New hope for advanced breast cancer: major trial tests promising drug combo
NCT ID NCT04546009
Summary
This large Phase 3 trial is testing whether a new drug called giredestrant, when combined with palbociclib, works better than the current standard treatment (letrozole + palbociclib) for people with a specific type of advanced breast cancer. The study involves 992 patients whose cancer has spread or returned and is fueled by estrogen but not HER2. The main goal is to see if the new combination can keep the cancer from growing for a longer time while monitoring side effects and quality of life.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ESTROGEN RECEPTOR-POSITIVE, HER2-NEGATIVE, LOCALLY ADVANCED OR METASTATIC BREAST CANCER are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
19 Mayis University Medical Faculty
Samsun, 55139, Turkey (Türkiye)
-
A.Ö. LHK
Steyr, 4400, Austria
-
Affiliated Hospital of Hebei University
Baoding, 071000, China
-
Ambulantes Tumorzentrum Spandau
Berlin, 13581, Germany
-
Ankara Bilkent City Hospital
Ankara, 06490, Turkey (Türkiye)
-
Anticancer Hospital Ag Savas
Athens, 115 22, Greece
-
Anticancer Hospital Ag. Savas
Athens, 115 22, Greece
-
Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde
Morelia, 58260, Mexico
-
Anyang Tumor Hosptial
Anyang, 455000, China
-
Arthur J.E. Child Comprehensive Cancer Center-Calgary
Calgary, Alberta, T2N 5G2, Canada
-
Asan Medical Center
Seoul, 05505, South Korea
-
Asst Di Monza
Monza, Lombardy, 20900, Italy
-
Astera Cancer Care East Brunswick
East Brunswick, New Jersey, 08816, United States
-
Auckland City Hospital
Auckland, 1023, New Zealand
-
Az. Osp. Spedali Civili
Brescia, Lombardy, 25123, Italy
-
Azienda ULSS 8 Berica
Vicenza, Veneto, 36100, Italy
-
BC Cancer ? Surrey
Surrey, British Columbia, V3V 1Z2, Canada
-
Baylor St. Luke's Medical Center
Houston, Texas, 77030, United States
-
Beijing Cancer Hospital
Beijing, 100142, China
-
Beneficencia Portuguesa de Sao Paulo
São Paulo, São Paulo, 01323-900, Brazil
-
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
-
Budapesti Uzsoki Utcai Kórház
Budapest, 1145, Hungary
-
CEMER Centro Medico de Enfermedades Respiratorias
Vicente López, B1602DQD, Argentina
-
Calvary Mater Newcastle
Waratah, New South Wales, 2298, Australia
-
Centre Alexis Vautrin
Vandœuvre-lès-Nancy, 54511, France
-
Centre Eugene Marquis
Rennes, 35042, France
-
Centre Hospitalier de La Cote Basque
Bayonne, 64109, France
-
Centre Hospitalier de l?Université de Montréal (CHUM)
Montreal, Quebec, H2X 3E4, Canada
-
Centro Hospitalar Lisboa Norte
Lisbon, Portugal
-
Centro Oncologico MD Anderson Internacional
Madrid, 28033, Spain
-
Centro de Atencion Oncologica Viva S de RL de CV
Mexico City, Mexico CITY (federal District), 06760, Mexico
-
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, Oaxaca, 68020, Mexico
-
Centro de Investigaciones Médicas y Desarrollo LC S.R.L
Buenos Aires, Ciudad Autónoma de BuenosAires, C1113AAE, Argentina
-
Chaim Sheba Medical Center
Ramat Gan, 52620-00, Israel
-
Chang Gung Memorial Hosipital at Linkou
Taoyuan Hsien, 333, Taiwan
-
Chd de Vendee
La Roche-sur-Yon, 85925, France
-
Chelyabinsk region oncology dispensary
Chelyabinsk, 454087, Russia
-
Chiba Cancer Center
Chiba, 260-8717, Japan
-
China Medical University Hospital
Taichung, 404, Taiwan
-
Chu La Miletrie
Poitiers, 86021, France
-
Chulalongkorn Hospital, Faculty of Medicine
Bangkok, 10330, Thailand
-
Chungbuk National University Hospital
Cheongju-si, 28644, South Korea
-
Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda
São Paulo, São Paulo, 01317-000, Brazil
-
Cliniques Universitaires St-Luc
Brussels, 1200, Belgium
-
Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, 15006, Spain
-
Corporacio Sanitaria Parc Tauli
Sabadell, Barcelona, 8208, Spain
-
Davidof Center - Rabin Medical Center
Petah Tikva, 49100, Israel
-
Derriford Hospital
Plymouth, PL6 8DH, United Kingdom
-
Dres. Andreas Köhler und Roswitha Fuchs
Langen, 63225, Germany
-
Dres. Helmut Forstbauer, Carsten Ziske und Kollegen
Troisdorf, 53840, Germany
-
Dres.Andreas Ammon und Dirk Meyer
Göttingen, 37073, Germany
-
Euromedical General Clinic of Thessaloniki
Thessaloniki, 546450, Greece
-
European Interbalkan Medical Center
Thessaloniki, 570 01, Greece
-
Facharztzentrum Eppendorf, Studien GbR
Hamburg, 20249, Germany
-
Filios Alta Medicina
Monterrey, Nuevo León, 64460, Mexico
-
Fiona Stanley Hospital - Medical Oncology
Murdoch, Western Australia, 6150, Australia
-
Florida Cancer Specialists - Fort Myers (Broadway)
Fort Myers, Florida, 33901, United States
-
Fondazione del Piemonte per l?Oncologia (IRCCS)
Candiolo, Trentino-Alto Adige, 10060, Italy
-
Fujian Medical University Union Hospital
Fujian, 350001, China
-
Fukushima Medical University Hospital
Miyagi, 960-1295, Japan
-
GBUZ Saint Petersburg Clinical Research Center of Specialized Types of Care (Oncology)
Saint Petersburg, Sankt-Peterburg, 197758, Russia
-
Gachon University Gil Medical Center
Incheon, 21565, South Korea
-
Gangnam Severance Hospital
Seoul, 06273, South Korea
-
Guangxi Cancer Hospital of Guangxi Medical University
Nanning, 530021, China
-
Guys & St Thomas Hospital
London, SE1 9RT, United Kingdom
-
HCA Midwest Division
Kansas City, Missouri, 64132, United States
-
HM Sanchinarro ? CIOCC
Madrid, 28050, Spain
-
Hacettepe Uni Medical Faculty Hospital
Ankara, 06100, Turkey (Türkiye)
-
Harbin Medical University Cancer Hospital
Harbin, 150081, China
-
Health Pharma Professional Research
CD Mexico, Mexico CITY (federal District), 03810, Mexico
-
Herlev Hospital
Herlev, 2730, Denmark
-
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, 730-8518, Japan
-
Hiroshima University Hospital
Hiroshima, 734-8551, Japan
-
Honvédelmi Minisztérium Állami Egészségügyi Központ;Onkológiai Osztály
Budapest, 1062, Hungary
-
Hopital du Saint Sacrement
Québec, Quebec, G1S 4L8, Canada
-
Hospital Araujo Jorge
Goiânia, Goiás, 74605-070, Brazil
-
Hospital Britanico
Ciudad Autonoma Bs As, C1280AEB, Argentina
-
Hospital Clinico San Carlos
Madrid, 28040, Spain
-
Hospital Clinico Universitario de Valencia
Valencia, 46010, Spain
-
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
-
Hospital General Universitario Gregorio Marañon
Madrid, 28007, Spain
-
Hospital Provincial del Centenario
Rosario, 2000, Argentina
-
Hospital Quiron de Madrid
Pozuelo de Alarcón, Madrid, 28223, Spain
-
Hospital Ramon y Cajal
Madrid, 28034, Spain
-
Hospital Sao Lucas - PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
-
Hospital Sao Rafael - HSR
Salvador, Estado de Bahia, 41253-190, Brazil
-
Hospital Universitari Dexeus - Grupo Quironsalud
Barcelona, 08028, Spain
-
Hospital Universitario Virgen del Rocio
Seville, 41013, Spain
-
Hospital da Luz
Lisbon, 1500-650, Portugal
-
Hospital de Base de Sao Jose do Rio Preto
São José do Rio Preto, São Paulo, 15090-000, Brazil
-
Hospital de Donostia
Donostia / San Sebastian, Guipuzcoa, 20080, Spain
-
Hospital de Onc Angel Roffo
Buenos Aires, 1425, Argentina
-
Hospital del Mar
Barcelona, 08003, Spain
-
Hospital do Cancer de Pernambuco - HCP
Recife, Pernambuco, 50040-000, Brazil
-
Houston Methodist Hospital
Houston, Texas, 77030, United States
-
Humanitas Centro Catanese Di Oncologia
Misterbianco (CT), Sicily, 95045, Italy
-
Hunan Cancer Hospital
Changsha, 410013, China
-
Hyogo Cancer Center
Hyōgo, 673-0021, Japan
-
ICL
Saint-Priest-en-Jarez, 42271, France
-
ICO Paul Papin
Angers, 49055, France
-
IOV - Istituto Oncologico Veneto - IRCCS
Padua, Veneto, 35128, Italy
-
IPO de Coimbra
Coimbra, 3000-075, Portugal
-
IPO do Porto
Porto, 4200-072, Portugal
-
IRCCS Istituto Regina Elena (IFO)
Rome, Lazio, 00144, Italy
-
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola
Meldola, Emilia-Romagna, 47014, Italy
-
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department
Malatya, 44280, Turkey (Türkiye)
-
Inova Fairfax Hospital
Fairfax, Virginia, 22031, United States
-
Institut Jean Godinot
Reims, 51056, France
-
Institut régional du Cancer Montpellier
Montpellier, 34298, France
-
Instituto Nacional de Enfermedades Neoplasicas
Lima, Lima 34, Peru
-
Instituto Peruano de Oncología y Radioterapia
Lima, Lima 27, Peru
-
Instituto Regional de Enfermedades Neoplasicas - IREN Norte
Trujillo, 13014, Peru
-
Instituto de Oncología de Rosario
Rosario, S2000KZE, Argentina
-
Istituto Europeo Di Oncologia
Milan, Lombardy, 20141, Italy
-
Ivano-Frankivsk Regional Oncology Center
Ivano-Frankivsk, 76018, Ukraine
-
Jessa Zkh (Campus Virga Jesse)
Hasselt, 3500, Belgium
-
Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
-
Kaiser Permanente - Moanalua Medical Center
Honolulu, Hawaii, 96819-1469, United States
-
Kaiser Permanente - San Leandro Medical Center
San Leandro, California, 94577, United States
-
Kaiser Permanente - Walnut Creek
Walnut Creek, California, 94596, United States
-
Kanagawa Cancer Center
Kanagawa, 241-8515, Japan
-
Katip Celebi University Ataturk Training and Research Hospital
Izmir, 35360, Turkey (Türkiye)
-
Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt
München, 80336, Germany
-
Klinikum Chemnitz gGmbH
Chemnitz, 09116, Germany
-
Klinikum Mutterhaus der Borromaeerinnen gGmbH
Trier, 54290, Germany
-
Kocaeli University Faculty of Medicine
İzmit, 31380, Turkey (Türkiye)
-
Korea University Anam Hospital
Seoul, 02841, South Korea
-
Korea University Guro Hospital
Seoul, 8308, South Korea
-
Kumamoto University Hospital
Kumamoto, 860-8556, Japan
-
Kyungpook National University Medical Center
Daegu, 41944, South Korea
-
Leicester Royal Infirmary
Leicester, LE1 5WW, United Kingdom
-
Liaoning cancer Hospital & Institute
Shenyang, 110042, China
-
Long Beach Memorial Medical Center
Long Beach, California, 90806, United States
-
ME Kryviy Rih Oncology Dispensary of Dnipropetrovs?k Regional Council
Kryvyi Rih, 50048, Ukraine
-
MSKCC @ Commack
Commack, New York, 11725, United States
-
MVZ für Hämatologie und Onkologie Ravensburg GmBH
Ravensburg, 88212, Germany
-
Mackay Memorial Hospital
Taipei, 104, Taiwan
-
Maharaj Nakorn Chiang Mai Hosp
Chang Mai, 50200, Thailand
-
Maidstone Hospital
Maidstone, ME16 0FS, United Kingdom
-
Maryland Oncology Hematology
Silver Spring, Maryland, 20902, United States
-
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
-
Mater Hospital Brisbane
South Brisbane, Queensland, 4101, Australia
-
McGill University Health Center
Montreal, Quebec, H4A 3J1, Canada
-
Medipol University Medical Faculty
Istanbul, 34214, Turkey (Türkiye)
-
Medizinische Hochschule Zentrum Frauenheilkunde Abt.Gynäkologische Onkologie
Hanover, 30625, Germany
-
Medizinische Universität Wien
Vienna, 1090, Austria
-
Memorial Regional Cancer Ctr
Hollywood, Florida, 33021, United States
-
Memorial Sloan Kettering Cancer Center Basking Ridge
Basking Ridge, New Jersey, 07920, United States
-
Memorial Sloan Kettering Cancer Center at Bergen
Montvale, New Jersey, 07645, United States
-
Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
-
Mercy Medical Center
Baltimore, Maryland, 21202, United States
-
Multidisciplinary clinic Reaviz
Samara, 443011, Russia
-
Municipal Institution City Clinical Hospital #4 of Dnipro City Council
Dnipropetrovsk, Katerynoslav Governorate, 49102, Ukraine
-
Nagoya University Hospital
Aichi, 466-8560, Japan
-
Naha-nishi Clinic
Okinawa, 901-0154, Japan
-
Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad
Warsaw, 02-781, Poland
-
National Cancer Center
Gyeonggi-do, 10408, South Korea
-
National Cancer Center Hospital
Tokyo, 104-0045, Japan
-
National Cancer Center Hospital East
Chiba, 277-8577, Japan
-
National Cheng Kung Uni Hospital
Tainan, 704, Taiwan
-
National Hospital Organization Hokkaido Cancer Center
Hokkaido, 003-0804, Japan
-
National Hospital Organization Kyushu Cancer Center
Fukuoka, 811-1395, Japan
-
National Hospital Organization Osaka National Hospital
Osaka, 540-0006, Japan
-
National Taiwan Uni Hospital
Taipei, 100, Taiwan
-
Nationales Centrum für Tumorerkrankungen (NCT)
Heidelberg, 69120, Germany
-
Niels-Stensen-Kliniken Franziskus-Hospital Harderberg GmbH
Georgsmarienhütte, 49124, Germany
-
Niigata Cancer Center Hospital
Niigata, 951-8566, Japan
-
Northwest Medical Specialties
Tacoma, Washington, 98405, United States
-
Odense Universitetshospital, Onkologisk Afdeling R
Odense C, 5000, Denmark
-
Oncologico Potosino
San Luis Potosí City, San Luis Potosí, 78209, Mexico
-
Oncosalud Sac
Lima, 41, Peru
-
Orange Coast Memorial Medical Center
Fountain Valley, California, 92708, United States
-
Organización medica de Investi
Cap Fed, 1015, Argentina
-
Osaka International Cancer Institute
Osaka, 541-8567, Japan
-
Ospedale Civile - Livorno
Livorno, Tuscany, 57124, Italy
-
Ospedale Sacro Cuore Don Calabria
Negrar, Veneto, 37024, Italy
-
Ottawa Hospital Research Institute
Ottawa, Ontario, K1Y 4E9, Canada
-
Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong
-
Peter MacCallum Cancer Centre-East Melbourne
Melbourne, Victoria, 3000, Australia
-
Peterborough City Hospital
Peterborough, PE3 9GZ, United Kingdom
-
Podolsk City Clinical Hospital
Podolsk, Moscow Oblast, 142100, Russia
-
Praxis Köppler, Heymann, Weide, Thomalla
Koblenz, 56068, Germany
-
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
-
Princess Margaret Cancer Center
Toronto, Ontario, M5G 2M9, Canada
-
Princess Margaret Hospital
Hong Kong, Hong Kong
-
Providence Portland Medical Ctr
Portland, Oregon, 97213, United States
-
Queen Mary Hospital
Hong Kong, Hong Kong
-
Rajavithi Hospital
Bangkok, 10400, Thailand
-
Ramathibodi Hospital
Bangkok, 10400, Thailand
-
Regional Clinical Oncology Hospital
Yaroslavl, 150040, Russia
-
Respublikanskiy Onkologicheskiy Dispanser
Saransk, Respublika Mordoviya, 430032, Russia
-
Rocky Mountain Cancer Center
Denver, Colorado, 80218, United States
-
Roper St. Francis Healthcare
Charleston, South Carolina, 29414, United States
-
Royal Cornwall Hospital
Truro, TR1 3LQ, United Kingdom
-
Royal Free Hospital
London, NW3 2QS, United Kingdom
-
Royal Marsden Hosp NHS Fnd
Sutton, SM2 5PT, United Kingdom
-
Royal Sussex County Hospital
Brighton, BN2 5BE, United Kingdom
-
Royal Victoria Regional Health Centre
Barrie, Ontario, L4M 6M2, Canada
-
Ryazan Regional clinical oncology dispensary
Ryazan, Ryazan Oblast, 390011, Russia
-
SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
Moskva, Moscow Oblast, 111123, Russia
-
SCRI Florida Cancer Specialists North
St. Petersburg, Florida, 33705, United States
-
SCRI Florida Cancer Specialists PAN
Tallahassee, Florida, 32308, United States
-
SI Institute of general&urgent surgery n/a Zaytseva V.T NAMSU
Kharkiv, Kharkiv Governorate, 61018, Ukraine
-
Sagara Hospital
Kagoshima, 892-0833, Japan
-
Saitama Cancer Center
Saitama, 362-0806, Japan
-
Samsung Medical Center
Seoul, 06351, South Korea
-
San Juan Oncology Associates
Farmington, New Mexico, 87401, United States
-
Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
-
Sarah Cannon Research Institute / Tennessee Oncology
Nashville, Tennessee, 37203, United States
-
Seoul National University Bundang Hospital
Gyeonggi-do, 13620, South Korea
-
Seoul National University Hospital
Seoul, 03080, South Korea
-
Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
-
Shandong Cancer Hospital
Jinan, 250117, China
-
Shengjing Hospital of China Medical University
Shenyang, 110004, China
-
Showa Medical University Hospital
Tokyo, 142-8666, Japan
-
Sir Run Run Shaw Hospital Zhejiang University
Hangzhou, 310016, China
-
Sjællands Universitetshospital, Næstved
Næstved, 4700, Denmark
-
Sociedad de Metabolismo y Corazón (SOMECO)
Veracruz, 91900, Mexico
-
Songklanagarind Hospital
Songkhla, 90110, Thailand
-
St. Elisabeth-Krankenhaus, Senologie/Brustzentrum
Leipzig, 04277, Germany
-
Stanford Univ Medical Center
Stanford, California, 94305, United States
-
Sumy Regional Clinical Onc Ctr
Sumy, 40005, Ukraine
-
Sun Yat-sen Memorial Hospital
Guangzhou, 510000, China
-
Sun Yet-sen University Cancer Center
Guangzhou, 510060, China
-
Sunshine Hospital
St Albans, Victoria, 3021, Australia
-
Szpital Morski im. PCK
Gdynia, 81-519, Poland
-
Tel Aviv Sourasky Medical Ctr
Tel Aviv, 6423906, Israel
-
Texas Oncology - DFW
Dallas, Texas, 75246, United States
-
The Cancer Institute Hospital of JFCR
Tokyo, 135-8550, Japan
-
The Center for Cancer and Blood Disorders - Fort Worth
Fort Worth, Texas, 76104, United States
-
The Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
-
The First Affiliated Hospital of Xian Jiao Tong University
Xi'an, 710061, China
-
The First Hospital of Jilin University
Changchun, 130021, China
-
Tokai University Hospital
Kanagawa, 259-1193, Japan
-
Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi
Edirne, 22030, Turkey (Türkiye)
-
Ulsan University Hosiptal
Ulsan, 44033, South Korea
-
Uniklinikum Salzburg, LKH
Salzburg, 5020, Austria
-
Universite de Montreal - Hopital Maisonneuve-Rosemont
Montreal, Quebec, H1T 2M4, Canada
-
University College London Hospital
London, NW1 - 2PG, United Kingdom
-
University of Colorado
Aurora, Colorado, 80045-2517, United States
-
University of Miami
Miami, Florida, 33136, United States
-
University of Tsukuba Hospital
Ibaraki, 305-8576, Japan
-
University of Wisconsin
Madison, Wisconsin, 53792, United States
-
Universitätsklinik Tübingen
Tübingen, 72076, Germany
-
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
Dresden, 01307, Germany
-
Universitätsklinikum Essen
Essen, 45122, Germany
-
Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246, Germany
-
Universitätsklinikum Mannheim
Mannheim, 68167, Germany
-
Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214, Poland
-
Vall d?Hebron Institute of Oncology (VHIO), Barcelona
Barcelona, 08035, Spain
-
Veterans General Hospital
Taipei, 00112, Taiwan
-
Virginia Oncology Associates
Norfolk, Virginia, 23502, United States
-
West Cancer Center
Germantown, Tennessee, 38138, United States
-
William Osler Health System Brampton Civic Hospital
Brampton, Ontario, L6R 3J7, Canada
-
Zhejiang Cancer Hospital
Hangzhou, 310022, China
-
the First Affiliated Hospital of Bengbu Medical College
Bengbu, 233000, China
Conditions
Explore the condition pages connected to this study.