New hope for advanced breast cancer: major trial tests promising drug combo

NCT ID NCT04546009

Summary

This large Phase 3 trial is testing whether a new drug called giredestrant, when combined with palbociclib, works better than the current standard treatment (letrozole + palbociclib) for people with a specific type of advanced breast cancer. The study involves 992 patients whose cancer has spread or returned and is fueled by estrogen but not HER2. The main goal is to see if the new combination can keep the cancer from growing for a longer time while monitoring side effects and quality of life.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • 19 Mayis University Medical Faculty

    Samsun, 55139, Turkey (Türkiye)

  • A.Ö. LHK

    Steyr, 4400, Austria

  • Affiliated Hospital of Hebei University

    Baoding, 071000, China

  • Ambulantes Tumorzentrum Spandau

    Berlin, 13581, Germany

  • Ankara Bilkent City Hospital

    Ankara, 06490, Turkey (Türkiye)

  • Anticancer Hospital Ag Savas

    Athens, 115 22, Greece

  • Anticancer Hospital Ag. Savas

    Athens, 115 22, Greece

  • Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde

    Morelia, 58260, Mexico

  • Anyang Tumor Hosptial

    Anyang, 455000, China

  • Arthur J.E. Child Comprehensive Cancer Center-Calgary

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Asst Di Monza

    Monza, Lombardy, 20900, Italy

  • Astera Cancer Care East Brunswick

    East Brunswick, New Jersey, 08816, United States

  • Auckland City Hospital

    Auckland, 1023, New Zealand

  • Az. Osp. Spedali Civili

    Brescia, Lombardy, 25123, Italy

  • Azienda ULSS 8 Berica

    Vicenza, Veneto, 36100, Italy

  • BC Cancer ? Surrey

    Surrey, British Columbia, V3V 1Z2, Canada

  • Baylor St. Luke's Medical Center

    Houston, Texas, 77030, United States

  • Beijing Cancer Hospital

    Beijing, 100142, China

  • Beneficencia Portuguesa de Sao Paulo

    São Paulo, São Paulo, 01323-900, Brazil

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Budapesti Uzsoki Utcai Kórház

    Budapest, 1145, Hungary

  • CEMER Centro Medico de Enfermedades Respiratorias

    Vicente López, B1602DQD, Argentina

  • Calvary Mater Newcastle

    Waratah, New South Wales, 2298, Australia

  • Centre Alexis Vautrin

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Eugene Marquis

    Rennes, 35042, France

  • Centre Hospitalier de La Cote Basque

    Bayonne, 64109, France

  • Centre Hospitalier de l?Université de Montréal (CHUM)

    Montreal, Quebec, H2X 3E4, Canada

  • Centro Hospitalar Lisboa Norte

    Lisbon, Portugal

  • Centro Oncologico MD Anderson Internacional

    Madrid, 28033, Spain

  • Centro de Atencion Oncologica Viva S de RL de CV

    Mexico City, Mexico CITY (federal District), 06760, Mexico

  • Centro de Investigacion Clinica de Oaxaca

    Oaxaca City, Oaxaca, 68020, Mexico

  • Centro de Investigaciones Médicas y Desarrollo LC S.R.L

    Buenos Aires, Ciudad Autónoma de BuenosAires, C1113AAE, Argentina

  • Chaim Sheba Medical Center

    Ramat Gan, 52620-00, Israel

  • Chang Gung Memorial Hosipital at Linkou

    Taoyuan Hsien, 333, Taiwan

  • Chd de Vendee

    La Roche-sur-Yon, 85925, France

  • Chelyabinsk region oncology dispensary

    Chelyabinsk, 454087, Russia

  • Chiba Cancer Center

    Chiba, 260-8717, Japan

  • China Medical University Hospital

    Taichung, 404, Taiwan

  • Chu La Miletrie

    Poitiers, 86021, France

  • Chulalongkorn Hospital, Faculty of Medicine

    Bangkok, 10330, Thailand

  • Chungbuk National University Hospital

    Cheongju-si, 28644, South Korea

  • Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

    São Paulo, São Paulo, 01317-000, Brazil

  • Cliniques Universitaires St-Luc

    Brussels, 1200, Belgium

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, 15006, Spain

  • Corporacio Sanitaria Parc Tauli

    Sabadell, Barcelona, 8208, Spain

  • Davidof Center - Rabin Medical Center

    Petah Tikva, 49100, Israel

  • Derriford Hospital

    Plymouth, PL6 8DH, United Kingdom

  • Dres. Andreas Köhler und Roswitha Fuchs

    Langen, 63225, Germany

  • Dres. Helmut Forstbauer, Carsten Ziske und Kollegen

    Troisdorf, 53840, Germany

  • Dres.Andreas Ammon und Dirk Meyer

    Göttingen, 37073, Germany

  • Euromedical General Clinic of Thessaloniki

    Thessaloniki, 546450, Greece

  • European Interbalkan Medical Center

    Thessaloniki, 570 01, Greece

  • Facharztzentrum Eppendorf, Studien GbR

    Hamburg, 20249, Germany

  • Filios Alta Medicina

    Monterrey, Nuevo León, 64460, Mexico

  • Fiona Stanley Hospital - Medical Oncology

    Murdoch, Western Australia, 6150, Australia

  • Florida Cancer Specialists - Fort Myers (Broadway)

    Fort Myers, Florida, 33901, United States

  • Fondazione del Piemonte per l?Oncologia (IRCCS)

    Candiolo, Trentino-Alto Adige, 10060, Italy

  • Fujian Medical University Union Hospital

    Fujian, 350001, China

  • Fukushima Medical University Hospital

    Miyagi, 960-1295, Japan

  • GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)

    Saint Petersburg, Sankt-Peterburg, 197758, Russia

  • Gachon University Gil Medical Center

    Incheon, 21565, South Korea

  • Gangnam Severance Hospital

    Seoul, 06273, South Korea

  • Guangxi Cancer Hospital of Guangxi Medical University

    Nanning, 530021, China

  • Guys & St Thomas Hospital

    London, SE1 9RT, United Kingdom

  • HCA Midwest Division

    Kansas City, Missouri, 64132, United States

  • HM Sanchinarro ? CIOCC

    Madrid, 28050, Spain

  • Hacettepe Uni Medical Faculty Hospital

    Ankara, 06100, Turkey (Türkiye)

  • Harbin Medical University Cancer Hospital

    Harbin, 150081, China

  • Health Pharma Professional Research

    CD Mexico, Mexico CITY (federal District), 03810, Mexico

  • Herlev Hospital

    Herlev, 2730, Denmark

  • Hiroshima City Hiroshima Citizens Hospital

    Hiroshima, 730-8518, Japan

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Honvédelmi Minisztérium Állami Egészségügyi Központ;Onkológiai Osztály

    Budapest, 1062, Hungary

  • Hopital du Saint Sacrement

    Québec, Quebec, G1S 4L8, Canada

  • Hospital Araujo Jorge

    Goiânia, Goiás, 74605-070, Brazil

  • Hospital Britanico

    Ciudad Autonoma Bs As, C1280AEB, Argentina

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Clinico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28007, Spain

  • Hospital Provincial del Centenario

    Rosario, 2000, Argentina

  • Hospital Quiron de Madrid

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Ramon y Cajal

    Madrid, 28034, Spain

  • Hospital Sao Lucas - PUCRS

    Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

  • Hospital Sao Rafael - HSR

    Salvador, Estado de Bahia, 41253-190, Brazil

  • Hospital Universitari Dexeus - Grupo Quironsalud

    Barcelona, 08028, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, 41013, Spain

  • Hospital da Luz

    Lisbon, 1500-650, Portugal

  • Hospital de Base de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital de Donostia

    Donostia / San Sebastian, Guipuzcoa, 20080, Spain

  • Hospital de Onc Angel Roffo

    Buenos Aires, 1425, Argentina

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Hospital do Cancer de Pernambuco - HCP

    Recife, Pernambuco, 50040-000, Brazil

  • Houston Methodist Hospital

    Houston, Texas, 77030, United States

  • Humanitas Centro Catanese Di Oncologia

    Misterbianco (CT), Sicily, 95045, Italy

  • Hunan Cancer Hospital

    Changsha, 410013, China

  • Hyogo Cancer Center

    Hyōgo, 673-0021, Japan

  • ICL

    Saint-Priest-en-Jarez, 42271, France

  • ICO Paul Papin

    Angers, 49055, France

  • IOV - Istituto Oncologico Veneto - IRCCS

    Padua, Veneto, 35128, Italy

  • IPO de Coimbra

    Coimbra, 3000-075, Portugal

  • IPO do Porto

    Porto, 4200-072, Portugal

  • IRCCS Istituto Regina Elena (IFO)

    Rome, Lazio, 00144, Italy

  • IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola

    Meldola, Emilia-Romagna, 47014, Italy

  • Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department

    Malatya, 44280, Turkey (Türkiye)

  • Inova Fairfax Hospital

    Fairfax, Virginia, 22031, United States

  • Institut Jean Godinot

    Reims, 51056, France

  • Institut régional du Cancer Montpellier

    Montpellier, 34298, France

  • Instituto Nacional de Enfermedades Neoplasicas

    Lima, Lima 34, Peru

  • Instituto Peruano de Oncología y Radioterapia

    Lima, Lima 27, Peru

  • Instituto Regional de Enfermedades Neoplasicas - IREN Norte

    Trujillo, 13014, Peru

  • Instituto de Oncología de Rosario

    Rosario, S2000KZE, Argentina

  • Istituto Europeo Di Oncologia

    Milan, Lombardy, 20141, Italy

  • Ivano-Frankivsk Regional Oncology Center

    Ivano-Frankivsk, 76018, Ukraine

  • Jessa Zkh (Campus Virga Jesse)

    Hasselt, 3500, Belgium

  • Jewish General Hospital

    Montreal, Quebec, H3T 1E2, Canada

  • Kaiser Permanente - Moanalua Medical Center

    Honolulu, Hawaii, 96819-1469, United States

  • Kaiser Permanente - San Leandro Medical Center

    San Leandro, California, 94577, United States

  • Kaiser Permanente - Walnut Creek

    Walnut Creek, California, 94596, United States

  • Kanagawa Cancer Center

    Kanagawa, 241-8515, Japan

  • Katip Celebi University Ataturk Training and Research Hospital

    Izmir, 35360, Turkey (Türkiye)

  • Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt

    München, 80336, Germany

  • Klinikum Chemnitz gGmbH

    Chemnitz, 09116, Germany

  • Klinikum Mutterhaus der Borromaeerinnen gGmbH

    Trier, 54290, Germany

  • Kocaeli University Faculty of Medicine

    İzmit, 31380, Turkey (Türkiye)

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Korea University Guro Hospital

    Seoul, 8308, South Korea

  • Kumamoto University Hospital

    Kumamoto, 860-8556, Japan

  • Kyungpook National University Medical Center

    Daegu, 41944, South Korea

  • Leicester Royal Infirmary

    Leicester, LE1 5WW, United Kingdom

  • Liaoning cancer Hospital & Institute

    Shenyang, 110042, China

  • Long Beach Memorial Medical Center

    Long Beach, California, 90806, United States

  • ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council

    Kryvyi Rih, 50048, Ukraine

  • MSKCC @ Commack

    Commack, New York, 11725, United States

  • MVZ für Hämatologie und Onkologie Ravensburg GmBH

    Ravensburg, 88212, Germany

  • Mackay Memorial Hospital

    Taipei, 104, Taiwan

  • Maharaj Nakorn Chiang Mai Hosp

    Chang Mai, 50200, Thailand

  • Maidstone Hospital

    Maidstone, ME16 0FS, United Kingdom

  • Maryland Oncology Hematology

    Silver Spring, Maryland, 20902, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mater Hospital Brisbane

    South Brisbane, Queensland, 4101, Australia

  • McGill University Health Center

    Montreal, Quebec, H4A 3J1, Canada

  • Medipol University Medical Faculty

    Istanbul, 34214, Turkey (Türkiye)

  • Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie

    Hanover, 30625, Germany

  • Medizinische Universität Wien

    Vienna, 1090, Austria

  • Memorial Regional Cancer Ctr

    Hollywood, Florida, 33021, United States

  • Memorial Sloan Kettering Cancer Center Basking Ridge

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering Cancer Center at Bergen

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan-Kettering Cancer Center

    New York, New York, 10065, United States

  • Mercy Medical Center

    Baltimore, Maryland, 21202, United States

  • Multidisciplinary clinic Reaviz

    Samara, 443011, Russia

  • Municipal Institution City Clinical Hospital #4 of Dnipro City Council

    Dnipropetrovsk, Katerynoslav Governorate, 49102, Ukraine

  • Nagoya University Hospital

    Aichi, 466-8560, Japan

  • Naha-nishi Clinic

    Okinawa, 901-0154, Japan

  • Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad

    Warsaw, 02-781, Poland

  • National Cancer Center

    Gyeonggi-do, 10408, South Korea

  • National Cancer Center Hospital

    Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East

    Chiba, 277-8577, Japan

  • National Cheng Kung Uni Hospital

    Tainan, 704, Taiwan

  • National Hospital Organization Hokkaido Cancer Center

    Hokkaido, 003-0804, Japan

  • National Hospital Organization Kyushu Cancer Center

    Fukuoka, 811-1395, Japan

  • National Hospital Organization Osaka National Hospital

    Osaka, 540-0006, Japan

  • National Taiwan Uni Hospital

    Taipei, 100, Taiwan

  • Nationales Centrum für Tumorerkrankungen (NCT)

    Heidelberg, 69120, Germany

  • Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH

    Georgsmarienhütte, 49124, Germany

  • Niigata Cancer Center Hospital

    Niigata, 951-8566, Japan

  • Northwest Medical Specialties

    Tacoma, Washington, 98405, United States

  • Odense Universitetshospital, Onkologisk Afdeling R

    Odense C, 5000, Denmark

  • Oncologico Potosino

    San Luis Potosí City, San Luis Potosí, 78209, Mexico

  • Oncosalud Sac

    Lima, 41, Peru

  • Orange Coast Memorial Medical Center

    Fountain Valley, California, 92708, United States

  • Organización medica de Investi

    Cap Fed, 1015, Argentina

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Ospedale Civile - Livorno

    Livorno, Tuscany, 57124, Italy

  • Ospedale Sacro Cuore Don Calabria

    Negrar, Veneto, 37024, Italy

  • Ottawa Hospital Research Institute

    Ottawa, Ontario, K1Y 4E9, Canada

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong, Hong Kong

  • Peter MacCallum Cancer Centre-East Melbourne

    Melbourne, Victoria, 3000, Australia

  • Peterborough City Hospital

    Peterborough, PE3 9GZ, United Kingdom

  • Podolsk City Clinical Hospital

    Podolsk, Moscow Oblast, 142100, Russia

  • Praxis Köppler, Heymann, Weide, Thomalla

    Koblenz, 56068, Germany

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Princess Margaret Cancer Center

    Toronto, Ontario, M5G 2M9, Canada

  • Princess Margaret Hospital

    Hong Kong, Hong Kong

  • Providence Portland Medical Ctr

    Portland, Oregon, 97213, United States

  • Queen Mary Hospital

    Hong Kong, Hong Kong

  • Rajavithi Hospital

    Bangkok, 10400, Thailand

  • Ramathibodi Hospital

    Bangkok, 10400, Thailand

  • Regional Clinical Oncology Hospital

    Yaroslavl, 150040, Russia

  • Respublikanskiy Onkologicheskiy Dispanser

    Saransk, Respublika Mordoviya, 430032, Russia

  • Rocky Mountain Cancer Center

    Denver, Colorado, 80218, United States

  • Roper St. Francis Healthcare

    Charleston, South Carolina, 29414, United States

  • Royal Cornwall Hospital

    Truro, TR1 3LQ, United Kingdom

  • Royal Free Hospital

    London, NW3 2QS, United Kingdom

  • Royal Marsden Hosp NHS Fnd

    Sutton, SM2 5PT, United Kingdom

  • Royal Sussex County Hospital

    Brighton, BN2 5BE, United Kingdom

  • Royal Victoria Regional Health Centre

    Barrie, Ontario, L4M 6M2, Canada

  • Ryazan Regional clinical oncology dispensary

    Ryazan, Ryazan Oblast, 390011, Russia

  • SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"

    Moskva, Moscow Oblast, 111123, Russia

  • SCRI Florida Cancer Specialists North

    St. Petersburg, Florida, 33705, United States

  • SCRI Florida Cancer Specialists PAN

    Tallahassee, Florida, 32308, United States

  • SI Institute of general&urgent surgery n/a Zaytseva V.T NAMSU

    Kharkiv, Kharkiv Governorate, 61018, Ukraine

  • Sagara Hospital

    Kagoshima, 892-0833, Japan

  • Saitama Cancer Center

    Saitama, 362-0806, Japan

  • Samsung Medical Center

    Seoul, 06351, South Korea

  • San Juan Oncology Associates

    Farmington, New Mexico, 87401, United States

  • Santa Casa de Misericordia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90050-170, Brazil

  • Sarah Cannon Research Institute / Tennessee Oncology

    Nashville, Tennessee, 37203, United States

  • Seoul National University Bundang Hospital

    Gyeonggi-do, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722, South Korea

  • Shandong Cancer Hospital

    Jinan, 250117, China

  • Shengjing Hospital of China Medical University

    Shenyang, 110004, China

  • Showa Medical University Hospital

    Tokyo, 142-8666, Japan

  • Sir Run Run Shaw Hospital Zhejiang University

    Hangzhou, 310016, China

  • Sjællands Universitetshospital, Næstved

    Næstved, 4700, Denmark

  • Sociedad de Metabolismo y Corazón (SOMECO)

    Veracruz, 91900, Mexico

  • Songklanagarind Hospital

    Songkhla, 90110, Thailand

  • St. Elisabeth-Krankenhaus, Senologie/Brustzentrum

    Leipzig, 04277, Germany

  • Stanford Univ Medical Center

    Stanford, California, 94305, United States

  • Sumy Regional Clinical Onc Ctr

    Sumy, 40005, Ukraine

  • Sun Yat-sen Memorial Hospital

    Guangzhou, 510000, China

  • Sun Yet-sen University Cancer Center

    Guangzhou, 510060, China

  • Sunshine Hospital

    St Albans, Victoria, 3021, Australia

  • Szpital Morski im. PCK

    Gdynia, 81-519, Poland

  • Tel Aviv Sourasky Medical Ctr

    Tel Aviv, 6423906, Israel

  • Texas Oncology - DFW

    Dallas, Texas, 75246, United States

  • The Cancer Institute Hospital of JFCR

    Tokyo, 135-8550, Japan

  • The Center for Cancer and Blood Disorders - Fort Worth

    Fort Worth, Texas, 76104, United States

  • The Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • The First Affiliated Hospital of Xian Jiao Tong University

    Xi'an, 710061, China

  • The First Hospital of Jilin University

    Changchun, 130021, China

  • Tokai University Hospital

    Kanagawa, 259-1193, Japan

  • Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

    Edirne, 22030, Turkey (Türkiye)

  • Ulsan University Hosiptal

    Ulsan, 44033, South Korea

  • Uniklinikum Salzburg, LKH

    Salzburg, 5020, Austria

  • Universite de Montreal - Hopital Maisonneuve-Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • University College London Hospital

    London, NW1 - 2PG, United Kingdom

  • University of Colorado

    Aurora, Colorado, 80045-2517, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Tsukuba Hospital

    Ibaraki, 305-8576, Japan

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

  • Universitätsklinik Tübingen

    Tübingen, 72076, Germany

  • Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden

    Dresden, 01307, Germany

  • Universitätsklinikum Essen

    Essen, 45122, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitätsklinikum Mannheim

    Mannheim, 68167, Germany

  • Uniwersyteckie Centrum Kliniczne

    Gda?sk, 80-214, Poland

  • Vall d?Hebron Institute of Oncology (VHIO), Barcelona

    Barcelona, 08035, Spain

  • Veterans General Hospital

    Taipei, 00112, Taiwan

  • Virginia Oncology Associates

    Norfolk, Virginia, 23502, United States

  • West Cancer Center

    Germantown, Tennessee, 38138, United States

  • William Osler Health System Brampton Civic Hospital

    Brampton, Ontario, L6R 3J7, Canada

  • Zhejiang Cancer Hospital

    Hangzhou, 310022, China

  • the First Affiliated Hospital of Bengbu Medical College

    Bengbu, 233000, China

Conditions

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