Radiation boost before chemo may supercharge immune attack on breast cancer
NCT ID NCT04443348
Summary
This study is testing whether adding a targeted dose of radiation to the breast tumor before starting standard chemotherapy and an immunotherapy drug (pembrolizumab) makes the treatment more effective. It is for people with breast cancer that has spread to lymph nodes and is either triple-negative or hormone receptor-positive/HER2-negative. The main goal is to see if this combination helps the body's own immune system better recognize and destroy cancer cells.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Johns Hopkins
Baltimore, Maryland, 21231, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02115, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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University of North Carolina Medical Center
Chapel Hill, North Carolina, 27514, United States
Conditions
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