New pill challenges chemo for rare cancer

NCT ID NCT05218499

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

Summary

This study tested whether a new oral medication called brigimadlin could work better than standard chemotherapy (doxorubicin) for people with advanced dedifferentiated liposarcoma, a rare and aggressive cancer. 400 adults who hadn't received prior treatment for this cancer were randomly assigned to receive either the new pill or the standard IV chemotherapy. Researchers measured how long patients lived without their cancer getting worse, tumor shrinkage, side effects, and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

"Attikon" University General Hospital of Attica

Haidari, 12462, Greece
AOU San Luigi Gonzaga

Orbassano (TO), 10043, Italy
Abdurrahman Yurtaslan Oncology Training and Research Hospital

Ankara, 06200, Turkey (Türkiye)
Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Aichi Cancer Center Hospital

Aichi, Nagoya, 464-8681, Japan
Ashford Cancer Centre Research

Kurralta Park, South Australia, 5037, Australia
Asklepios Kliniken GmbH & Co. KGaA

Hamburg, 22763, Germany
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

Palermo, 90129, Italy
BC Cancer Agency - Vancouver

Vancouver, British Columbia, V5Z 4E6, Canada
Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Beijing Cancer Hospital

Beijing, 100142, China
Bioclinic Thessaloniki

Thessaloniki, 54622, Greece
CTR Eugène Marquis

Rennes, 35042, France
CTR Leon Berard

Lyon, 69373, France
CTR Oscar Lambret

Lille, 59020, France
Cancer Hospital of Chinese Academy of Medical Science

Beijing, 100021, China
Churchill Hospital

Headington, OX3 9DS, United Kingdom
City of Hope-Duarte-56419

Duarte, California, 91010, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy
Froedtert and The Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Fundación Jiménez Díaz

Madrid, 28040, Spain
HOP Timone

Marseille, 13385, France
HUCH Comprehensive Cancer Center, building 2

Helsinki, 00290, Finland
Harbin Medical University Cancer Hospital

Harbin, 150081, China
Helios Klinikum Bad Saarow

Bad Saarow, 15526, Germany
Helios Klinikum Berlin-Buch

Berlin, 13125, Germany
Henry-Joyce Cancer Clinic

Nashville, Tennessee, 37232, United States
Herlev and Gentofte Hospital

Herlev, 2730, Denmark
Hippokration General Hospital of Athen

Athens, 115 27, Greece
Hokkaido Cancer Center

Sapporo, Hokkaido, 003-0804, Japan
Hospital Clínico de Santiago

Santiago de Compostela, 15706, Spain
Hospital Duran i Reynals

L'Hospitalet de Llobregat, 08907, Spain
Hospital General Universitario Gregorio Marañón

Madrid, 28007, Spain
Hospital Santa Creu i Sant Pau

Barcelona, 08026, Spain
Hospital Universitari Vall D Hebron

Barcelona, 08035, Spain
Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain
Hospital Universitario Virgen de la Victoria

Málaga, 29010, Spain
Humanitas Gavazzeni

Bergamo, 24125, Italy
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Hôpital Cochin

Paris, 75014, France
INS Bergonie

Bordeaux, 33000, France
INS Claudius Regaud IUCT-Oncopole

Toulouse, 31059, France
IPO Lisboa Francisco Gentil, EPE

Lisbon, 1099-023, Portugal
Institut Gustave Roussy

Villejuif, 94805, France
Istituto Di Candiolo

Candiolo (TO), 10060, Italy
Istituto Nazionale IRCCS Tumori Fondazione Pascale

Napoli, 80131, Italy
Istituto Oncologico Veneto IRCCS

Padua, 35128, Italy
Japanese Foundation for Cancer Research

Tokyo, Koto-ku, 135-8550, Japan
Karolinska Universitetssjukhuset Stockholm

Stockholm, 17177, Sweden
Klinikum der Universität München AÖR

München, 81377, Germany
Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan
Leids Universitair Medisch Centrum (LUMC)

Leiden, 2333 ZA, Netherlands
Maisonneuve-Rosemont Hospital

Montreal, Quebec, H1T 2M4, Canada
Masaryk Memorial Cancer Institute

Brno, 65653, Czechia
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Cancer Center

Jacksonville, Florida, 32224, United States
Mayo Clinic, Rochester

Rochester, Minnesota, 55905, United States
Medizinische Hochschule Hannover

Hanover, 30625, Germany
Nagoya University Hospital

Aichi, Nagoya, 466-8560, Japan
National Cancer Center Hospital

Tokyo, Chuo-ku, 104-0045, Japan
National Cancer Center Hospital East

Chiba, Kashiwa, 277-8577, Japan
National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan
National Taiwan University Hospital

Taipei, 100, Taiwan
Nebraska Cancer Specialists-Omaha-69502

Omaha, Nebraska, 68114, United States
Nederlands Kanker Instituut

Amsterdam, 1066 CX, Netherlands
Okayama University Hospital

Okayama, Okayama, 700-8558, Japan
Oregon Health and Sciences University

Portland, Oregon, 97239, United States
Osaka International Cancer Institute

Osaka, Osaka, 541-8567, Japan
Oslo Universitetssykehus HF, Radiumhospitalet

Oslo, N-0379, Norway
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Precision NextGen Oncology

Beverly Hills, California, 90212, United States
Prince of Wales Hospital-Hong Kong-20715

Hong Kong, Hong Kong
Prince of Wales Hospital-Randwick-66496

Randwick, New South Wales, 2031, Australia
Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Robert Bosch Gesellschaft für medizinische Forschung mbH

Stuttgart, 70376, Germany
Sarcoma Oncology Center

Santa Monica, California, 90403, United States
Skånes universitetssjukhus

Lund, 22185, Sweden
Sun Yat-Sen University Cancer Center

Guangzhou, 510060, China
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Tampere University Hospital

Tampere, 33520, Finland
Technische Universität Dresden

Dresden, 01307, Germany
The First Hospital of Jilin University

Changchun, 130021, China
The Ottawa Hospital

Ottawa, Ontario, K1H 8L6, Canada
The Royal Marsden Hospital, Chelsea

London, SW3 6JJ, United Kingdom
Tohoku University Hospital

Miyagi, Sendai, 980-8574, Japan
ULS de Santa Maria, E.P.E

Lisbon, 1649-035, Portugal
UZ Leuven

Leuven, 3000, Belgium
University College Hospital

London, NW1 2BU, United Kingdom
University Hospital Motol

Prague, 150 06, Czechia
University Hospital Olomouc

Olomouc, 77900, Czechia
University Hospitals of Cleveland

Cleveland, Ohio, 44106, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
University of Arizona

Tucson, Arizona, 85719, United States
University of Michigan Health System

Ann Arbor, Michigan, 48109, United States
University of Southern California

Los Angeles, California, 90033, United States
University of Texas Southwestern Medical Center

Dallas, Texas, 75390, United States
Università Campus Bio-Medico - ROMA

Roma, 00128, Italy
Universitätsklinikum Essen AöR

Essen, 45147, Germany
Universitätsklinikum Mannheim GmbH

Mannheim, 68167, Germany
Velindre Cancer Centre

Cardiff, CF14 2TL, United Kingdom
West China Hospital, Sichuan University

Chengdu, 610041, China
Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Wuhan Union Hospital

Wuhan, 430022, China
Zhejiang Cancer Hospital

Hangzhou, 310022, China
Zhongshan Hospital Affiliated to Fudan University

Shanghai, 200032, China

Conditions

Explore the condition pages connected to this study.

LIPOSARCOMA, DEDIFFERENTIATED