 6163, Australia
AUS017

Bedford Park, South Australia, 5042, Australia
AUS018

Murdoch, Western Australia, 6150, Australia
AUS019

South Brisbane, Queensland, 4101, Australia
AUS022

North Adelaide, South Australia, 5006, Australia
AUT002

Linz, 4021, Austria
BEL001

Leuven, 3000, Belgium
BEL002

Ghent, Oost-Vlaanderen, 9000, Belgium
BEL003

Mechelen, 2800, Belgium
BEL004

Roeselare, West-Vlaanderen, 8800, Belgium
BEL007

Liège, 4000, Belgium
BEL008

Sint-Niklaas, 9100, Belgium
BEL009

Ghent, Oost-Vlaanderen, 9000, Belgium
BGR002

Sofia, Sofia-Grad, 1680, Bulgaria
BGR004

Plovdiv, 4023, Bulgaria
BGR005

Blagoevgrad, 2700, Bulgaria
BGR006

Gabrovo, 5300, Bulgaria
BGR007

Montana, 3400, Bulgaria
BGR008

Rousse, 7002, Bulgaria
BGR009

Sofia, Sofia-Grad, 1510, Bulgaria
BGR010

Sofia, 1233, Bulgaria
BGR011

Sofia, Sofia-Grad, 1336, Bulgaria
BGR012

Veliko Tarnovo, 5000, Bulgaria
BGR013

Vidin, 3700, Bulgaria
BGR014

Kozloduy, 3320, Bulgaria
BGR015

Lovech, 5500, Bulgaria
BGR016

Vratsa, 3000, Bulgaria
BGR017

Sliven, 8800, Bulgaria
BGR018

Pazardzhik, 4400, Bulgaria
BGR019

Pleven, 5800, Bulgaria
BRA001

Blumenau, Santa Catarina, 89030-240, Brazil
BRA003

Botucatu, 18618-686, Brazil
BRA004

São Bernardo do Campo, 09715-090, Brazil
BRA005

Porto Alegre, Rio Grande do Sul, 90035-074, Brazil
BRA006

Santo André, São Paulo, 09090-790, Brazil
BRA009

Passo Fundo, Rio Grande do Sul, 99010-120, Brazil
BRA011

São Paulo, 05403-000, Brazil
CAN002

Montreal, Quebec, H2X 0A9, Canada
CAN004

Toronto, Ontario, M5T 3A9, Canada
CHL001

Providencia, Región-MetropolitanadeSantiago, 7500000, Chile
CHL002

Providencia, Región-MetropolitanadeSantiago, 7500000, Chile
CHL004

Quillota, 2260000, Chile
CHL005

Curicó, Maule Region, 3440000, Chile
CHL007

Valdivia, Los Ríos Region, 5110683, Chile
CHL008

Providencia, Región-MetropolitanadeSantiago, 7500587, Chile
CHL010

Talca, Maule Region, 3481349, Chile
COL001

Bogotá, Bogota D.C., 111211, Colombia
COL002

Bogota DC, 110131, Colombia
COL003

Cali, Valle del Cauca Department, 760026, Colombia
COL004

Santiago de Cali, 076001, Colombia
COL005

Floridablanca, Santander Department, 681004, Colombia
COL006

Zipaquirá, Cundinamarca, 250252, Colombia
DEU002

Berlin, 10717, Germany
DEU003

Leipzig, Saxony, 04347, Germany
DEU005

Marburg, Hesse, 35037, Germany
DEU006

Berlin, 13125, Germany
DEU008

Frankfurt am Main, Hesse, 60590, Germany
DEU009

Heidelberg, Baden-Wurttemberg, 69126, Germany
DEU011

Berlin, 13353, Germany
DEU013

Essen, North Rhine-Westphalia, 45239, Germany
DEU014

Dresden, 01307, Germany
DEU015

Hanover, 30625, Germany
DEU016

Halle, Saxony-Anhalt, 06120, Germany
DEU019

Berlin, 10961, Germany
DEU020

Geesthacht, Schleswig-Holstein, 21502, Germany
DEU021

Frankfurt, 60389, Germany
DEU023

Mainz, 55128, Germany
DEU025

München, Bavaria, 80336, Germany
DEU027

Potsdam, Brandenburg, 14467, Germany
DEU029

Münster, 48149, Germany
DEU031

Hanover, Lower Saxony, 30625, Germany
DNK001

Hvidovre, Capital, DK-2650, Denmark
DNK002

Roskilde, 4000, Denmark
DNK003

Aalborg, 9000, Denmark
DNK004

Hellerup, 2900, Denmark
DNK005

Odense C, Region Syddanmark, 5000, Denmark
DNK006

Vejle, Region Syddanmark, 7100, Denmark
DNK007

Aarhus, DK-8200, Denmark
DNK008

Copenhagen O, Capital, 2100, Denmark
ESP001

Girona, 17007, Spain
ESP002

Madrid, Spain
ESP003

Barcelona, 08035, Spain
ESP006

L'Hospitalet de Llobregat, 08907, Spain
ESP007

Madrid, 28007, Spain
ESP008

Oviedo, Principality of Asturias, 33011, Spain
ESP009

Santiago de Compostela, A Coruña, 15706, Spain
ESP011

Pamplona, Navarre, 31008, Spain
ESP012

Santander, Cantabria, 39008, Spain
ESP013

Badalona, Barcelona, 08036, Spain
ESP015

Pozuelo de Alarcón, Madrid, 28223, Spain
ESP016

Barcelona, 8036, Spain
FRA002

Strasbourg, Bas-Rhin, 67091, France
FRA003

Nantes, 44093, France
FRA004

Amiens, 80054, France
FRA005

Montpellier, Hérault, 34295, France
FRA006

Toulouse, 31400, France
FRA009

Nice, 6002, France
FRA010

Paris, 75014, France
FRA011

Créteil, 94010, France
GBR001

Cambridge, Cambridgeshire, CB23 3RE, United Kingdom
GBR002

Chertsey, KT16 0PZ, United Kingdom
GBR003

Newcastle upon Tyne, NE7 7DN, United Kingdom
GBR004

Liverpool, L14 3PE, United Kingdom
GBR006

Birmingham, B9 5SS, United Kingdom
GBR007

Dundee, DDI 9SY, United Kingdom
GBR008

Manchester, M23 9LT, United Kingdom
GBR009

London, SW3 6NP, United Kingdom
GBR010

Swansea, SA6 6NL, United Kingdom
GBR011

Manchester, M8 5RB, United Kingdom
GBR012

Salford, M6 8HD, United Kingdom
GBR013

Llandough, Vale of Glamorgan, the, CF64 2XX, United Kingdom
GBR015

Exeter, Devon, EX2 5DW, United Kingdom
GBR016

Bradford, Yorkshire, BD9 6RJ, United Kingdom
GBR017

Norwich, Norfolk, NR4 7UY, United Kingdom
GBR018

Southampton, SO16 6YD, United Kingdom
GRC003

Alexandroupoli, Evros, 681 00, Greece
GRC006

Thessaloniki, 57010, Greece
GRC007

Heraklion, 71110, Greece
HUN005

Tatabánya, Komárom-Esztergom, 2800, Hungary
IRL001

Limerick, V94 F858, Ireland
IRL002

Dublin, Dublin 8, Ireland
IRL003

Dublin, 15, Ireland
ISR001

Ashkelon, 78278, Israel
ISR002

Jerusalem, 91120, Israel
ISR003

Rehovot, 76100, Israel
ISR004

Ẕerifin, 70300, Israel
ISR006

Jerusalem, 91031, Israel
ISR007

Ramat Gan, 52621, Israel
ISR008

Haifa, 34362, Israel
ISR009

Kefar Sava, 44281, Israel
ISR010

Beersheba, 84101, Israel
ISR011

Petah Tikva, 49100, Israel
ITA001

Palermo, 90127, Italy
ITA002

Reggio Emilia, Emilia-Romagna, 42100, Italy
ITA003

Milan, 20157, Italy
ITA004

Siena, Tuscany, 53100, Italy
ITA006

Milan, Lombardy, 20122, Italy
ITA007

Pavia, 27100, Italy
ITA008

Ferrara, Emilia-Romagna, 44124, Italy
ITA009

Roma, 00168, Italy
ITA010

Bologna, Emilia-Romagna, 40138, Italy
ITA011

Rozzano, Lombardy, 20089, Italy
ITA012

Milan, Lombardy, 20122, Italy
JPN001

Naka-gun, Ibaraki, 319-1113, Japan
JPN002

Shinjuku-ku, Tokyo, 160-8582, Japan
JPN003

Hamamatsu, 434-8511, Japan
JPN004

Kita Kyushu-shi, 807-8556, Japan
JPN005

Koshi Shi, Kumamoto, 861-1196, Japan
JPN006

Shinagawa-ku, Tokyo, 140-8522, Japan
JPN007

Kiyose, Tokyo, 204-8522, Japan
JPN008

Matsusaka-shi, Mie-ken, 515-8544, Japan
JPN009

Kobe, Hyôgo, 650-0047, Japan
JPN010

Meguro-ku, 152-0021, Japan
JPN011

Tsu, Mie-ken, 514-1101, Japan
JPN012

Chuo-ku, Niigata, 951-8510, Japan
JPN013

Nagasaki, Nagasaki, 852-8501, Japan
JPN014

Ōta-ku, Tokyo, 143-8541, Japan
JPN015

Matsue, Shimane, 690-8556, Japan
JPN016

Matsue, 690-8504, Japan
JPN017

Shinagawa-ku, Tokyo, 141-8625, Japan
JPN018

Toyonaka-shi, 560-8552, Japan
JPN019

Shimonoseki-Shi, Yamaguchi, 750-0041, Japan
JPN020

Kasama-Shi, Ibaraki, 309-1703, Japan
JPN022

Takamatsu, Kagawa-ken, 761-8073, Japan
JPN023

Iizuka-Shi, Hukuoka, 820-0018, Japan
JPN027

Fukuoka, Hukuoka, 815-0032, Japan
JPN028

Yokohama-Shi Konan-Ku, Kanagawa, 234-0054, Japan
JPN029

Toyoake, Aiti, 470-1192, Japan
JPN030

Fukuoka, 8408571, Japan
JPN031

Toon-Shi, Ehime, 791-0203, Japan
JPN032

Shinjuku-ku, Tokyo, 1628655, Japan
JPN034

Sendai, Miyagi, 981-0914, Japan
KOR003

Seoul, Seoul Teugbyeolsi, 05030, South Korea
KOR004

Incheon, 21431, South Korea
KOR005

Seoul, 06591, South Korea
KOR007

Seongnam-si, Gyeonggido, 13620, South Korea
KOR008

Bucheon-si, Gyeonggido, 14584, South Korea
KOR009

Seoul, 03312, South Korea
KOR010

Seoul, 06273, South Korea
KOR011

Seoul, 02841, South Korea
KOR012

Seoul, 02447, South Korea
KOR013

Seoul, 03722, South Korea
KOR015

Ansan-si, Gyeonggido, 15355, South Korea
LVA002

Daugavpils, Daugavpils Aprinkis, LV-5401, Latvia
LVA005

Jūrmala, LV-2015, Latvia
MEX001

Monterrey, 64718, Mexico
MEX002

Oaxaca City, 68000, Mexico
MEX003

Monterrey, Nuevo León, 64460, Mexico
MEX004

Guadalajara, Jalisco, 44700, Mexico
MEX005

Guadalajara, Jalisco, 44220, Mexico
MEX006

Durango, 34080, Mexico
MEX007

Guadalajara, Jalisco, 44160, Mexico
MEX008

Guadalajara, Jalisco, 44160, Mexico
MYS001

Kuala Lumpur, WilayahPersekutuan KualaLumpur, 50603, Malaysia
MYS003

Kota Bharu, 16150, Malaysia
MYS004

Kuantan, Pahang, 25100, Malaysia
MYS005

Kuala Lumpur, 50590, Malaysia
NLD001

Alkmaar, North Holland, 1815 JD, Netherlands
NLD002

Amsterdam, North Holland, 1105 AZ, Netherlands
NLD003

Arnhem, Gelderland, 6815 AD, Netherlands
NLD006

Rotterdam, 3015 GD, Netherlands
NZL001

Dunedin, South Island, 9001, New Zealand
NZL002

Hamilton, Waikato Region, 3204, New Zealand
NZL003

Auckland, 1051, New Zealand
NZL005

Christchurch, South Island, 8011, New Zealand
NZL006

Otahuhu, Auckland, 1640, New Zealand
NZL007

Tauranga, 3110, New Zealand
NZL008

Auckland, 1051, New Zealand
NZL009

Hastings, Hawkes's Bay, 4122, New Zealand
NZL010

Wellington, 6021, New Zealand
NZL011

Paraparaumu, Wellington Region, 5032, New Zealand
PER001

Lima, 15001, Peru
PER002

Lima, 15084, Peru
PER003

Lima, 15036, Peru
PER005

Chancay, 15131, Peru
PER006

Piura, 20001, Peru
POL001

Sucha Beskidzka, 34-200, Poland
POL005

Bialystok, 15-044, Poland
POL006

Bielsko-Biala, 43-300, Poland
POL007

Sosnowiec, 41-208, Poland
POL008

Rabka-Zdrój, 34-700, Poland
POL009

Tarnów, 33-100, Poland
POL010

Siedlce, 08-110, Poland
POL011

Rzeszów, 35-051, Poland
POL012

Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, 27-400, Poland
POL014

Szczecin, 70-111, Poland
POL015

Kielce, 25-751, Poland
POL016

Katowice, 40-081, Poland
POL017

Krakow, 30-510, Poland
POL018

Ksawerów, 95-054, Poland
PRT002

Guimarães, 4835-044, Portugal
PRT003

Lisbon, 1649-035, Portugal
PRT005

Aveiro, 3814-501, Portugal
PRT006

Guarda, 6300-858, Portugal
PRT009

Braga, 4710-243, Portugal
SRB001

Belgrade, 11000, Serbia
SRB003

Belgrade, 11000, Serbia
SRB007

Niš, 18000, Serbia
SRB010

Užice, 31000, Serbia
SRB014

Sombor, 25000, Serbia
SVK002

Bardejov, 085 01, Slovakia
SVK003

Spisská Nová Ves, 052 01, Slovakia
THA002

Muang, Changwat Nonthaburi, 11000, Thailand
THA003

Khon Kaen, 40002, Thailand
THA004

Nakhonnayok, Changwat Nakhon Nayok, 26120, Thailand
TUR001

Mersin, 33079, Turkey (Türkiye)
TUR003

Çanakkale, 17110, Turkey (Türkiye)
TUR004

Izmir, 35110, Turkey (Türkiye)
TUR005

Konya, 42075, Turkey (Türkiye)
TUR006

Atakum, Samsun, 55270, Turkey (Türkiye)
TUR008

Izmir, 35100, Turkey (Türkiye)
TUR009

Kocaeli, 41380, Turkey (Türkiye)
TUR010

Ankara, 6010, Turkey (Türkiye)
TUR011

Ankara, 6340, Turkey (Türkiye)
TWN001

Kaohsiung City, 833, Taiwan
TWN002

Kaohsiung City, 82544, Taiwan
TWN003

Kaohsiung City, 80756, Taiwan
TWN004

Taipei, 11217, Taiwan
TWN005

New Taipei City, 22060, Taiwan
TWN006

Taipei, 11490, Taiwan
TWN007

Taipei, 10002, Taiwan
UKR001

Kharkiv, Kharkivs’ka Oblast’, 61124, Ukraine
UKR003

Odesa, 65025, Ukraine
UKR004

Kyiv, 03038, Ukraine
UKR005

Poltava, Poltava Oblast, 36010, Ukraine
UKR007

Kherson, Kherson Oblast, 73003, Ukraine
UKR008

Kyiv, 01033, Ukraine
UKR009

Ivano-Frankivsk, 76018, Ukraine
UKR010

Vinnytsia, 21018, Ukraine
UKR012

Dnipro, 49102, Ukraine
USA001

Washington D.C., District of Columbia, 20007, United States
USA002

Tyler, Texas, 75708, United States
USA003

Baltimore, Maryland, 21224, United States
USA005

Charleston, South Carolina, 29425, United States
USA006

Chesterfield, Missouri, 63017, United States
USA010

Rochester, Minnesota, 55905, United States
USA011

San Antonio, Texas, 78258, United States
USA012

Atlanta, Georgia, 30342, United States
USA013

Birmingham, Alabama, 35233, United States
USA015

Clearwater, Florida, 33765, United States
USA017

Farmington, Connecticut, 06030, United States
USA019

Miami Lakes, Florida, 33014, United States
USA020

New Orleans, Louisiana, 70112, United States
USA021

New York, New York, 10017, United States
USA022

Palm Springs, California, 92262, United States
USA023

Portland, Oregon, 97239, United States
USA024

Sacramento, California, 95817, United States
USA026

Winston-Salem, North Carolina, 27103, United States
USA027

Ventura, California, 93003, United States
USA029

Newport Beach, California, 92663, United States
USA031

Kansas City, Kansas, 66160, United States
USA033

Gastonia, North Carolina, 28054, United States
USA034

Williamsburg, Virginia, 23188, United States
USA035

San Diego, California, 92120, United States
USA036

Rock Hill, South Carolina, 29732, United States
USA037

Miami, Florida, 33126, United States
USA038

DuBois, Pennsylvania, 15801, United States
USA039

Kissimmee, Florida, 34746, United States
USA041

Franklin, Tennessee, 37067, United States
USA044

Little Rock, Arkansas, 72205, United States
USA046

Philadelphia, Pennsylvania, 19104, United States
USA049

Naples, Florida, 34102, United States
USA050

McKinney, Texas, 75069, United States
USA051

New Orleans, Louisiana, 70112, United States
USA052

Orlando, Florida, 32825, United States
USA053

Augusta, Georgia, 30912, United States
USA055

Los Angeles, California, 90048, United States
USA059

St Louis, Missouri, 63110, United States
USA061

Maywood, Illinois, 60153, United States
USA063

Iowa City, Iowa, 52242, United States
USA064

Springfield, Massachusetts, 01199, United States
USA065

Toms River, New Jersey, 08755, United States
USA066

New Hyde Park, New York, 11042, United States
USA067

Cincinnati, Ohio, 45267, United States
USA072

Leesburg, Florida, 34748, United States
USA073

Chicago, Illinois, 60611, United States
USA074

St. Petersburg, Florida, 33707, United States
USA075

Denver, Colorado, 80206, United States
USA076

Gainesville, Florida, 32610, United States
USA078

Santa Barbara, California, 93105, United States
USA079

Boston, Massachusetts, 02114, United States
USA080

Conway, Arkansas, 72032, United States
USA082

Jacksonville, Florida, 32224, United States
USA084

Sarasota, Florida, 34239, United States
USA085

New York, New York, 10032, United States
USA088

Vancouver, Washington, 98664, United States
USA089

St. Petersburg, Florida, 33704, United States
USA093

Cleveland, Ohio, 44195, United States
USA096

Huntersville, North Carolina, 28078, United States
USA097

Dallas, Texas, 75246, United States
USA102

Northridge, California, 91324, United States
USA103

Plantation, Florida, 33324, United States
USA104

Fresno, California, 93702, United States
USA109

Nashville, Tennessee, 37232, United States
USA110

Lincoln, Nebraska, 68510, United States
USA115

Hammond, Indiana, 46324, United States
USA120

Tampa, Florida, 33606, United States

Conditions

Explore the condition pages connected to this study.

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