New cancer pill shows promise against rare, aggressive fat tissue tumors

NCT ID NCT06058793

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

Summary

This completed Phase 3 trial tested whether a new oral medication called brigimadlin helps control advanced dedifferentiated liposarcoma, a rare and aggressive cancer of fat tissue. The study involved 138 adults with this cancer who took brigimadlin tablets once every three weeks for as long as they benefited. Researchers monitored participants' health, side effects, and tumor size to determine if the treatment was safe and effective.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Abramson Cancer Center at Pennsylvania Hospital

Philadelphia, Pennsylvania, 19106, United States
Addenbrooke's Hospital

Cambridge, CB2 0QQ, United Kingdom
Aichi Cancer Center Hospital

Aichi, Nagoya, 464-8681, Japan
Arthur J. E. Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Beatson West of Scotland Cancer Centre

Glasgow, G12 0YN, United Kingdom
CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia

Santo André, 09060-650, Brazil
Duke University Medical Center

Durham, North Carolina, 27710, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Froedtert and The Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
H.S.J. Beneficência Portuguesa - São Paulo

São Paulo, 01323-001, Brazil
Hokkaido Cancer Center

Sapporo, Hokkaido, 003-0804, Japan
Hospital Britanico de Buenos Aires

CABA, 1280AEB, Argentina
Hospital Italiano de Buenos Aires

CABA, C1199ABB, Argentina
Hospital Sao Domingos

São Luís, 65060-645, Brazil
Hospital do Cancer de Londrina

Londrina, 86015-520, Brazil
Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Instituto Medico Especializado Alexander Fleming

Ciudad Autonoma de Bs As, C1426ANZ, Argentina
Japanese Foundation for Cancer Research

Tokyo, Koto-ku, 135-8550, Japan
John Theurer Cancer Center

Hackensack, New Jersey, 07601, United States
Kyushu University Hospital

Fukuoka, Fukuoka, 812-8582, Japan
Mayo Clinic - Florida

Jacksonville, Florida, 32224, United States
Mayo Clinic, Rochester

Rochester, Minnesota, 55905, United States
Mayo Clinic-Arizona

Phoenix, Arizona, 85054, United States
McGill University Health Centre (MUHC)

Montreal, Quebec, H4A 3J1, Canada
Medical Oncology Associates, P.S.

Spokane, Washington, 99208, United States
Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States
Nagoya University Hospital

Aichi, Nagoya, 466-8560, Japan
National Cancer Center Hospital East

Chiba, Kashiwa, 277-8577, Japan
National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
Northwell Health

Lake Success, New York, 11042, United States
Northwestern University

Chicago, Illinois, 60611, United States
Okayama University Hospital

Okayama, Okayama, 700-8558, Japan
Osaka International Cancer Institute

Osaka, Osaka, 541-8567, Japan
Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia
Precision NextGen Oncology

Beverly Hills, California, 90212, United States
Prince of Wales Hospital-Randwick-66496

Randwick, New South Wales, 2031, Australia
Princess Alexandra Hospital

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Cancer Centre

Toronto, Ontario, M5G 2M9, Canada
Pronutrir

Fortaleza, 60810-180, Brazil
Sanatorio Finochietto

CABA, C1120AAB, Argentina
Sarcoma Oncology Center

Santa Monica, California, 90403, United States
Sir Charles Gairdner Hospital

Nedlands, Western Australia, 6009, Australia
The Christie

Manchester, M20 4BX, United Kingdom
The Royal Marsden Hospital, Chelsea

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center

Houston, Texas, 77030, United States
Tohoku University Hospital

Miyagi, Sendai, 980-8574, Japan
University Cancer and Blood Center

Athens, Georgia, 30607, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35249, United States
University of California Los Angeles

Santa Monica, California, 90404, United States
University of Kansas Cancer Center

Overland Park, Kansas, 66210, United States
Utah Cancer Specialists Cancer Center

Salt Lake City, Utah, 84106, United States
Virginia Cancer Specialists, PC

Fairfax, Virginia, 22031, United States
Washington University School of Medicine

St Louis, Missouri, 63108, United States
West Cancer Center & Research Institute

Germantown, Tennessee, 38138, United States
Yale Cancer Center

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

LIPOSARCOMA, DEDIFFERENTIATED